List of 19 Best Medicines for Insomnia – Composition, Dosage, Popularity & More (2019)

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List of 19 Best Medicines for Insomnia - Composition, Dosage, Popularity & More (2019)

According to guidelines from a physician group, insomnia is difficulty falling asleep or staying asleep, even when a person has the chance to do so. People with insomnia can feel dissatisfied with their sleep and usually experience one or more of the following symptoms: fatigue, low energy, difficulty concentrating, mood disturbances, and decreased performance in work or at school.

Insomnia is a common sleep problem for adults. The National Institutes of Health estimates that roughly 30 percent of the general population complains of sleep disruption, and approximately 10 percent have associated symptoms of daytime functional.

Insomnia may be characterized based on its duration. Acute insomnia is brief and often happens because of life circumstances (for example, when you can’t fall asleep the night before an exam, or after receiving stressful or bad news). Many people may have experienced this type of passing sleep disruption, and it tends to resolve without any treatment.

Chronic insomnia is disrupted sleep that occurs at least three nights per week and lasts at least three months. Chronic insomnia disorders can have many causes. Changes in the environment, unhealthy sleep habits, shift work, other clinical disorders, and certain medications could lead to a long-term pattern of insufficient sleep. People with chronic insomnia may benefit from some form of treatment to help them get back to healthy sleep patterns. Chronic insomnia can be comorbid, meaning it is linked to another medical or psychiatric issue, although sometimes it’s difficult to understand this cause and effect relationship.

People with insomnia tend to have difficulty falling asleep (onset), staying asleep (maintenance), and/or they wake up too early in the morning. Treatment for insomnia can include behavioral, psychological, medical components or some combination thereof. You and your doctor will need to talk about your particular situation and history of insomnia, as well as its causes, to decide on the best treatment plan.

The most common agent in over-the-counter sleeping aids is diphenhydramine, an antihistamine. It usually has a relaxing effect that makes you feel drowsy, but it may cause some grogginess the next day. Some popular OTC sleep aids also include pain relievers, which you may not need to take for insomnia or sleep problems.

Although over-the-counter sleep medications are available without a prescription and are generally considered safe, you should check with the pharmacist about any potential side effects or adverse drug interactions with other drugs you are taking for other health conditions like high blood pressure.

You should be careful to take them only as directed especially if you’re taking other drugs that also contain antihistamines, like cold or allergy medications. Also, antihistamines can cause confusion in the elderly.

“The over-the-counter stuff can work in a pinch, but it’s generally not good for long-term use,” says Tracey Marks, MD, a psychiatrist in Atlanta and author of Master Your Sleep.

If you’re having a sleep problem that lasts a few days, talk to your doctor about your concerns. You may have an underlying health problem, like a sleep disorder or depression.

Depending on the cause of your sleeping problem, he or she may prescribe a sleep medication, which is the most common treatment for insomnia.


List of Top 19 Medicines for Insomnia

  1. Trazodone
  2. Doxepine
  3. Eszopiclone
  4. Ramelteon
  5. Suvorexant
  6. Zaleplon
  7. Zolpidem
  8. Eszopiclone
  9. Zopiclone
  10. Ramelteon
  11. Modafinil
  12. Methylphenidate
  13. Sodium Oxybate
  14. Flurazepam
  15. Diazepam
  16. Nitrazepam
  17. Alprazolam
  18. Clonazepam
  19. Lorazepam

Top 19 Medicines for Insomnia in India (Tablets, Syrups & More)

In some cases, doctors will prescribe drugs for the treatment of insomnia. All insomnia medications should be taken shortly before bed. Do not attempt to drive or perform other activities that require concentration after taking an insomnia drug because it will make you sleepy. Medications should be used in combination with good sleep practices.

1. Trazodone: Cures insomnia and anxiety

  • Brand name – Desyrel
  • CompositionTrazodone
  • Popularity level – 4
  • Trazodone is an antidepressant drug,  thus it calms/relaxes the brain. It is used for treating insomnia and anxiety.
  • Benzodiazepines –  These older sleeping pills — temazepam (Restoril), triazolam (Halcion), and others — may be useful when you want an insomnia medication that stays in the system longer. For instance, they have been effectively used to treat sleep problems such as sleepwalking and night terrors. But these drugs may cause you to feel sleepy during the day and can also cause dependence, meaning you may always need to be on the drug to be able to sleep.
  • Price – The cost for trazodone oral tablet 50 mg is around $10 for a supply of 7 tablets.

