Diclofenac sodium: Uses, Dosage, Side Effects, Precautions & More

What is Diclofenac Sodium?

  • Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID) which reduce pain, fever and signs of inflammation like swelling, redness.
  • Diclofenac works by obstructing the production of enzyme called as Cyclo-oxygenase which helps in Prostaglandin synthesis.
  • Synthesis of Prostaglandins in the body is associated with symptoms like pain, fever, swelling etc.
  • Therefore by inhibiting the synthesis of prostaglandins, Diclofenac sodium helps in relieving all associated symptoms (pain, swelling etc).
  • Diclofenac is available in the following forms:
  • Tablets
  • Gel
  • Suppositories
  • Injection
  • Ophthalmic solution

Manufactured By – Blue Cross Laboratories Ltd
Other variants and compositions

Variant Composition
Diclofenac 75Mg Injection Diclofenac 25 MG /ML
Diclofenac 50Mg Zim Labs Tablet Diclofenac 50 MG
Buy & Get Minimum 20% Discount: Myra MedicinesNetmeds

Uses of Diclofenac Sodium

Diclofenac sodium tablets relieve pain, reduce swelling and ease inflammation in conditions affecting the joints, muscles and tendons including:

  • Rheumatoid arthritis
  • Osteoarthritis
  • Acute gout
  • Ankylosing spondylitis (arthritis affecting spine and large joints)
  • Backache
  • Sprains and strains
  • Soft tissue sports injuries
  • Frozen shoulder, Dislocations
  • Fractures
  • Tendonitis (inflammation of tendon for example tennis elbow)
  • Bursitis (inflammation of sacs filled with lubricating fluid in joints)
  • Dental pain
  • Muscle pain
  • Painful menses

Diclofenac may also be used for purposes not mentioned above.

Also read:  Dicyclomine Hydrochloride Uses | Drotin Ds Uses | Dolonex Dt Uses

Diclofenac Sodium Price in India

Specifics Diclofenac Sodium Price
50/500 mg Strip of 10 Tablets Rs 57
3 ml Injection Rs 9.9

How to take Diclofenac Sodium? 

Diclofenac sodium tablets comes in various forms:

Diclofenac sodium enteric coated (gastro-resistant) tablets-

  • These tablets have a special coating which allows it to pass through the stomach without dissolving, thereby reducing the risk of stomach irritation and indigestion.
  • These tablets are usually taken two or three times a day or as directed by your doctor.
  • These tablets should be swallowed as a whole and not broken, crushed or chewed.
  • They can be taken either with or without food and with plenty of fluids.
  • Antacids should not be concomitantly used with these tablets as antacids can stop the special stomach-protecting coating of the tablet from working.

Diclofenac sodium modified release (extended release) tablets

  • Diclofenac sodium modified release (extended release) tablets contain higher doses of diclofenac and are designed to release the content slowly and continuously over a few hours to provide prolonged relief from inflammation and pain.
  • Diclofenac sodium modified release (extended release) tablets are usually taken once or twice a day.
  • They should be taken with or after food or a drink of milk as taking empty stomach may cause gastric side effects.

Diclofenac sodium dispersible tablets-

  • Diclofenac sodium dispersible tablets are dissolved in water and consumed usually 2-3 times a day, or as directed by your doctor.
  • Dispersible tablets relieve pain faster than other types of diclofenac tablet, but are more likely to irritate the stomach.
  • They shouldn’t be used for longer than three months.
  • The tablet should be taken with or after food or with a glass of milk to help avoid irritation of the stomach.


  • A suppository is a form of medicine that is inserted into the rectum, vagina or urethra, where it dissolves or melts and is absorbed into the bloodstream through the rich supply of blood vessels found in this area, thereby exerting its effects.
  • Suppositories are particularly beneficial for people who can’t take diclofenac orally, for example patients who have just had an operation.
  • These suppositories melt in the rectum and diclofenac.

Diclofenac injections

  • Diclofenac can also be injected in patients where administration by mouth is not possible or where immediate effect is needed for example pain following surgery. The injection can be given into a muscle or via a drip into a vein (intravenous infusion).

Common dosage of Diclofenac Sodium

  • The drug dosage is decided by the physician based upon:
  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • Use the lowest possible dose for shortest duration whenever possible to reduce the risk of adverse effects when on Diclofenac therapy.
  • The most recommended adult dose being 100-200mg per day in divided doses depending upon the severity of symptoms.
  • In case of elderly 65 years and above, body may process this drug more slowly. So doctors usually start with a lowered dose so that too much of this drug does not build up in your body.
  • Consult your doctor before administering in children below 12 years of age.
  • Never use more than the recommended dose or for longer periods of time without doctor’s consent.
  • In case of non improvement of symptoms or symptoms getting worse, seek medical attention immediately.
Also Read:  Dexamethasone Dosage |  Dexorange Dosage | Deriphylline Dosage

Precautions- When to avoid Diclofenac Sodium

  • Allergy – Diclofenac Sodium is not recommended if you have a known allergy of medicines belonging to NSAIDs. Severe allergic conditions like Asthma and itching can be triggered in such cases.
  • Peptic Ulcer – in patients suffering from peptic ulcer, Diclofenac can cause severe swelling and bleeding in the stomach, colon and anus.
  • Diclofenac Sodium is not recommended for relieving pain after Coronary
  • Artery Bypass Surgery.
  • Patients suffering from asthma
  • Patients suffering from severe liver disease
  • Patients suffering from severe kidney disease

Side effects of Diclofenac Sodium

 All medicines have some side effects. Side effects are possible but do not always occur.

