What is Enalapril?
Enalapril is an ACE inhibitor (Angiotensin Converting Enzyme Inhibitors) which is used for the treatment of hypertension. For the treatment of essential or renovascular hypertension and symptomatic congestive heart failure. It may be used alone or in combination with thiazide diuretics.
Manufactured By – Dr Reddy’s Laboratories Ltd
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Uses of Enalapril
Enalapril is used to treat:
- Symptomatic heart failure
- Kidney problems.
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How does Enalapril work?
- Enalapril works by decreasing certain chemicals that tighten the blood vessels, so blood flows more smoothly and the heart can pump blood more efficiently.
- ACE inhibitors prevent the conversion of angiotensin I to angiotensin II by ACE, thereby attenuating the vasoconstrictive effects of angiotensin II peripherally (afterload reduction) and in the kidney (causing efferent arteriolar dilation).
- They also decrease the release of aldosterone into blood preventing sodium and water retention.
- ACE also is responsible for the breakdown of bradykinin (a vasodilator), and ACE inhibitors result in an accumulation of bradykinin, which may have beneficial vasodilatory effects.
How to take Enalapril?
- Enalapril is absorbed rapidly when given orally and has an oral bioavailability of ~60% (not reduced by food).
- Enalapril comes as an immediate and extended-release (long-acting) tablet to take by mouth.
- Enalapril can be taken with or without food; better is to take it at the same time each day.
Enalapril Price In India
|5 mg Strip of 10 Tablets||Rs 12.00|
Common Dosage for Enalapril
- It is usually taken once or twice a day (10 mg).
- The oral dosage of Enalapril ranges from 2.5-40 mg daily (single or divided dose), with 2.5 and 5 mg daily being appropriate for the initiation of therapy for heart failure and hypertension, respectively.
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When to avoid Enalapril?
- Taking Enalapril with Water tablets (potassium-sparing diuretics) such as spironolactone, eplerenone, triamterene or amiloride, may increase the levels of potassium in your blood.
- Medicines containing potassium (including dietary salt substitutes) and drugs like heparin and co-trimoxazole are not to be taken along with Enalapril.
- Medicines like beta-blockers, angiotensin-receptor-blockers, diuretics (thiazides, furosemide, and bumetanide), aliskiren or medicines for chest pain (nitroglycerine), if taken with Enalapril may lower blood pressure.
- Lithium, aspirin, thrombolytics can cause adverse effects if combined with Enalapril.
- Gold therapy can lead to flushing of your face, feeling sick (nausea), vomiting and low blood pressure, when taken with Enalapril.
Precautions when taking Enalapril
- ACE inhibition causes an increase in bradykinin levels, which putatively mediates angioedema.
- Do not take Enalapril if you have diabetes or impaired kidney function and are treated with a blood pressure lowering medicine containing aliskiren.
- If you are more than 3 months pregnant, avoid using Enalapril.
- Do not take Enalapril if you are allergic to it or any of its ingredients.
- Talk to your doctor if you have low blood pressure, heart failure, kidney or liver problem, or collagen vascular disease or are over 70 years of age.
Side Effects of Enalapril
Some of the reported side effects of Enalapril are:
- serum creatinine
- low blood pressure
- dry cough
Effects on organs?
- On heart – Hypotension, edema
- On nerves – A headache, Vertigo, fatigue, peripheral paresthesias, insomnia, dizziness, syncope.
- On kidney – Enalapril may worsen renal insufficiency, especially if the patient is hypovolemic or hypotensive. It increases serum creatinine, uric acid, and potassium.
- On lungs – Dry, nonproductive cough.
- On stomach and intestine – Nausea, vomiting, diarrhea.
- On skin – Pruritic, maculopapular eruption
Storage Requirements for Enalapril?
- Keep it in a dry, airtight container.
- Keep Enalapril away from direct heat or moisture.
- Keep it out of reach of the children.
Pro Tips when Taking Enalapril
- The first Enalapril tablet you take may make your blood pressure fall by more than doses you take after that.
- The first tablets may make you feel dizzy or light-headed. This effect becomes less likely with future doses.
- Exercise regularly for 30 minutes
Is Enalapril addictive?
No, Enalapril is not addictive.
Can I have Enalapril with alcohol?
No, Enalapril along with alcohol may cause your blood pressure to drop too much and you may feel dizzy, light-headed or faint.
Any particular food item to be avoided?
Food containing high potassium and salt levels need to be avoided.
Can I have Enalapril when pregnant?
No, Enalapril is a category D drug and if taken it will cause potential harm to the fetus.
Can I have Enalapril while feeding a baby?
No, it may cause harm to the infant.
Can I drive after taking Enalapril?
No, Enalapril may make you feel tired or dizzy.
What happens if I overdose on Enalapril?
Overdosing on Enalapril can cause dizziness or lightheadedness due to a fall in blood pressure, forceful and rapid heartbeat, rapid pulse, anxiety, cough, kidney failure, and rapid breathing.
What happens if I eat expired Enalapril?
It is advised to not to take expired medicines.
What happens if I miss a dose of Enalapril?
Take the next dose at the scheduled time. Never take more than the dose for a missed one.
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