Etodolac: Uses, Dosage, Price, Side Effects, Precautions & More

What is Etodolac?

Etodolac is an acetic acid derivative with some degree of COX-2 selectivity (selective COX-2 inhibitors are a type of nonsteroidal anti-inflammatory drug that directly targets cyclooxygenase-2, COX-2, an enzyme responsible for inflammation and pain).

Manufactured By – Alembic Pharmaceuticals Ltd

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Uses of Etodolac

Etodolac is used to treat:

  • Osteoarthritis
  • Rheumatoid arthritis
  • Mild to moderate pain
Other medicine's Uses: Gabapentin Uses | Guaifenesin Uses | Heparin Uses

How does Etodolac work?

  • Etodolac works by reducing the levels of prostaglandins (chemicals responsible for pain and fever and tenderness that often occur with inflammation).
  • Etodolac blocks the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain, and fever are reduced.

How to take Etodolac?

  • Take Etodolac by mouth.
  • Sustained-release preparations are available, allowing once-a-day administration.
  • Swallow the extended-release tablet whole. Do not crush, break, or chew it.
  • Take it with a glass of water.
  • To prevent irritation in the stomach, take Etodolac with food or milk.
  • Do not like lie down for at least 10 minutes after taking this drug.

Etodolac Price In India

Specifics Etodolac Price
400 mg Strip of 10 Tablets Rs 52.00
Also Read: Escitalopram Price | Fluoxetine Price

Common Dosage for Etodolac

  • Recommended dose 200-400 mg 3-4 times/day.
  • A single oral dose (200-400 mg) of Etodolac provides postoperative analgesia that typically lasts for 6-8 hours.
  • At anti-inflammatory doses, the frequency of gastric irritation may be less than with other NSAIDs.

When to avoid Etodolac?

  • Etodolac can interact with vitamins or herbs. Ask your doctor before taking any of these.
  • Taking Etodolac and arrhythmia drug (digoxin) together may increase your risk of kidney damage.
  • Taking Etodolac with ACE inhibitors (blood pressure drugs) can decrease the blood pressure lowering effects of these drugs.
  • Etodolac can reduce the diuretic effects of some diuretics drugs such as furosemide and hydrochlorothiazide.
  • Taking NSAIDs with Etodolac may increase the risk of stomach bleeding and ulcer.
  • Combination of Etodolac and blood thinner (warfarin) can be fatal causing stomach bleeding.
  • Taking Etodolac and lithium together may cause an increased amount of lithium in the blood which may cause tremors, confusion and excessive thirst.
  • Taking cyclosporine with Etodolac may increase the risk of kidney damage.

Precautions when taking Etodolac

  • Talk to your doctor before taking Etodolac if you are allergic to it or to any of the ingredients present in it.
  • This drug may cause high blood pressure. If you are already a high blood pressure patient, do not take this drug.
  • Avoid taking Etodolac if you are a heart or kidney patient. This may cause a risk to your health.
  • Asthma patients should also avoid taking Etodolac.
  • Dosage for children below 6 years of age is not yet established. Avoid giving Etodolac to children.

Side Effects of Etodolac

Some of the reported side effects of Etodolac are:

  • Gastrointestinal intolerance
  • Rashes
  • Constipation
  • Diarrhea
  • Dizziness
  • Blurred vision
  • Nausea
  • Painful urination
  • Abdominal pain
Also Read: Methylphenidate Side Effect | Methylprednisolone Side Effect

Effects on organs?

  • Gastrointestinal- Dyspepsia, abdominal pain, constipation, diarrhea, dyspepsia, heartburn, nausea, gastric ulcer, duodenal ulcer, vomiting, epigastric pain, gastritis, melena.
  • Renal- Renal function abnormal.
  • Nervous system- Dizziness, headache.
  • Skin- Pruritus, rash.
  • Hepatic- Liver enzymes increased.
  • Genitourinary- Dysuria, urinary frequency.

Storage Requirements for Etodolac

  • Keep it in a dry, airtight container.
  • Keep Etodolac away from direct heat or moisture.
  • Keep it out of reach of the children.

Pro Tips When Taking Etodolac

  • May also be used to relieve mild-to-moderate acute pain due to other causes.
  • Always use Etodolac at the lowest effective dose for the shortest possible time as directed by your doctor.
  • Taking Etodolac with food may decrease some of the gastrointestinal side effects.
  • Use sun protection creams to avoid sunburn (Etodolac can make your skin sensitive to the sun).
  • It may take up to 2 weeks before your symptoms improve. Keep using the medication as directed.


Is Etodolac addictive?

No, but taking it for longer periods may cause withdrawal symptoms such as a headache, tiredness.

Can I have Etodolac with alcohol?

No, Etodolac and alcohol together can increase the risk of stomach bleeding.

Any particular food item to be avoided?

No, not until your doctor advise you any.

Can I have Etodolac when pregnant?

No, Etodolac is a category C drug; it may cause harm to the fetus.

Can I have Etodolac while feeding a baby?

No, Etodolac passes through milk and cause risk to the development of the infant.

Can I drive after taking Etodolac?

No, Etodolac may cause dizziness which will decrease your alertness.

What happens if I overdose on Etodolac?

Overdosing on Etodolac may cause nausea, vomiting, and coma.

What happens if I eat expired Etodolac?

It is advised to not to take expired medicines.

What happens if I miss a dose of Etodolac?

Take the next dose at the scheduled time. Never take more than the dose for a missed one.

Also read about other medicine: Metoclopramide
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