2. Doxepine: Cures insomnia associated with frequent nocturnal awakening

  • Brand name – Silenor
  • Composition – Doxepine
  • Popularity level – 6
  • This sleep drug is approved for use in people who have trouble staying asleep. Silenor may help with sleep maintenance by blocking histamine receptors.
  • Do not take this drug unless you are able to get a full 7 or 8 hours of sleep.
  • Price – The price range for Silenor 3 mg is $1.43 – $2.3 per pill or unit.

3. Eszopiclone: Cures sleep onset insomnia

  • Brand name – Lunesta
  • Popularity level – 6.5
  • Lunesta helps you fall asleep quickly, and studies show people sleep an average of 7 to 8 hours.
  • Don’t take Lunesta unless you are able to get a full night’s sleep as it could cause grogginess.
  • Dosage – Because of the risk of impairment the next day, the FDA recommends the starting dose of Lunesta is no more than 1 milligram.
  • Price – The cost for Lunesta oral tablet 1 mg is around $500 for a supply of 30 tablets.

4. Ramelteon: Cures sleep onset insomnia

  • Brand name – Rozerem
  • Composition – Ramelteon
  • Popularity level – 7
  • This sleep medication works differently than the others. It works by targeting the sleep-wake cycle, not by depressing the central nervous system. It is prescribed for people who have trouble falling asleep.
  • Rozerem can be prescribed for long-term use, and the drug has shown no evidence of abuse or dependence.
  • Price – A pack of 30 ramelteon 8-mg tablets costs approximately $82.

6. Suvorexant: Cures insomnia

  • Brand name – Belsomra
  • Composition – Suvorexant
  • Popularity level – 5
  • This drug acts as an orexin receptor inhibitor involved in regulating sleep and wake cycles.  It is approved by the FDA to treat people that have insomnia due to an inability to fall asleep or to stay asleep. The drug may cause you to feel sleepy the following day.
  • Price – Belsomra can cost around $380 for a supply of 30, 5 mg tablets.

7. Zaleplon: Cures sleep onset insomnia

  • Brand name – Sonata
  • Composition – Zaleplon
  • Popularity level – 7.5
  • Zaleplon is a non-benzodiazepine hypnotic drug. It is used for inducing sleep,  it doesn’t prolong the sleeping duration.
  • Of all the newer sleeping pills, Sonata stays active in the body for the shortest amount of time. That means you can try to fall asleep on your own.
  • Price – Sonata 1.5g sachet costs ₹35.

8. Zolpidem: Cures short-term insomnia

  • Brand name – Ambien, Edluar, Intermezzo
  • CompositionZolpidem
  • Popularity level – 6
  • These medicines work well at helping you get to sleep, but some people tend to wake up in the middle of the night. Zolpidem is now available in an extended release version, Ambien CR. This may help you go to sleep and stay asleep longer.
  • Dosage – 5-10 mg at bedtime.
  • The FDA warns that you should not drive or do anything that requires you to be alert the day after taking Ambien CR because it stays in the body for a long time. You should not take zolpidem unless you are able to get a full night’s sleep — at least 7 to 8 hours. The FDA has approved a prescription oral spray called Zolpimist, which contains zolpidem, for the short-term treatment of insomnia brought on by trouble falling asleep.
  • Price – The cost for Ambien oral tablet 5 mg is around $1,766 for a supply of 100 tablets.

9. Eszopiclone: Cures insomnia

  • Brand name – Lunesta
  • Composition – Eszopiclone
  • Popularity level – 6
  • It is a non-benzodiazepine hypnotic drug that is used for treating sleep onset insomnia.
  • Price – The cost for eszopiclone oral tablet 1 mg is around $94 for a supply of 100 tablets.

