cotrimoxazole: Uses, Dosage, Price, Side Effects, Precautions & More

What is Co-Trimoxazole?

Chloramphenicol is an antibacterial medication used to treat a variety of bacterial infections.

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What does Co-trimoxazole contain?

Co-trimoxazole is a combination of two drugs namely trimethoprim and sulfamethoxazole.

Uses of Co-Trimoxazole

Co-trimoxazole is used in the treatment of:

  • Lung infection
  • Infection of the airway tubes
  • Infection of the urinary pathway
  • Ear infection
  • Infection of intestines
  • Travelers’ diarrhea
  • Impetigo (red sores on the face)
Also Read: Clarithromycin Uses | Cyclophosphamide Uses

How Does Co-Trimoxazole Work?

Folic acid is produced and used by bacteria to carry out the reproduction process. Co-trimoxazole blocks the production of folic acid by bacteria thereby preventing the multiplication of bacteria. This results in stopping of the spread of infections.

How to Take Co-Trimoxazole?

  • Take Co-trimoxazole as a whole with a glass of water.
  • Remember not to crush, chew or break this medicine while consuming it.
  • If you are prescribed with suspension form then take it in the exact amount as prescribed by your doctor.

Co-Trimoxazole Price In India

SpecificsCo-Trimoxazole Price
400 mg/80 mg Strip of 10 TabletsRs 8
Also Read: Chlorpheniramine Maleate Price | Chlorthalidone Price

Common Dosage for Co-Trimoxazole?

It is most commonly prescribed twice daily. Your dosage and frequency may vary depending upon the severity of your condition.

When to Avoid Co-Trimoxazole?

Avoid Co-trimoxazole if:

  • You are allergic to any component of Co-trimoxazole
  • You have low blood platelet count
  • You have an abnormal level of RBCs
  • You have phenylketonuria
  • You have liver or kidney disease

Side-Effects of Co-Trimoxazole

Some of the reported side effects of Co-trimoxazole are:

  • Nausea
  • Diarrhea
  • Skin rashes
  • Stomach disturbance
  • Decrease in WBCs
  • Low blood cell count
Also Read: Cyclosprine Side Effect | Danazol Side Effect | Dapsone Side Effect

Effects of Co-Trimoxazole on Organs?

Co-trimoxazole is not suitable for patients with kidney or liver impairment. It may cause damage to these organs and your doctor may adjust your dose.

Are There Any Reported Allergic Reactions?

Some of the allergic reactions associated with Co-trimoxazole capsule are rashes and itching of skin, swelling of any part of face, tongue or throat, and shortness of breath.

Drug Interactions to Be Careful About

One needs to be careful about the following drug interactions with Co-trimoxazole:

  • Warfarin
  • Phenytoin
  • Methotrexate
  • Nitrites
  • Azilsartan

Effects/Results After Consuming co-trimoxazole

The effects of Co-trimoxazole can be seen within 1 to 2 hours of oral administration.

Things to Know About Co-Trimoxazole


Is Co-Trimoxazole addictive?

No, Co-trimoxazole is not addictive in nature.

Can I have Co-Trimoxazole with alcohol?

It is better to avoid alcohol when on Co-trimoxazole. Consult your doctor about limiting alcohol with this medication.

Any particular food item to be avoided?

Consult your doctor regarding the foods to be avoided when on Co-trimoxazole.

Can I have Co-Trimoxazole when pregnant?

In most cases, it is not safe to take Co-trimoxazole if you are pregnant or planning a pregnancy. Consult your doctor if it is absolutely necessary to take this medication.

Can I have Co-Trimoxazole when feeding a baby?

In most cases, it is not safe to take Co-trimoxazole if you are breastfeeding or planning to breastfeed. Consult your doctor if it is absolutely necessary to take this medication.

Can I drive after taking Co-Trimoxazole?

It is generally safe to drive while on Co-trimoxazole. However, if you feel any side effects that may decrease your alertness then it is not wise to drive.

What happens if I overdose on Co-Trimoxazole?

Taking more medication than prescribed is not going to heal you faster. In fact, overdose will result in severe side effects.

What happens if I eat expired Co-Trimoxazole?

If by mistake you consume a dose of expired Co-trimoxazole, the chances of harm are very less. Always check the label for expiry date before use.

What happens if I miss a dose of Co-Trimoxazole?

As soon as you remember, take the missed dose. However, if it is already time for the next dose, carry on with your regular schedule. Do not try to compensate for the missed dose by taking a double dose.

Storage Requirements for Co-trimoxazole

  • Store Co-trimoxazole between 25 to 30 degree Celsius
  • Place the cap of oral suspension tightly after use
  • Protect this drug from direct sunlight and moisture
  • Avoid storing oral formulations in bathroom or moisture prone areas.

Pro Tips When Taking Co-Trimoxazole

  • Complete the full course of Co-trimoxazole even if your symptoms have disappeared.
  • For best results always consume this medicine either an hour before or 2 hours after having a meal.
  • Do not try to self-adjust the dose. Take it in the quantity prescribed by your doctor.
  • Do not share your medication with anyone even if they have a similar condition.
  • Discuss the pros and cons of Co-trimoxazole if you are pregnant or planning a pregnancy or if you are breastfeeding.
  • Your doctor must know your medical history and allergies if any, before prescribing Co-trimoxazole.
  • This medication is not recommended for use in a child below 2 months of age.

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