List of 18 Best Medicines for Migraine – Composition, Dosage, Popularity & More (2019)

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List of 18 Best Medicines for Migraine - Composition, Dosage, Popularity & More (2019)

A migraine is not the same as the usual kind of headaches that most people have every now and then. A migraine attack starts suddenly with severe pain on only one side of your head. The pain is much worse than a normal headache and usually accompanied by other symptoms as well. But these headaches are only considered to be migraines if the typical symptoms have occurred at least five times.

Migraines can greatly affect everyday life. Some people only get them occasionally, while others are knocked out by migraines on several days every month. Different types of medicine can help you cope with migraines.

Migraines are more common in women than in men. About 14 out of 100 women and 7 out of 100 men have recurring migraines. This is different for children, where migraines are equally common in boys and girls: About 4 to 5 out of 100 children are affected.

More than 10 million cases per year (India).

Symptoms – Migraines are typically associated with moderate to severe headaches that only affect one side of the head. People usually describe the pain as pulsating, throbbing or pounding. It often gets worse during physical activity or even if you move a little. The headaches may be accompanied by nausea or vomiting. When children have migraines, they may not have a headache – instead, the main symptoms might be nausea, vomiting or dizziness.

Some people also become very sensitive to light or noise during migraine attacks. Left untreated, the symptoms last between four hours and three days.

Before an actual migraine becomes noticeable, some people see flashing lights or strange shapes. Others might see everything as a blur or through wavy lines. People may temporarily have trouble speaking, experience paralysis in some parts of their body or have abnormal sensations such as tingling. Doctors call these kinds of disturbances “auras.” They usually go away within an hour and are then followed by more typical migraine symptoms.

Causes – It’s not clear exactly what causes migraines. According to one theory, it has something to do with inflamed blood vessels in the brain. The way in which the brain processes pain signals may play a role too. Stress is often an important factor when it comes to pain: Feeling nervous or tense can make the pain worse or more likely to arise in the first place. So hectic days without enough breaks may increase the risk of getting a migraine. Migraines may also start once the stress has subsided – for instance, on the weekend or during the first few days of vacation. An irregular eating and sleeping schedule can increase the likelihood of migraine attacks too.

The two main categories of acute migraine treatments you can administer yourself are:

1) Over the Counter – Milder migraines can be treated with non-steroidal anti-inflammatories, like ibuprofen or naproxen. Aspirin is a popular over-the-counter choice, either alone or with caffeine and acetaminophen in the form of Excedrin Migraine.

2 ) Prescription Meds – One class of prescription drugs, called triptans, are formulated to specifically abort a migraine attack. There are several different kinds of triptans like Imitrex, as well as different delivery methods for the drug, so you have many options of relief no matter the situation. A few other types of medications, such as ergotamines, can be self-administered as rescue medications if you don’t respond to triptans. Triptans and ergotamines are contraindicated for those with heart disease.


 List of Top 18 Medicines for a Migraine

  1. Ergotamine
  2. Dihydroergotamine
  3. Sumatriptan
  4. Rizatriptan
  5. Frovatriptan
  6. Metoclopramide
  7. Diphenhydramine
  8. Domeperidone
  9. Propanolol
  10. Amitriptyline
  11. Flunarizine
  12. Valproic acid
  13. Gabapentin
  14. Topiramate
  15. Paracetamol
  16. Aspirin
  17. Ibuprofen
  18. Naproxen

Top 18 Medicines for a Migraine in India (Tablets, Syrups, Ointment & More)

1. Ergotamine: Cures a migraine

  • Brand name – Migril
  • Composition – Ergotamine 2 mg, caffeine 100mg and cyclizine 50mg
  • Popularity level – 5
  • Ergotamine acts by constricting the dilated cranial vessels. Given early in the attack, relief is often dramatic and lower doses suffice,  but when the pain has become severe — larger doses are needed.
  • Dosage – Oral/sublingual route is preferred,  1mg is given at half-hour internals till relief is obtained or a total of 6mg is given.
  • Price – A pack of 10 tablets of Migril cost around ₹14.

2. Dihydroergotamine: Cures severe migraine attack

  • Brand name – Migranal (Nasal drop), Dihydroergotamine injection
  • Composition – Dihydroergotamine Mesylate
  • Popularity level – 6
  • Dihydroergotamine is as effective as ergotamine and preferred for parental administration. It can also be used in the form of nasal drops.
  • Price – The cost for Migranal nasal spray (4 mg/mL) is around $3,845 for supply of 8 milliliters.

3. Sumatriptan: Cures a migraine and associated nausea and vomiting

  • Brand name – Migratan, Suminat, Sumitrex
  • Composition –  Sumatriptan
  • Popularity level – 7
  • Sumatriptan causes 5HT-1D receptor-mediated constriction of dilated cranial blood vessels. Dilatation of these shunt vessels during migraine attack is believed to divert blood flow away from brain parenchyma. This drug has fewer side effects than ergotamine. It also suppresses nausea and vomiting due to a migraine.
  • Dosage –  25 – 100mg depending on the severity of migraine attack.
  • Price – A single tablet pack of sumitrex costs ₹20.

4. Rizatriptan: Cures a migraine and associated nausea and vomiting

  • Brand name – Rizact, Rizatan
  • Composition – Rizatriptan
  • Popularity level – 8
  • It is a congener of sumatriptan and has higher oral availability with a slightly faster onset of action.
  • Dosage –  5-10mg, repeat once after 2 hr (if required).
  • Price – A pack of 4 tablets of rizact cost ₹250.

