Baclofen: Uses, Dosage, Price, Side Effects, Precautions & More

Baclofen Composition – Baclofen 10 MG
Manufactured By – La Renon Healthcare Pvt Ltd
Prescription – Prescription Required
Form – Tablet
Price – Rs 100
Quantity – 10 tablets in 1 strip

What is Baclofen?

Baclofen is a type of spasmolytics medication that works by decreasing muscle tone and spasm; a GABAb receptor agonist. It is the best agent for symptomatic treatment of spasticity in ALS. Baclofen can be very helpful in patients that have developed cerebral palsy or some injury to the spinal cord.
Manufactured By – Intas Pharmaceuticals Ltd

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Uses of Baclofen

Baclofen is used to treat:

• Trigeminal neuralgia
• Spasticity
• Cerebral palsy
• Alcoholism
• Dystonia
• Multiple sclerosis

Read other medicine Uses: Januvia Uses

How does Baclofen work?

• Baclofen acts to restore the lost inhibition by stimulating postsynaptic GABA receptors.
• It works by activating the GABAb receptor, which is a metabotropic inhibitory GPCR.
• Baclofen will hyperpolarize neurons and muscle cells by activating potassium channels.

How to take Baclofen?

• Baclofen is taken in the form of tablets.
• It can be taken with food or milk.
• Alternatively, Baclofen can be delivered directly into the space around the spinal cord using a surgically implanted pump and an intrathecal catheter.
• This approach minimizes the adverse effects of Baclofen, especially sedation, but it carries the risk of potentially life-threatening CNS depression.

Baclofen Price In India

Common Dosage for Baclofen

• Initial doses of 5-10 mg per day are recommended.
• It can be increased to as much as 200 mg per day, if necessary.

Also Read: Acetaminophen Dosage | Albuterol Dosage | Amitriptyline Dosage

When to avoid Baclofen?

• Use of Baclofen with other drugs that also depress the function of nerves may lead to an additional reduction in brain function.
• The use of Baclofen and tricyclic antidepressants like amitriptyline (Elavil), doxepin (Sinequan, Adapin) together may cause muscle weakness.
• Use of Baclofen and MOIs like phenelzine (Nardil), tranylcypromine or (Parnate) can cause greater depression as well as low blood pressure.

Precautions when taking Baclofen

• Do not use Baclofen if you are allergic to it or of any of its ingredients. Consult your doctor.
• Let your doctor know about any previous history of kidney disorder, stroke or epilepsy.
• Intrathecal Baclofen should be used only by physicians trained in delivering chronic intrathecal therapy.
• Baclofen increases blood sugar because of which doses of antidiabetic drugs may need to be adjusted.

Side Effects of Baclofen

Abrupt withdrawal of intrathecal Baclofen can cause:

• rebound spasticity,
• rhabdomyolysis,
• multi-organ failure, and
• even death.
• Drowsiness
• Fatigue
• Weakness

Effects on organs

• Cardiovascular- Hypotension. Rare instances of dyspnea, palpitation, chest pain, syncope.
• Neuropsychiatric- Confusion, headache, insomnia and rarely depression, paresthesia, muscle pain, dystonia, ataxia, blurred vision.
• Gastrointestinal- Nausea, constipation and rarely dry mouth, anorexia, abdominal pain, vomiting, diarrhea.
• Skin- rashes, pruritus, ankle edema.

Storage Requirement about Baclofen

• Keep it in a dry place, away from moisture and direct heat.
• Should be kept in a tight container.
• Keep Baclofen out of reach of children.

Pro Tips When Consuming Baclofen

• Do not use Baclofen at a time when muscle tone is needed to assure safe balance and movement for certain activities.
• Using Baclofen may increase your risk of developing an ovarian cyst.
• Withdrawal symptoms such as seizures or hallucinations can occur when you stop using Baclofen after using it over a long period of time.
• Do not stop using Baclofen without consulting your doctor. You may need to use less of it before you stop the medication completely.

FAQs

Is Baclofen addictive?

No, but using Baclofen for a longer time period may cause a few withdrawal symptoms.

Also read about other medicine's: Bupropion | Cialis