What Is Gatifloxacin?

Gatifloxacin is an antibacterial drug which belongs to the 4th generation of fluoroquinolone antibiotics. It is indicated for bacterial infections in eyes such as conjunctivitis.

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Uses Of Gatifloxacin

  • Gatifloxacin comes in the form of eye drops which is used for treating bacterial conjunctivitis.
  • Gatifloxacin available in tablet form is used for the treatment of bronchitis, community-acquired pneumonia, urinary tract infections, skin and skin structure infections etc.
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How Does Gatifloxacin Work?

Gatifloxacin inhibits two major bacterial enzymes namely DNA gyrase and topoisomerase 4 due to which bacterial DNA can’t replicate and thus bacterial growth doesn’t occur further.

How to Take Gatifloxacin?

Eye drop

  • Wash your hands before and after using Gatifloxacin eyedrops.
  • Do not touch the tip of the container to contaminated objects or skin.
  • Tilt your head back and instill one drop of the drug into each eye.
  • After use, keep your eyes closed for about 1 to 2 minutes.


  • Gatifloxacin tablets are usually well absorbed orally and should be directly swallowed with water in one go.
  • They can be taken with or without food.
  • For ideal results, it should always be taken at evenly spaced intervals to maintain certain amount of drug in the body all the time.

Common Dosage Of Gatifloxacin

  • Adult dose for Gatifloxacin eye drop for conjunctivitis-

For 0.3% solution:

-Days 1 and 2: Instill 1 drop in the affected eye(s) every 2 hours upto 8 times a day.

-Days 3 through 7: Instill 1 drop in the affected eye(s) upto 4 times a day.

For 0.5% solution:

-Day 1: Instill 1 drop in the affected eye(s) every 2 hours upto 8 times a day.

-Days 2 through 7: Instill 1 drop in the affected eye(s) 2 to 4 times a day. 

  • In case of children, dose should be given as per doctor’s prescription.
  • Adult dose for bronchitis – 400mg Gatifloxacin for 5 days
  • Community acquired pneumonia – 400mg for 7-14 days
  • Skin and skin structure infections – 400mg for 7-10 days
  • Urinary tract infections (complicated) – 400mg for 7-10 days.
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When to Avoid Gatifloxacin & Precautions To Take?

  • Avoid using Gatifloxacin if you are allergic to this medicine or other fluoroquinolone groups of drugs.
  • Avoid taking if you suffer from tendinitis or tendon rupture.
  • Don’t wear contact lenses if you are suffering from bacterial conjunctivitis.
  • Patients suffering from kidney disease or on dialysis
  • Patients suffering from liver diseases
  • Patients having myasthenia gravis (abnormal weakness of muscles)
  • Patients with a heart problem or long QT interval (heart’s electrical cycle)

Side Effects Of Gatifloxacin

Common side effects with Gatifloxacin eyedrop include –

  • HeadacheBlurred vision
  • Taste disturbance
  • Dryness of eyes
  • Irritation of eyes
  • Discharge from eyes
  • Increased salivation

Other common side effects with the tablet form of Gatifloxacin include –

  • Nausea
  • Headache
  • Dizziness
  • Diarrhea
  • Abdominal pain
  • Mouth ulcer
  • Dry skin
  • Rash
  • Palpitations

What Are The Effects of Gatifloxacin on Organs?

No major systemic side effects occur with Gatifloxacin eye drops.

Are There Any Reported Allergic Reactions?

  • In case of allergy, immediately inform your doctor
  • Signs of an allergic reaction include rashes, itching; redness or peeling of skin, fever, tightness in the chest or throat, difficulty in breathing,unusual swelling of the mouth, face, lips, tongue, or throat.

Drug Interactions to be careful about?

Gatifloxacin may interact with drugs such as:

  • Aluminium Hydroxide
  • Magnesium Hydroxide
  • Digoxin
  • Warfarin
  • Omeprazole
  • Tizanidine
  • Phenytoin

Shows Effects/Results In

The onset of action of eye drops can be seen within a few minutes and may last up to 2 to 3 hours.

Storage  Requirements for Gatifloxacin

  • Store at room temperature.
  • Do not freeze the medicament.
  • Keep away from reach of children and pets.

Pro Tips When Taking Gatifloxacin

  • Do not use in larger amounts than prescribed.
  • Do not stop using Gatifloxacin before completion of the antibiotic course.


Is Gatifloxacin addictive?

No, Gatifloxacin is not addictive.

Can I have Gatifloxacin with alcohol?

The interaction of Gatifloxacin with alcohol is unknown.

Any particular food item to be avoided?


Can I have Gatifloxacin when pregnant?

Avoid taking Gatifloxacin when pregnant unless necessary as it may lead to adverse effects on foetus since there are no adequate and well-controlled studies in pregnant women.

Can I have Gatifloxacin when feeding a baby?

Avoid unless necessary as Gatifloxacin is excreted in breast milk and can cause adverse effects to the baby.

Can I drive after taking Gatifloxacin?

No, it is not recommended to drive after taking Gatifloxacin.

What happens if I overdose on Gatifloxacin?

Immediately inform your doctor if you take an overdose.

What happens if I take expired Gatifloxacin?

It may lead to irritation and redness of eyes. Wash your eyes well with water and inform your doctor if the irritation persists.

What happens if I miss a dose of Gatifloxacin?

Take the missed dose as soon possible. If it’s already time for your next scheduled dose, skip the missed dose.

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