What is Captopril?

  • Captopril is potent and an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension and some types of congestive heart failure.
  • It is used to treat heart failure, protect the kidneys from harm due to diabetes, and to improve survival after a heart attack.
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Uses of Captopril

Captopril is prescribed for:

  • Hypertension
  • Congestive heart failure
  • Preservation of kidney function in diabetic nephropathy
Read About: Cetaphil Uses

How does Captopril work?

  • Captopril antagonizes the effect of the RAAS, which is a homeostatic mechanism for regulating hemodynamics, water and electrolyte balance.
  • It works by preventing the conversion of angiotensin I to angiotensin II, thus inhibiting production of the angiotensin converting enzyme.

How to take Captopril?

  • Captopril is administered orally in the form of tablet.
  • This medication is taken on an empty stomach (at least 1 hour before meals), usually two to three times a day.

Common dosage of Captopril

  • Adult dose for hypertension is 25 mg orally, 2 to 3 times a day.
  • Maintenance dose is 50 mg orally three times a day which may be increased every 1 or 2 weeks. Maximum dose is 450 mg per day.
  • Adult dose for congestive heart failure is 25 mg orally three times a day.
  • Dose for left ventricular dysfunction is 6.25 mg orally once as early as three days post-myocardial infarction, followed by 12.5 mg orally three times a day. This can be increased to 25 mg orally three times a day over the next several days.
  • Dose for diabetic nephropathy is 25 mg orally three times a day.

When to avoid Captopril & Precautions to take?

  • Avoid using Captopril if you are allergic to it or any other inactive ingredients present along with it.
  • Captopril is not recommended for use in combination with aliskiren due to the increased risk of serious side effects which is especially higher in diabetic patients.
  • This drug may cause hypotension, especially when used in combination with other high blood pressure medicines.
  • Captopril may significantly increase the potassium levels in the blood which cause serious adverse effects.
  • Captopril may also cause the presence of excess proteins in urine (proteinuria) which may be a sign of severe kidney problems.
  • Captopril medicine is not recommended for use in pediatric patients.
  • Caution is advised in patients with bone marrow suppression, liver disease, and renal dysfunction.
  • It is advised to avoid a high potassium diet during treatment with this medicine due to the increased risk of serious adverse effects.
Also Read: Canesten Precaution

Side Effects of Captopril

  • Cough
  • Itching
  • Headache
  • Tachycardia
  • Chest pain
  • Palpitations
  • Weakness

Effect on organs?

  • Dermatologic reactions- Rash, pruritus, alopecia.
  • Gastrointestinal reactions- Nausea, vomiting, abdominal pain, dry mouth, diarrhea, constipation, gastric irritation.
  • Nervous system reactions- Dizziness, taste impairment, loss of taste.
  • Respiratory reactions- Cough, dyspnea.
  • Cardiovascular reactions- Hypotension.
  • Genitourinary reactions- Proteinuria.
  • Psychiatric reactions- Sleep disorder, loss of libido.

Reported allergic reactions?

Allergic reactions may include:

  • Hives
  • Rash
  • Itching
  • Wheezing
  • Trouble breathing
  • Swelling of face, throat, hands/legs

Drug interactions to be careful about?

  • Allopurinol
  • Aliskiren
  • Insulin
  • Diclofenac
  • Candesartan
  • Sacubitril/Valsartan

Shows effects

The effect of this medicine can be observed within 15-60 minutes of administration of it and lasts for up to 8 to 12 hours.

Storage Requirements for Captopril

  • Keep it in an air-tight container.
  • Keep it away from direct light or moisture.
  • Keep it out of reach of children.

Pro Tips when taking Captopril

Patients are advised to follow a strict exercise and diet regimen along with captopril to get the best possible effect.


Is Captopril addictive?


Can I have Captopril with alcohol?


Any particular food item to be avoided?

Avoid potassium-rich food.

Can I have Captopril when pregnant?


Can I have Captopril when feeding a baby?


Can I drive after taking Captopril?

Yes; only if not feeling dizzy after taking the medicine.

What happens if I overdose on Captopril?

Overdose of Captopril may cause drowsiness, hypotension or even suicide.

What happens if I eat expired Captopril?

Expired captopril drug may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use expired drug.

What happens if I miss a dose of Captopril?

If you miss a dose of Captopril drug, skip it and continue with your normal schedule. Do not double dose for a missed one.

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