Flucytosine: Uses, Dosage, Side Effects, Price, Composition, Precautions & More

Flucytosine: Uses, Dosage, Side Effects, Price, Composition, Precautions & More

What is Flucytosine?

  • Flucytosine is an anti-fungal medicine which is used to treat a wide variety of fungal infections.
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 Uses of Flucytosine

  • Fungal infections of-
  • Mouth or throat
  • Oesophagus
  • Genital tract
  • Toenails
  • Fingernails
  • Skin infections such as athlete’s foot and ringworm infections and certain kind of dandruff.
Read more: Asparginase Uses | Glycerine Uses

How does Flucytosine works?

Flucytosine is converted into 5-fluorouracil (5-FU), which is further converted to metabolites that inhibit fungal RNA and DNA synthesis, thereby stopping the fungal activity.

Also read: Dimethicone Composition

How to take Flucytosine?

  • Flucytosine is available in the form of capsules.
  • Take this medicine in the dose and duration as advised by your doctor.
  • Swallow it as a whole. Do not chew the capsule.
  • Flucytosine capsules should be taken with complete meals to avoid stomach upset.
  • Flucytosine should be taken 2 hours before or 1 hour after taking antacids as antacids may hinder the absorption of Flucytosine.
  • The use of Flucytosine should be continued as long as recommended by the doctor.

Common dosage?

  • The drug dosage is decided by the physician based upon:
  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • Consult your doctor before administering in children below 12 years of age.
  • Common dosage of Flucytosine – 50-150 mg/kg/day administered in divided doses at 6-hour intervals.
  • Never use more than the recommended dose or for longer periods of time without doctor’s consent.
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When to avoid Flucytosine?

Avoid taking Flucytosine if you have these conditions:-

  • Allergy to Flucytosine, or any other anti-fungal medicines.
  • Liver disease
  • Kidney disease
  • Heart disease (heart failure, coronary artery disease , heart valve disease)
  • Lung disease (chronic obstructive pulmonary disease)
  • Decreased or no stomach acid
  • Low levels of potassium or magnesium in blood.
  • Always inform your doctor if you have reduced testosterone levels, reduced cortisol levels or Addison’s disease.

Side effects-

All medicines have some side effects. Side effects are possible but do not always occur. Consult your doctor if you feel that you have any of them-

  • Nausea
  • Vomiting
  • Diarrhea
  • Gas in stomach
  • Stomach pain
  • Dry mouth
  • Bleeding in stomach
  • Jaundice
  • Anemia
  • Decrease in blood cell counts
  • Elevation of liver enzymes and bilirubin
  • Confusion
  • Hallucinations
  • Psychosis
  • Fatigue
  • Hypoglycemia
  • Heart block
  • Fever
  • Rash
  • Fatigue, muscle pain, joint pain
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Reported allergic reactions-

  • Flucytosine is not recommended if you are allergic to any active ingredient or constituents of it.
  • Possible allergic reactions reported are-
  • Sever skin rash
  • Difficult breathing
  • Swelling of your face, lips, tongue or throat

Effect on organs-

  • It can affect your liver so consult your doctor if any of these symptoms appear:-
  • Unusual fatigue
  • yellowing of the eyes and skin,
  • dark urine, fever,
  • nausea and / or vomiting,
  • pale stools,
  • and abdominal pain.

Drug interactions to be careful about-

  • You must inform your doctor about all the drugs, vitamins or herbal supplements you are taking to manage or protect you from drug interactions.
  • All the possible drug interactions might not be listed here. Few common drugs which interact with Flucytosine include:
  • Antacids
  • H2 blockers such as cimetidine
  • Immunosuppressive or cytostatic agents.
  • Myelosuppressive drugs, such as zidovudine, should be used with caution in patients receiving 5-FC
  • Aluminium hydroxide or magnesium hydroxide
  • Amphotericin b

Show effects/Results in-

Depends on the condition being treated.

Storage requirements for Flucytosine –

  • Capsules should be stored at room temperature 15-25 degree Celsius and protected from light and temperature.


Do not stop taking Flucytosine or change the dose of this drug without consulting your doctor.

You must immediately inform your doctor if you notice any signs of liver disease.

Also check out: Glycerine Price

Frequently asked questions

Is it addictive?

No habit forming tendencies have been reported with this medicine.

Can I have Flucytosine with alcohol?


Any particular food item to be avoided?


Can I have Flucytosine when pregnant?

  • It is not advisable to take Flucytosine when pregnant or planning to become pregnant.

Can I have Flucytosine when feeding a baby?

Flucytosine is not recommended for lactating woman as it is known to excrete in the breast milk.

Can I drive after taking Flucytosine?

  • This drug may make you dizzy and weak.
  • Kindly refrain from driving if you suffer from any such side-effects which affect your ability to drive.

What happen if I overdose on Flucytosine?

  • Taking more than prescribed dosage can be harmful and can increase the incidence of side effects
  • In case of over-dosage, consult your doctor immediately.

What happen if I eat expired Flucytosine?

An expired drug might not be as potent in treating your condition. It is advisable to refrain from using expired drug.

What happen if I miss a dose of Flucytosine?

  • You must take the missed dose as soon as you remember it.
  • But, if it is already time to take the second dose after that – do not take double dose.

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