10. Zopiclone: Cures short-term insomnia

  • Brand name – Zopitran, Zopicom, Zolicum
  • Composition – Zopiclone 7.5 mg
  • Popularity level – 5
  • This drug acts as an agonist at a subtype of BZD receptor involved in hypnotic action. It may cause some day time sedation.
  • Zopiclone has been used to wean off insomniacs taking regular benzodiazepine medication.
  • This medicine should only be used for a short period of time.
  • Dosage –  One tablet at night for not more than 2-4 weeks.
  • Price – A pack of 10 tablets cost ₹45.

11. Ramelteon: Cures short-term insomnia

  • Brand name – Rozerem
  • Composition – Ramelteon
  • Popularity level – 7
  • This drug acts as an agonist at a subtype of BZD receptor involved in hypnotic action but it doesn’t cause day time sedation.
  • This medicine should only be used for a short period of time.
  • Dosage –  One tablet at night for not more than 2-4 weeks.
  • Price – A pack of 30 ramelteon 8-mg tablets costs approximately $82.

12. Modafinil 

  • Brand name – Provigil
  • Composition – Modafinil bromide
  • Popularity level – 6
  • Modafinil is an anti-narcoleptic drug
  • Price – The cost for Provigil oral tablet 100 mg is around $1,071 for a supply of 30 tablets.

13. Methylphenidate 

  • Brand name – Ritalin
  • CompositionMethylphenidate
  • Popularity level – 4
  • Methylphenidate is an anti-narcoleptic drug
  • Price – The cost for Ritalin oral tablet 5 mg is around $77 for a supply of 100 tablets.

14. Sodium Oxybate

  • Brand name – Xyrem
  • Composition – Sodium Oxybate
  • Popularity level – 4
  • Sodium Oxybate is an anti-narcoleptic drug
  • The cost for Xyrem oral liquid (500 mg/mL) is around $4,514 for a supply of 180 milliliters.

15. Flurazepam: Cures insomnia associated with frequent nocturnal awakening

  • Brand name – Nindral, Fluraz
  • Composition – Flurazepam
  • Popularity level – 6
  • Flurazepam is a benzodiazepine drug, which works by acting on the BZD receptor. This drug stays in the body for a long duration of time.  It is suitable for people who have a frequent nocturnal awakening and in whom some day time sedation is acceptable.
  • Dosage –  15mg at bedtime.
  • Price – A pack of 10 tablets of Nindral cost ₹13.

16. Diazepam: Cures insomnia and anxiety

  • Brand name – Valium, Calmpose
  • Composition – Diazepam
  • Popularity level – 5
  • It is the oldest BZD drug used to treat insomnia and anxiety. It stays in the body for a long duration of time but causes minimal side effects.
  • Dosage –  As prescribed by the doctor. The dose may vary between 2.5 to 10mg per day.
  • Price – A pack of 60 tablets of valium cost $20.

 17. Nitrazepam: Cures insomnia associated with   frequent nocturnal awakening

  • Brand name – Sedamin, Hypnotex, Nitravet
  • Composition – Nitrazepam
  • Popularity level – 3
  • This drug is equipotent to diazepam and works by the same mechanism. It is good for patients with frequent nocturnal awakening when some daytime sedation is acceptable.
  • Price – A pack of 10 tablets of Nitravet costs ₹50.

18. Alprazolam: Cures chronic insomnia

  • Brand name – Alprax 0.25mg
  • Composition – Alprazolam
  • Popularity level – 7
  • This is a benzodiazepine drug, which works by acting on the BZD receptor. This drug is very potent and may cause daytime sedation.
  • Discontinuation after regular use produces relatively marked withdrawal symptoms.
  • Price – A pack of 15 tablets cost ₹21.

19. Clonazepam: Cure’s parasomnia and short-term insomnia

  • Brand name – Klonopin
  • Composition – Clonazepam
  • Popularity level – 8
  • This hypnotic drug directly acts on the BZD receptor. It is generally used for treating parasomnia and short term insomnia. The drug is likely to cause day time sedation.
  • Price – The cost for Klonopin oral tablet 0.5 mg is around $275 for a supply of 100 tablets

20. Lorazepam: Cure’s parasomnia and short-term insomnia

  • Brand name –  Ativan
  • Composition – Lorazepam
  • Popularity level – 6
  • This drug also acts directly on the BZD receptor and used for treating parasomnia and short term insomnia but is less likely to cause prolonged day time sedation.
  • Price – A pack of 10 tablets cost ₹40.

 

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