Coxib: Uses, Dosage, Side Effects, Price, Composition, Precautions & More

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What is Coxib?

Coxib belongs to a class of medicines known as NSAIDs (nonsteroidal anti-inflammatory drugs). It is specifically a COX-2 inhibitor. It helps in relieving the pain and inflammation (redness, swelling) of osteoarthritis and rheumatoid arthritis. Coxib is less likely to irritate the stomach or gut than some of the older anti-inflammatory drugs, such as aspirin and indomethacin.

Manufactured By – Micro Labs Ltd

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Uses of Coxib Tablet

Coxib tablet is prescribed for:

  • Rheumatoid Arthritis
  • Osteoarthritis
  • Ankylosing Spondylitis
  • Dysmenorrhea (Menstrual pain and discomfort)
  • Acute pain
Read More: Colimex uses | Combivir uses | cyclodal uses

Coxib Composition

Coxib contains Cellecoxib as its active ingredient.


How Does Coxib Work?

  • Coxib is an NSAID which exerts anti-inflammatory (redness, swelling), analgesic( pain relieving) and anti-pyretic (fever lowering) activity.
  • Coxib helps relieve pain and inflammation by blocking cyclooxygenase enzymes, which are responsible for the synthesis of prostaglandins (prostaglandins are responsible for elevating body temperature and making nerve endings more sensitive to pain transmission).

Coxib Prices in India

Specifics  Coxib Price
Strip of 10 tablets of 90mg Rs. 33.33

How to Take Coxib?

  • Coxib is administered orally in the form of capsules and can be taken along with food or without it.
  • Do not chew or break the capsule, swallow it whole with water.
  • To avoid stomach upset, take the capsule after food.
  • Coxib should be administered at the lowest possible dose for the shortest duration of time.

Common Dosage of Coxib

  • The usual adult dose is 400 mg initially which is followed by 200 mg if needed on the first day. Later 200 mg tablet is given, twice daily as needed.
  • The dose for children (10-25kg) is 50 mg orally, administered twice a day And for children (more than 25kg), 100mg orally twice a day.
Also Read: Clopam dosage | deflox dosage | Demelan dosage

When to Avoid Coxib & Precautions to Take?

  • Avoid using Coxib if you are allergic to it or to other NSAIDs or to other components in it.
  • Coxib is not recommended in patients with a history of NSAID-induced asthma, rhinitis, and urticaria.
  • Patients at risk of cardiovascular disease should not take Coxib.
  • Coxib is contraindicated in patients who had heart surgery recently.
  • Coxib may cause gastrointestinal bleeding and impair kidney function.
Also Read: Ariol precautions | Althrocin Precautions | Citol Precautions

Side Effects of Coxib Tablets

Some of the reported side effects of Coxib tablets are:

  • Diarrhea
  • Stomach pain
  • Headache
  • Heartburn
  • Runny Nose
  • Flatulence
  • Dizziness
  • Back pain
  • Decreased appetite
  • Nausea
  • Rash

What Are The Effects of Coxib Tablets on Organs?

  • Gastrointestinal reactions- Abdominal pain, diarrhea, dyspepsia, flatulence, nausea.
  • Cardiovascular reactions- Peripheral edema, heart attack, stroke.
  • Dermatologic reactions- Rash.
  • Respiratory reactions- Bronchitis, bronchospasm, aggravated bronchospasm, cough, dyspnea, laryngitis, and pneumonia.
  • Genitourinary reactions- Urinary tract infection.

Are There Any Reported Allergic Reactions?

Symptoms of an allergic reaction due to Coxib tablet:

  • Hives
  • Rash
  • Wheezing
  • Trouble breathing
  • Swelling of face, throat

Drug interactions to be careful about

Concomitant use of following drugs is not recommended with Coxib tablet:

  • Corticosteroids
  • Adefovir
  • Antihypertensive (ACE inhibitors)
  • Fluconazole
  • Lithium
  • Methotrexate
  • Aspirin
  • Furosemide
  • Warfarin
  • Diuretics

Shows Effects/Results In

  • Coxib tablet inhibits the formation of chemical substances (prostaglandin) in the body that causes pain and swelling.
  • Coxib starts showing its peak effect within 2-3 hours following oral administration.

Storage Requirements for Coxib Tablet

  • Keep it in an air-tight container.
  • Keep it away from direct light or moisture.
  • Keep it out of reach of children.

Pro Tips When Taking Coxib Tablet

  • Coxib does not cause dependence.
  • Coxib is associated with fewer gastrointestinal-related adverse events compared to other NSAIDs that inhibit both COX-1 and COX-2 enzymes like Aspirin
  • Coxib tablet can increase the risk of heart attack and stroke especially in patients with a chronic long-term use or patients with pre-existing heart disease.

FAQs

Is Coxib addictive?

No, Coxib is not addictive.

Can I have Coxib tablet with alcohol?

No.

Any particular food item to be avoided?

No; not until your doctor tells you otherwise.

Can I have Coxib tablet when pregnant?

Use of Coxib tablet in pregnant women may increase the risk of foetal damage-like premature closure of foetal ductus arteriosus especially in the third trimester of pregnancy.

Can I have Coxib tablet when feeding a baby?

Coxib tablet is usually secreted in breast milk at a low dose thus avoid the use of Coxib in nursing mothers.

Can I drive after taking Coxib tablet?

Yes. Coxib tablet does not usually affect your ability to drive.

What happens if I overdose on Coxib?

An overdose of Coxib may cause drowsiness, GI bleeding, nausea, high blood pressure, difficulty breathing and kidney failure.

What happens if I eat expired Coxib?

An expired drug may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use an expired drug.

What happens if I miss a dose of Coxib?

If you miss a dose of Coxib, skip it and continue with your normal schedule. Do not double dose for a missed one.

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