Combivir: Uses, Dosage, Side Effects, Price, Composition, Precautions & More

Combivir Composition – Lamivudine (150mg) + Zidovudine (300mg)
Manufactured By – Glaxo Smithkline Pharmaceuticals Ltd
Prescription – Prescription Required
Form – Tablet
Price – Rs 911.12
Quantity – 10 tablets in 1 strip

What is Combivir?

Combivir belongs to a class of anti-retroviral. It is a combination medicine used to treat human immunodeficiency virus (HIV) infection. Combivir is not a cure for HIV and only prevents the virus from multiplying in the body.

Manufactured By – Glaxo SmithKline Pharmaceuticals Ltd

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Uses of Combivir

Combivir is prescribed for HIV virus which causes AIDS

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Combivir Composition

It contains a combination of 150mg Lamivudine and 300mg Zidovudine.


How Does Combivir Work?

  • Combivir works by stopping the human immunodeficiency virus (HIV) from multiplying.
  • This inhibition helps in reducing the chances of development of acquired immunodeficiency syndrome (AIDS) and other HIV-related illnesses.

Combivir Prices In India

Specifics  Combivir Price
Strip of 10 tablets of 150mg / 300mg Rs. 911.12

 

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How to Take Combivir?

Combivir is administered orally in the form of tablets, with or without food.


Common Dosage of Combivir

  • Each Combivir tablet contains 300 mg of Zidovudine and 150 mg of Lamivudine.
  • This medicine is usually taken at a dose of one tablet twice daily, with or without food in adults and adolescents above 30kg
  • Patients weighing less than 30kg and with severe liver and kidney disease should not administer Combivir.

When to Avoid Combivir & Precautions to Take?

  • Avoid using Combivir if you are allergic to it or to any other ingredient present in this medicine.
  • Combivir is not recommended for use in patients suffering from renal impairment and liver impairment.
  • Patients with a history of bone marrow suppression and myopathy need to be cautious while using this medicine.
  • This medicine can increase the risk of lactic acidosis and may also cause fat gain or fat loss from the body.
  • Patients receiving this medicine may continue to develop infections and other complications associated with HIV infections.
  • Combivir may cause osteonecrosis. The risk of osteonecrosis is high in adult patients with advanced HIV-disease.
  • Patients with a history of pancreatitides, such as alcohol abuse or hypertriglyceridemia, should be monitored closely during therapy with this medicine.

Side Effects of Combivir

Some of the reported side effects of Combivir are:

  • Chills and fever
  • Sore throat
  • Pale skin
  • Unusual tiredness
  • Diarrhea
  • Rash
  • Nausea
  • Vomiting
  • Headache
  • Weight loss
  • Heartburn
  • Abdominal and stomach cramps
  • Loss of appetite
  • Stuffy nose
  • Muscle pain
  • Difficulty in falling asleep
  • Cough
  • Low red blood cell count (Anaemia)
  • Low white blood cell count (increased chances of infection)
  • Liver problems

What Are The Effects of Combivir on Organs?

  • Nervous system reactions- Headache, somnolence, dizziness, paresthesia, and taste perversion
  • Respiratory reactions- Cough, throat and tonsil discomfort and pain, bronchitis, sinusitis, breathing disorders, upper respiratory inflammation.
  • Musculoskeletal reactions- Myalgia, arthralgia.
  • Hepatic reactions-Abnormal liver function tests.
  • Hematologic reactions- Neutropenia, anemia, lymphatic signs, decreased white cells.
  • Metabolic reactions- Anorexia and decreased appetite.
  • Dermatologic reactions- Rash, diaphoresis, sweating, fungal skin infection, acne and folliculitis, viral skin infection.

Are There Any Reported Allergic Reactions?

Symptoms of allergic reactions due to Combivir are:

  • Hives
  • Itching
  • Wheezing
  • Swelling of face or throat

Drug Interactions to be Careful About

  • Do not take Combivir with any other medicine that contains lamivudine, zidovudine such as Atripla, Cimduo, Complera, Descovy, Emtriva, Genvoya, Odefsey, Retrovir, Stribild, and Trizivir.
  • Avoid taking medications that contain sorbitol, often used as a sweetener in liquid medicines.
  • Avoid drugs that can affect the bone marrow, decreasing the production of white and red blood cells such as Avlosulfon, ganciclovir, interferon-alpha and ribavirin, valganciclovir (Valcyte), valproic acid.
  • Aspirin, codeine, morphine can also affect the metabolism of Combivir.
  • Antibiotic clarithromycin can reduce the absorption of Combivir. This can be avoided by taking either of the two medications at least two hours apart.

Shows Effects/ Results In

  • Combivir contains two drugs (AZT and 3TC) which belong to a group of drugs called nucleoside analogues.
  • AZT and 3TC interfere with an enzyme called reverse transcriptase, which is used by HIV-infected cells to make new viruses.
  • Since both of these drugs inhibit or reduce the activity of this enzyme, Combivir causes HIV-infected cells to produce fewer viruses. Thus it does not treat the disease but slows its progression.

Storage Requirements for Combivir

  • Store Combivir between 2°C to 30°C.
  • Keep it in an air-tight container.
  • Keep it away from direct light or moisture.
  • Keep it out of reach of children.

Pro Tips When Taking Combivir

  • Continue to take all HIV medications as prescribed by your doctor.
  • Use an effective barrier method (latex condoms etc) during all sexual activity.
  • Do not share personal items (such as needles or syringes, toothbrushes, and razors) that may have contacted blood or other body fluids.
  • Long term use of Combivir may weaken your immune system and may cause signs of infections like fever, oral ulcers, skin sores along with muscle weakness.

FAQs

Is Combivir addictive?

No.

Can I have Combivir with alcohol?

Concomitant uptake of Combivir with alcohol may increase the risk of liver-associated side effects thus avoid the use of alcohol.

Any particular food item to be avoided?

No

Can I have Combivir when pregnant?

Administration of Combivir in pregnancy reduces the risk of vertical transmission of HIV in foetus however it is also associated with increased embryotoxicity and fetal malformation and thus should be avoided.

Can I have Combivir when feeding a baby?

HIV infected mothers administering Combivir should avoid breastfeeding their infants because of the potential of serious adverse reactions.

Can I drive after taking Combivir?

No.

What happens if I overdose on Combivir?

An overdose of Combivir may cause fatigues, headache, vomiting or hematological disturbances.

What happens if I eat expired Combivir?

An expired drug may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use an expired drug.

What happens if I miss a dose of Combivir?

If you miss a dose of Combivir, skip it and continue with your normal schedule. Do not double dose for a missed one.

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