Table of Contents
- What is Combiflam?
- Uses of Combiflam
- How Does Combiflam Work?
- How to Take Combiflam?
- Common Dosage for Combiflam
- When to Avoid Combiflam?
- Precautions While Taking Combiflam
- Side-Effects of Combiflam
- Drug Interactions With Combiflam to be Careful About
- Combiflam Composition, Variant and Price – Buyer’s Guide
- Substitutes of Combiflam
- FAQs – 10 Important Questions Answered about Combiflam
- Authored By –
1What is Combiflam?
Combiflam is a combination of Ibuprofen and Paracetamol. It is one of the most widely used drugs in India. It is used predominantly for relief from pain as it is an analgesic, and fever, as it has antipyretic properties as well. Its major side effect is liver damage, which happens on repetitive usage at high doses. Combiflam should be avoided by anyone who might have a gastric ulcer or any liver disease.
Combiflam Composition – Ibuprofen 400mg, Paracetamol 325mg
Manufactured By – Sanofi India Limited
Prescription – Required (belongs to schedule ‘H’) but it is also available as OTC
Form – Tablets
Price – 28.63 (20 tablets)
Expiry/Shelf Life – 24 months from the date of manufacturing
Type of Drug –Analgesic, and Antipyretic
2Uses of Combiflam
Combiflam serves a dual purpose as it works for pain as well as fever. It is prescribed for the following:
- Fever: It is used for fever as it has got paracetamol which is anti-pyretic in nature.
- Headache: Used as a pain reliever as it has Ibugesic (NSAIDs).
- Muscular Pain: Used to treat muscular pain and tender joints in case of osteoarthritis & gout.
- Menstrual Cramps: Used to treat abdominal cramps during the menstrual cycle in women.
- Toothache: Used to treat mild to moderate pain in teeth.
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3How Does Combiflam Work?
- Combiflam works by inhibiting the Cyclo-oxygenase (COX) enzymes which further inhibits the production of Prostaglandins which are the reason behind the initiation of pain
- Prostaglandins are the reason for causing pain, swelling, and redness at the site of injury
- Therefore, when production of COX enzymes is inhibited; prostaglandin production is also hindered which in turn eases the pain, and increases the blood flow across the skin, heat loss and sweating
- Ibuprofen and paracetamol inhibit COX enzymes and leads to pain cessation
4How to Take Combiflam?
- Combiflam is usually available in tablet and suspension forms.
- Tablets are usually administered orally (Via mouth) with a glass of water as instructed by the doctor. It should be taken with food or after food, and not with an empty stomach as the acidic contents of the empty stomach may affect the pharmacological activity of the tablet and can even affect the stomach.
- The tablet should never be crushed or chewed.
- Before consuming suspension form of Combiflam, it should be shaken up properly to have a homogenous mix of medication and a measuring cup should be used always for correct dose administration.
- It is recommended for a patient to go through the leaflet inside the package thoroughly to have a better understanding of the drug.
5Common Dosage for Combiflam
- The dosage of the drug is to be decided by the doctor for every individual as per the age, weight, mental status, allergic history of the patient.
- The common dose of Combiflam is decided as per the severity of the pain and at least a gap of 4-6 hours should be there between the two doses.
Q. What happens if I overdose on Combiflam?
The doctor should be consulted immediately in case of Combiflam overdose, as gastric emptying (gastric lavage) is to be performed as a treatment measure.
Q. What happens if I miss a dose of Combiflam?
The drug may not exhibit proper effects, if you miss a dose because, for effective working of the drug, a certain amount of drug must be present in your body at all times.
Consume the missed dose always as soon as you remember it. But, do not take a double dose if it’s already time to take the second dose after that as it may lead to an overdose of the drug.
Q. What happens if I eat expired Combiflam?
An adverse event is very unlikely to occur by a single dose of an expired drug. However, the physician should be consulted if one feels unwell or sick after consuming an expired medicine. An expired drug might not be as potent in treating the condition. But it is advisable to refrain from using an expired drug.
Q. What is the onset time of Combiflam?
Combiflam Tablets reaches its peak effect or shows the result in about 30-45 minutes after oral administration.
Q. Till When Does The Effect of Combiflam Stay?
The effect of Combiflam stays for 5 to 6 hours.
6When to Avoid Combiflam?
Do not Consume Combiflam Tablets in the following scenarios:
- Allergy: In known cases of Combiflam (Paracetamol, Ibuprofen) or Other NSAIDs (Aspirin, Diclofenac) induced an allergic reaction.
- Asthma: In known cases of Combiflam or other NSAIDs induced asthma attack, irritation, and swelling of nose and face or current condition of Asthma.
- Gastric Problems: In known cases or history of stomach or intestinal ulcer, Combiflam may lead to bleeding of the stomach.
- Liver Diseases: In cases of past or current condition of Liver problems.
- Kidney Diseases: In cases of past or current condition kidney diseases.
- Heart Diseases: In cases of current condition or history of Heart diseases like Heart failure or Stroke.
- Blood Disorders: In cases of blood disorders like Porphyria and also in cases where the patient is more prone to bleed.
