What is Cyproheptadine?
- Cyproheptadine is a first-generation antihistamine with additional anticholinergic, anti-serotonergic, and local anesthetic properties.
- It is used as antipruritic, appetite stimulant, anti-allergic, and for the post-gastrectomy dumping syndrome.
- Cyproheptadine relieves allergy symptoms caused by seasonal allergies, food or blood.
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Uses of Cyproheptadine
Cyproheptadine is prescribed for:
Allergy symptoms such as watery eyes, runny nose, itching eyes or nose, sneezing, hives, and itching.
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How does Cyproheptadine work?
- Cyproheptadine is a potent antihistamine or antagonist of the HA-receptor.
- Cyproheptadine competes with free histamine for binding at HA-receptor sites which antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding.
- This drug also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations.
How to take Cyproheptadine?
- Cyproheptadine is administered orally in the form of tablet or syrup, 2 or 3 times a day.
- Measure the dose while taking liquid form, using a special measuring device or spoon.
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Common dosage of Cyproheptadine
- Recommended initial dose is 4 mg orally three times a day.
- Maintenance dose range is 12 to 16 mg per day, occasionally up to 32 mg per day but not to exceed 0.5 mg/kg per day.
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When to avoid Cyproheptadine & Precautions to take?
- Avoid using Cyproheptadine if you are allergic to it or any other inactive ingredients present along with it.
- Before using this medication, tell your doctor if you have breathing problems, glaucoma, heart disease, high blood pressure, kidney disease, seizures, ulcers, blockage, overactive thyroid (hyperthyroidism), difficulty urinating.
- Cyproheptadine drug may make you dizzy or drowsy or blur your vision.
- Liquid product of this drug may contain alcohol or sugar. Caution is advised if the patient has diabetes, liver disease, or any other condition.
- Cyproheptadine can often cause excitement in young children instead of drowsiness.
- Elderly patients may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, constipation, confusion, or trouble urinating.
- During pregnancy, this medication should be used only
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Side Effects of Cyproheptadine
- Blurred vision
- Increased appetite
- Weight gain
Effect on organs?
- Central nervous system reactions- Sedation, sleepiness, dizziness, disturbed coordination, confusion, restlessness, excitation, nervousness, tremor, irritability, sleeplessness, tingling, convulsions, emotional state, hallucination and faintness.
- Dermatological reactions- Rash, edema, excessive sweating, hives and photosensitivity.
- Ocular and ENT reactions- Blurred vision, double vision, fainting and ringing in the ear.
- Cardiovascular reactions- Low blood pressure, palpitations, fast heart rate and shock.
- Hematological reactions- Anemia and decrease in white blood cells and platelets.
- Gastrointestinal reactions- Liver failure, dryness of mouth, stomach distress, loss of appetite, nausea, vomiting, diarrhea, constipation and jaundice.
- Genitourinary reactions- Urinary frequency, difficulty in urination, urinary retention and early menses.
- Respiratory reactions- Dryness of nose and throat, sputum, tightness of chest, wheezing and nasal stuffiness.
- Other reactions- Fatigue, chills, headache and increased appetite/weight gain.
Reported allergic reactions?
Allergic reactions may include:
- Trouble breathing
- Swelling of face, throat, hands/legs
Drug interactions to be careful about?
- Cyproheptadine is well-absorbed following oral ingestion, after 1 to 3 hours. I
- Its effect when taken orally is approximately for 8 hours.
Storage Requirements for Cyproheptadine
- Keep it in an air-tight container.
- Keep it away from direct light or moisture.
- Keep it out of reach of children.
Pro Tips when taking Cyproheptadine
- Cyproheptadine medication should not be used in newborn or premature infants.
- Avoid consuming alcohol or tobacco or any other sleep-inducing drug while receiving this medicine.
- Do not drive or perform any activity due to side effects like drowsiness.
Is Cyproheptadine addictive?
Can I have Cyproheptadine with alcohol?
Any particular food item to be avoided?
Can I have Cyproheptadine when pregnant?
Yes; only if benefit outweigh the risks.
Can I have Cyproheptadine when feeding a baby?
Can I drive after taking Cyproheptadine?
What happens if I overdose on Cyproheptadine?
Overdose of Cyproheptadine may cause CNS depression, blurred vision, constipation, tachycardia, difficulty passing urine.
What happens if I eat expired Cyproheptadine?
Expired Cyproheptadine may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use expired drug.
What happens if I miss a dose of Cyproheptadine?
If you miss a dose of Cyproheptadine, skip it and continue with your normal schedule. Do not double dose for a missed one.