5. Frovatriptan: Curesa migraine, nausea, and vomiting

  • Brand name – Frova
  • Composition – Frovatriptan
  • Popularity level – 5
  • This drug acts by dilating cranial blood vessels by acting on 5HT-1B receptors. It has a very long duration of effect, thus can control  recurrence of a headache after a migraine attack.
  • Dosage – 2.5 – 5 mg initially; max dose is 7.5 mg.
  • Price – The cost for Frova oral tablet 2.5 mg is around $769 for a supply of 9 tablets.

6. Metoclopramide: Relieves nausea, vomiting and gastric stasis

  • Brand name – Metoclop
  • CompositionMetoclopramide
  • Popularity level – 4
  • This is an antiemetic drug that doesn’t cure a migraine, but relieves nausea, vomiting and gastric stasis associated with it.
  • Dosage – 10mg orally or by i.m injection
  • Price – A pack of 10 tablets costs ₹8.

7. Diphenhydramine: Relieves vomiting and calms the mind

  • Brand name – Zendryl 25mg
  • CompositionDiphenhydramine
  • Popularity level – 5
  • It is an antiemetic and sedative drug,  thus it prevents the occurrence of vomiting and causes sedation.
  • Dosage –  10-20 mg orally
  • Price – A pack of 10 capsules cost ₹30.

8. Domeperidone: Relieves vomiting

  • Brand name – Domep 10mg
  • Composition – Domeperidone
  • Popularity level – 7
  • Domeperidone being an antiemetic drug, prevents vomiting associated with a migraine.
  • Dosage – 20mg orally
  • Price – A pack of 10 capsules cost ₹55.

9. Propanolol: Reduces frequency and severity of migraine attacks

  • Brand name – Propanal 40mg
  • Composition – Propanolol
  • Popularity level – 8
  • Propanolol acts as a β adrenergic blocker. This drug is used for prophylaxis of a migraine in patients who tend to get 2-3 attacks per month.
  • Dosage –  The starting dose is 40mg twice a day,  which may be increased upto 160 mg twice a day if required.
  • Price – A pack of 10 capsules cost ₹36.

10. Amitriptyline: Reduces frequency of migraine attacks

  • Brand name – Amitriptyline 10mg
  • CompositionAmitriptyline
  • Popularity level – 3
  • This is an antidepressant drug which also helps in reducing migraine attacks due it’s 5-HT receptor blocking property.  This drug is most suitable for patients who suffer from depression as well as a migraine.
  • Dosage – 25-50mg at bedtime
  • Price – A pack of 10 tablets cost ₹20.

11. Flunarizine: Reduces frequency of migraine attacks

  • Brand name – Nomigrain, Flunarin
  • CompositionFlunarizine
  • Popularity level – 6
  • Flunarizine is a calcium channel blocker, which benefit a migraine by reducing intracellular calcium overload due to brain hypoxia and other causes.
  • Dosage – 10-20mg once in a day
  • Price – Flunarin 10 mg is supplied in a strip of 10 tablets which cost ₹45.

12. Valproic acid: Prevents migraine attacks

  • Brand name – Epsoval 500mg
  • Composition – Valproic acid
  • Popularity level – 3
  • This is an anticonvulsant drug which also helps to reduce the frequency of migraine attacks. It is indicated in patients refractory to other drugs or when propanolol is contraindicated.
  • Dosage – 400-1200mg per day
  • Price – A pack of 6 tablets cost ₹52.

13. Gabapentin: Prevents migraine attacks

  • Brand name – Gabapin 100 mg
  • Composition – Gabapentin
  • Popularity level – 3
  • This is also an anticonvulsant drug which also helps to reduce the frequency of migraine attacks. It is indicated in patients refractory to other drugs or when propanolol is contraindicated.
  • Dosage – 300-1200mg per day
  • Price – A pack of 10 tablets costs ₹100.

14. Topiramate: Prevents migraine attacks

  • Brand name – Topaz 50mg
  • Composition – Topiramate
  • Popularity level – 4
  • This is a newly found anticonvulsant drug which has been approved for prophylaxis of a migraine. It has been shown to reduce the frequency of attacks up-to 50%.
  • Dosage – Start with 25mg once in a day and gradually increase to 50mg once or twice in a day.
  • Price – A pack of 15 tablets costs ₹130.

15. Paracetamol: Cures a mild migraine

  • Brand name – Dolo 650
  • Composition – Paracetamol
  • Popularity level – 8
  • Paracetamol acts as an analgesic drug. If taken at the first indication of an attack, it suppresses most mild attacks.
  • Dosage – 0.5 to 1mg dose should be repeated every 4-6 hours as per requirement.
  • Price – A pack of 15 tablets cost ₹60.

16. Aspirin: Cures mild migraine attacks

  • Brand name – Aspirin200mg
  • CompositionAspirin
  • Popularity level – 8
  • Aspirin also acts as an analgesic drug. If taken at the first indication of an attack, it suppresses most mild attacks.
  • Dosage – 300-600mg dose should be repeated every 4-6 hours as per requirement.
  • Price – A pack of 10 tablets costs ₹2.

17. Ibuprofen: Cures mild migraine attacks

  • Brand name – Brufen 400 mg
  • CompositionIbuprofen
  • Popularity level – 8
  • Ibuprofen is a non steroidal anti inflammatory drug. It is more effective in a migraine without aura. Long term treatment with this drug is not recommended.
  • Dosage – 400-800mg, 8 hourly as per need.
  • Price – A pack of 15 tablets cost ₹10.

18. Naproxen: Cures mild migraine attacks

  • Brand name – Naprosyn 500mg
  • Composition – Naproxen
  • Popularity level – 7
  • This is a non steroidal anti inflammatory drug which helps to reduce the frequency of attacks and also reduces the severity of attack if taken in the earlier stage.
  • Dosage – 500mg followed by 250 mg, 8 hourly as per need.
  • Price – A pack of 15 tablets cost ₹50.

 

 

 

 

 

 

 

 

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