7Precautions While Taking Combiflam
- Empty Stomach: Do not take Combiflam empty stomach as it can lead to decreased efficacy of the drug as well as stomach upset.
- Allergic Reaction: Any allergic reaction should be immediately reported to the doctor.
- Avoid Overdosage: An overdose of the drug should be avoided.
- Time Interval: A gap of 4-6 hours should be maintained between the two doses to avoid increased levels of the drug in the blood as it can lead to toxicity.
Warnings When Taking Combiflam
- Consuming more than the daily prescribed dose may lead to liver damage and serious allergic reactions like swelling of face, lips, and throat.
- Bronchospasm may be precipitated in patients with a history or presently suffering from bronchial asthma.
- Patients in whom Aspirin or other NSAIDs induce symptoms of asthma, rhinitis or urticaria should not be administered Combiflam or any other drug containing Ibuprofen
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8Side-Effects of Combiflam
The side effects associated with Combiflam Tablets used for different treatments are:
- Heartburn – common
- Vertigo – common
- Red itchy rashes on the skin – rare
- Liver toxicity – rare but major side effect due to a repetitive overdose of drug
- Dizziness – less common
- Nausea – common
- Discomfort in the upper abdomen – less common
- Indigestion – less common
- Insomnia – less common
- Diarrhoea – common
- Abdominal pain – less common
- Gastritis (if taken empty stomach frequently)
- Vomiting – less common
- Ulcers in the mouth – less common
- Constipation – common
- Decreased urine output – rare
- Yellowing of eyes/skin – less common
Are There Any Reported Allergic Reactions to Combiflam?
Possible allergic reactions reported for Combiflam tablets are:
- Excessive pain – less common
- Wheezing – common
- Difficulty in breathing – less common
- Vomiting – common
- Rashes and itching on the skin (rare): rashes and itching on the skin are rare but can occur due to an allergy with Combiflam
- Painful, tender wounds on lips and mouth – rare
What Are The Effects of Combiflam Tablets on Organs?
- The dose of Combiflam should be reduced in patients suffering from liver diseases as a high dose of paracetamol can increase the chances of further damage to the liver.
- The doctor should be consulted before taking Combiflam Tablets if one is suffering from kidney disease as suitable dose adjustment and monitoring of kidney functions is mandatory in such cases.
9Drug Interactions With Combiflam to be Careful About
One needs to be careful of certain drug interactions when consuming Combiflam. These may span from certain food items to other medicines to some tests which should not be taken right after consuming Combiflam. We explore these n details below.
1. Food Interactions with Combiflam
No particular food item to be avoided apart from alcohol as it may cause liver damage
2. Medicines Interactions with Combiflam
All the possible drug interactions might not be listed here. It is always advised that the patient must inform the physician about of all the drugs/products you use. You must also inform about the herbal products that you are consuming. You must not modify the drug regimen without your doctor’s approval.
The following drug interactions have their own effects and results, that can be further identified as mild or severe:
- Cholestyramine and metoclopramide (cholesterol-lowering agents) (mild)
- Certain non-narcotic analgesic like Diflunisal (mild)
- Anticonvulsant drugs – Amobarbital, Butalbital, Pentobarbital, Phenobarbital, Secobarbital, Carbamazepine (mild)
- Antibiotics such as quinoline, isoniazid (mild)
- Increased possibility of toxicity with long-term administration of hydantoins, rifampin. (severe)
- Steroids (mild): increases the risk of gastrointestinal bleeding.
- Other non-steroidal anti-inflammatory agents like aspirin, ibuprofen (severe): as increased NSAIDs concentration in blood can lead to gastric irritation and bleeding in some cases.
- Diuretics (drugs used to increase the rate of urine excretion) (mild): increases the chances of kidney damage.
- Drugs used to lower blood sugar level in diabetes patients (mild)
- Methotrexate (used to treat cancer, arthritis) (severe): as it can lead to bleeding and breathing problem if taken with Combiflam
- Ciclosporin and Tacrolimus (drugs used to suppress the immune system)
- Zidovudine (a drug used to treat HIV) (mild)
- Medicines used to treat high blood pressure (antihypertensives) (mild)
- Digoxin (used to treat heart failure and irregular heartbeats)
3. Effects of Combiflam on Lab Tests
No effect on any lab tests apart from the potential damage to the liver in cases of repeated high doses
4. Combiflam’s interactions with Pre-existing Conditions/Diseases
Any allergic condition like rhinitis, urticaria, liver diseases or asthma, heart problems or bleeding disorder like Porphyria
Q. Can I have Combiflam with alcohol?
No. There is an increased risk of liver damage in chronic alcoholics. The consulting physician should be informed immediately if any signs are noticed that signifies bleeding in the stomach (dried and coffee coloured blood in cough or stools).
Q. Any particular food item to be avoided?
No particular food item needs to be avoided when consuming Combiflam.
Q. Can I have Combiflam when pregnant?
The doctor should always be notified if you are pregnant or plan to become pregnant as Combiflam is recommended for pregnant women.
