Esgipyrin: Uses, Dosage, Composition, Side Effects, Price, Precautions & More

Esgipyrin Composition – Diclofenac 50 MG+Paracetamol 325 MG
Manufactured By – Abbott
Prescription – Prescription Required
Form – Tablet
Price – Rs 80
Quantity – 15 tablets in 1 strip

What is Esgipyrin?

Esgipyrin is an anti-inflammatory drug which reduce pain, fever and signs of inflammation like swelling, redness.

  • Esgipyrin contains the following drugs as chief ingredients –
  • Diclofenac – 50 mg,
  • Paracetamol / Acetaminophen – 500 mg

Manufactured By – Abbott

Uses of Esgipyrin

Esgipyrin tablets relieve pain, reduce swelling and ease inflammation in conditions affecting the joints, muscles and tendons including:

  • Rheumatoid arthritis
  • Osteoarthritis
  • Acute gout
  • Ankylosing spondylitis (arthritis affecting spine and large joints)
  • Backache
  • Sprains and strains
  • Soft tissue sports injuries
  • Frozen shoulder, Dislocations
  • Fractures
  • Tendonitis (inflammation of tendon for example tennis elbow)
  • Bursitis (inflammation of sacs filled with lubricating fluid in joints)
  • Dental pain
  • Muscle pain
  • Painful menses

How Esgipyrin works?

  • Esgipyrin contains Diclofenac and Paracetamol / Acetaminophen as chief ingredients.
  • Diclofenac Sodium is a pain killer and Paracetamol is an anti-pyretic that works by obstructing the production of enzyme called as Cyclo-oxygenase which helps in Prostaglandin synthesis.
  • Synthesis of Prostaglandins in the body is associated with symptoms like pain, fever, swelling etc.
  • Therefore by inhibiting the synthesis of prostaglandins, Esgipyrin helps in relieving all associated symptoms (pain, swelling etc).

How to take Esgipyrin?

  • These tablets are usually taken two or three times a day or as directed by your doctor.
  • These tablets should be swallowed as a whole and not broken, crushed or chewed.
  • They should be taken after food and with plenty of fluids.

Common dosage

The drug dosage is decided by the physician based upon:

  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • The standard recommended dosage is twice a day.
  • Consult your doctor before administering in children below 12 years of age.
  • Never use more than the recommended dose or for longer periods of time without doctor’s consent.
  • In case of non improvement of symptoms or symptoms getting worse, seek medical attention immediately.

When to avoid Esgipyrin?

  • Allergy – Esgipyrin is not recommended if you have a known allergy of medicines belonging to NSAIDs. Severe allergic conditions like Asthma and itching can be triggered in such cases.
  • Peptic Ulcer – in patients suffering from peptic ulcer, Diclofenac can cause severe swelling and bleeding in the stomach, colon and anus.
  • Esgipyrin is not recommended for relieving pain after Coronary Artery Bypass Surgery.
  • Patients suffering from asthma
  • Patients suffering from severe liver disease
  • Patients suffering from severe kidney disease

Drug interactions to be careful about

Drug interaction refers to effect of drugs on each other and on human body after ingestion. Large numbers of medicines have shown to interact with each other.

  • It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used.
  • You must also inform about the herbal products that you are consuming. Do not modify the drug regimen without your doctor’s approval.
  • All the possible drug interactions might not be listed here. Few common drugs which interact with Diclofenac include-
  • ACE Inhibitors
  • Aldosterone antagonists
  • Alendronate
  • Amiloride
  • Aspirin
  • Beta blockers
  • Brimonidine
  • Calcineurin inhibitors
  • Captopril
  • Clopidogrel
  • Corticosteroids
  • Cyclosporin
  • Dalteparin
  • Diclofenac
  • Enoxaparin
  • Fluconazole
  • Heparin
  • Ibuprofen
  • Lithium
  • Loop diuretics
  • Methotrexate
  • Phenindione
  • Potassium
  • Prostaglandin analogues
  • Rifampicin
  • Tacrolimus
  • Thiazide diuretics
  • Triamterene
  • Warfarin

Side effects 

All medicines have some side effects. Side effects are possible but do not always occur. Consult your doctor if you feel that you have any of them-

  • Nausea
  • Vomiting
  • Loss of appetite
  • Abdominal pain
  • Flatulence
  • Constipation
  • Heart burn
  • Diarrhoea
  • Dry mouth
  • Skin rash
  • Dry skin
  • Headache
  • Dizziness

Reported allergic reactions

Possible allergic reactions reported are-

  • Rashes on skin
  • Breathlessness
  • Discoloration of the skin on the face or neck
  • Irregular heartbeat
  • Swelling of face, neck
  • Loss of consciousness

Effect on organs

  • It can cause fatal liver disease. Patients with pre-existing liver diseases should use this drug with caution and under supervision of their doctor.
  • In stomach it can cause ulcers which lead to serious bleeding from stomach or intestine.

Show effects/Results in

  • It depends on the dosage and age of the patient and severity of the problem.
  • It shows its full effect in 30 minutes. Slowly leads to relief in pain.

Storage requirements

  • Store at room temperature away from light and moisture.
  • Do not freeze.

Pro Tips:

  • Diclofenac present in Esgipyrin can increase the chance of heart attack in patients already suffering from heart disease when taken for longer durations.
  • Esgipyrin should be cautiously used in patients with pre-existing peptic ulcer as it can cause bleeding in the stomach or intestine
  • NSAIDs should only be prescribed at lowest dose possible and for shortest time.


Is it addictive?

  • No habit forming tendencies have been reported with this medicine.

Can I have Esgipyrin with alcohol?

  • Daily use of alcohol while using this medicine may increase your risk for stomach bleeding.
  • Limit alcohol consumption and stop smoking. Ask your doctor about how much alcohol you may safely drink.

Any particular food item to be avoided?

  • No interaction with any food product observed. For further information you can consult your doctor.

Can I have Esgipyrin when pregnant?

  • Tell your doctor if you are pregnant or if you plan to become pregnant.
  • During pregnancy avoid taking Esgipyrin unless entirely necessary.
  • It is not recommended for use during first and third trimesters of pregnancy as it can harm the foetus or interference with normal delivery.

Can I have Esgipyrin when feeding a baby?

  • It is not known whether Esgipyrin is secreted in breast milk.
  • Use with caution or only when advised in lactating mothers.

Can I drive after taking Esgipyrin?

  • Esgipyrin Tablet may causes side effects like dizziness, headache, drowsiness and light-headedness in few patients.
  • In such patients, driving and operating heavy machinery should be avoided.

What happens if I overdose on Esgipyrin?

Taking more than prescribed dosage can be harmful and can increase the incidence of side effects including:

  • Symptoms of over dosage include:
  • Nausea
  • Vomiting
  • Stomach discomfort
  • Drowsiness
  • Lethargy
  • In case of over-dosage, consult your doctor immediately.

What happen if I eat expired Esgipyrin?

  • Avoid taking expired medicine. If you have taken accidentally and you are feeling any discomfort rush to the doctor immediately for medical assistance.
  • An expired drug might not be as potent in treating your condition. It is advisable to refrain from using expired drug.

What happen if I miss a dose of Esgipyrin?

  • The medicine may not work well if you miss a dose because for effective working of the drug, a certain amount of drug must be present in your body at all times.
  • Always consume the missed dose as soon as you remember it. But, if it is already time to take the second dose after that – do not take double dose.
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