Consult your doctor if you feel that you have any of them:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Abdominal pain
  • Flatulence
  • Constipation
  • Heart burn
  • Diarrhoea
  • Dry mouth
  • Skin rash
  • Dry skin
  • Headache
  • Dizziness

Reported allergic reactions-

  • Diclofenac is not recommended if you are allergic to any of its active ingredient or other NSAIDs.
  • Possible allergic reactions reported are-
  • Rashes on skin
  • Breathlessness
  • Discoloration of the skin on the face or neck
  • Irregular heartbeat
  • Swelling of face, neck
  • Loss of consciousness

Effect on organs

  • It can cause fatal liver disease. Patients with pre-existing liver diseases should use this drug with caution and under supervision of their doctor.
  • In stomach it can cause ulcers which lead to serious bleeding from stomach or intestine.

Drug interactions to be careful about

  • Drug interaction refers to effect of drugs on each other and on human body after ingestion. Large numbers of medicines have shown to interact with each other.
  • It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used.
  • You must also inform about the herbal products that you are consuming. Do not modify the drug regimen without your doctor’s approval.
  • All the possible drug interactions might not be listed here. Few common drugs which interact with Diclofenac include:
  • ACE Inhibitors
  • Aldosterone antagonists
  • Alendronate
  • Amiloride
  • Aspirin
  • Beta blockers
  • Brimonidine
  • Calcineurin inhibitors
  • Corticosteroids
  • Cyclosporin
  • Fluconazole
  • Lithium
  • Loop diuretics
  • Methotrexate
  • Phenindione
  • Potassium
  • Prostaglandin analogues
  • Rifampicin
  • Tacrolimus
  • Thiazide diuretics
  • Triamterene
  • Warfarin

Show effects/Results in

  • It depends on the dosage and age of the patient and severity of the problem.
  • It shows its full effect in 30 minutes. Slowly leads to relief in pain.

Storage requirements Diclofenac Sodium

  • Store at room temperature away from light and moisture.
  • Do not freeze.

Pro Tips:

  • Diclofenac and other NSAIDs can increase the chance of heart attack in patients already suffering from heart disease when taken for longer durations.
  • Diclofenac should be cautiously used in patients with pre-existing peptic ulcer as it can cause bleeding in the stomach or intestine
  • NSAIDs should only be prescribed at lowest dose possible and for shortest time.
You may also check: Disodium Hydrogen Citrate | Disprin


Is it addictive?

  • No habit forming tendencies have been reported with this medicine.

Can I have diclofenac sodium with alcohol?

  • Daily use of alcohol while using this medicine may increase your risk for stomach bleeding.
  • Limit alcohol consumption and stop smoking. Ask your doctor about how much alcohol you may safely drink.

Any particular food item to be avoided?

  • No interaction with any food product observed. For further information you can consult your doctor.

Can I have diclofenac sodium when pregnant?

  • Tell your doctor if you are pregnant or if you plan to become pregnant.
  • During pregnancy avoid taking Diclofenac unless entirely necessary.
  • It is not recommended for use during first and third trimesters of pregnancy as it can harm the foetus or interference with normal delivery.

Can I have Diclofenac sodium when feeding a baby?

  • It is not known whether Diclofenac is secreted in breast milk.
  • Use with caution or only when advised in lactating mothers.

Can I drive after taking Diclofenac sodium?

  • Diclofenac Tablet may causes side effects like dizziness, headache, drowsiness and light-headedness in few patients.
  • In such patients, driving and operating heavy machinery should be avoided.

What happens if I overdose on Diclofenac?

  • Taking more than prescribed dosage can be harmful and can increase the incidence of side effects
  • Symptoms of over dosage include:
  • Nausea
  • Vomiting
  • Stomach discomfort
  • Drowsiness
  • Lethargy
  • In case of over-dosage, consult your doctor immediately.

What happen if I eat expired diclofenac sodium?

  • Avoid taking expired medicine. If you have taken accidentally and you are feeling any discomfort rush to the doctor immediately for medical assistance.
  • An expired drug might not be as potent in treating your condition. It is advisable to refrain from using expired drug.

What happen if I miss a dose of Diclofenac ?

  • The medicine may not work well if you miss a dose because for effective working of the drug, a certain amount of drug must be present in your body at all times.
  • Always consume the missed dose as soon as you remember it. But, if it is already time to take the second dose after that – do not take double dose.

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