Q. Can I have Combiflam when feeding a baby?
The doctor should always be informed if you are breastfeeding your child as a precautionary measure because Combiflam is not advised for a lactating mother.
Q. Can I drive after taking Combiflam?
One can drive after taking Combiflam but should avoid driving if any dizziness or drowsiness occurs.
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10Combiflam Composition, Variant and Price – Buyer’s Guide
|Combiflam Variants||Combiflam Composition||Combiflam Price (Rs.)|
|Combiflam Tablet||Ibuprofen 400 MG, Paracetamol 325 MG||Rs. 28.63 for 20 tablets|
|Combiflam Syrup||Ibuprofen 100 MG, Paracetamol 162.5 MG||Rs. 27.78 for 60 ML|
|Combiflam Plus Tablet||Paracetamol 650 MG, Caffeine 50 MG||Rs. 9.5 for 4 tablets|
|CombiflamIcyHot 15GM Gel||Diclofenac Diethylamine 1.16%w/w,methyl salicylate 10%w/w, Menthol 5% w/w, Virgin linseed oil 3%w/w||Rs. 50|
|CombiflamIcyHot 35GM Spray||Diclofenac Diethylamine 1.16%w/w, methyl salicylate 10%w/w, Menthol 5% w/w, Virgin linseed oil 3%w/w||Rs. 115|
Buy & Get Upto 20% Off: Use 1mg Coupon Code | Netmeds Coupon Code
11Substitutes of Combiflam
The following are alternative drugs for Combiflam:
- Brupal Forte Tablet
- Manufactured by – Geno Pharma
- Price – Rs. 10 for 10 tablets
- Brufamol Tablet
- Manufactured by – Menarini India Pvt Ltd
- Price – Rs. 10.7 for 10 tablets
- Ibuflamar P Tablet
- Manufactured by – Indoco Remedies Ltd
- Price – Rs. 20 for 15 tablets
- Ibugesic Plus Tablet
- Manufactured by – Cipla
- Price – Rs. 15.5 for 15 tablets
- Flexon Tablet
- Manufactured by – Aristo Pharmaceuticals Pvt Ltd
- Price – Rs. 20.1 for 15 tablets
Storage Requirements for Combiflam Tablets
- The drug should be stored in a cool, moisture-free place at the temperature below 25o
- The drug should be kept in a place where it is out of the reach of children.
12FAQs – 10 Important Questions Answered about Combiflam
Q. What is Combiflam?
Ans. Combiflam is basically not a solo drug; it is a combination of two drugs: Ibuprofen and Paracetamol.
It serves a dual purpose as it has got both analgesic (reduces pain) and antipyretic (reduces fever) properties. It is used mostly to treat mild to moderate pain. It can also be used in cases of fever as it has got antipyretic properties as well.
Q. What are the uses of Combiflam?
Ans. Combiflam works both for pain as well as fever. It is usually taken in cases of a headache, muscular pain, menstrual cramps, and toothache.
Q. What are the side effects of Combiflam?
Ans. The most common side effects of Combiflam are heartburn, vertigo, nausea, diarrhea, and constipation. There are a few other side effects which are comparatively less common. These include dizziness, discomfort in the upper abdomen, indigestion, insomnia, abdominal pain, vomiting, ulcer in the moth and yellowing of eyes/skin.
Q. How effective is Combiflam?
Ans. Combiflam is effective as a painkiller due to its analgesic properties. However as an antipyretic, there are other medicines which perform better when used to treat fever.
Q. How long does it take for Combiflam to show results?
Ans. Combiflam provides relief in fever and pain within 30-45 minutes of administration of the drug.
Q. Should Combiflam be taken on an empty stomach?
Ans. It should not be taken empty stomach as the components can cause stomach irritation and bleeding in rare cases of patients already suffering from gastric ulcer or any other gastric problems
Q. Does Combiflam make you drowsy?
Ans. In a few cases, it can cause drowsiness, but it varies with every individual
Q. What should be the time gap between the intake of 2 Combiflam Tablets?
Ans. The ideal time gap of at least 4-6 hours should be there between two doses to avoid Combiflam toxicity
Q. Should I complete the whole cycle of the medicine even if cured?
Ans. Combiflam provides relief from symptoms like fever and pain, if the symptoms disappear completely, one can turn down the medicine cycle gradually.
Q. Does Combiflam effect my menstrual cycle?
Ans. The effects of Combiflam on menstrual cycle are not known. Do consult with the doctor in case of pre-existing menstrual problems before consuming the drug
Q. Is Combiflam safe for children?
Ans. Combiflam in children below 1 year should not be administered without consulting Paediatrician. Children are not able to take the tablets. Therefore, Combiflam syrup can be advised in such cases. Maximum dose per day for Children below 1 year is 40-60mg/kg/day.
Q. Are there any symptoms that I should consider before taking Combiflam?
Ans. Gastric irritation and liver problems should be taken into consideration before taking Combiflam
Q. Is Combiflam legal in India?
Ans. Yes, it is legal and manufactured by Sanofi India Ltd.
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Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.