What is Glipizide?
Glipizide tablets can either be used alone or in combination with insulin therapy or with other anti-diabetic medications like Metformin to reduce blood glucose levels in type 2 diabetics. Glipizide comes in tablet form (5mg, 10mg) and is available as immediate release and extended release tablet forms.
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Uses of Glipizide
- Glipizide is an oral anti-diabetic drug which is used to lower the blood glucose levels in type 2 diabetic patients
- Glipizide should be used as an adjunct to lifestyle changes (quitting smoking, alcohol, exercise etc.) and dietary changes for effective blood glucose control
- Glipizide should not be used in patients with type 1 diabetes (condition in which body does not produce insulin) and diabetic ketoacidosis with or without coma
Also Read: Entresto Uses
How does Glipizide work?
- Glipizide is an oral hypoglycaemic drug which belongs to Sulfonylurea group.
- Glipizide stimulates the release of insulin from the pancreas which is dependent on functioning beta cells in the pancreas.
- In addition, Glipizide also seems to have extra-pancreatic effects like the increased sensitivity of peripheral tissues to insulin and decrease of insulin uptake by the liver.
How to Take Glipizide?
- The dosage and duration of treatment with Glipizide are based on your age, the severity of the condition, physical health, and response to therapy.
- Glipizide is more effective when taken half an hour before the first meal (breakfast). For ideal results, it should always be taken at a fixed time.
- Avoid skipping meals when on anti-diabetic drugs as it may lead to hypoglycaemia.
- Non-pharmacologic therapy (dietary modification, weight control, and exercise) is equally essential to reduce blood glucose levels along with Glipizide therapy.
- The tablet should be swallowed as a whole without crushing, chewing or breaking it along with plenty of fluids.
- The medicine should not be stopped on your own without a doctor’s consent. Regular monitoring of blood sugar levels should be done to alter the dose.
- If it is taken as over the counter product, check the label for directions before use.
Glipizide Price In India
|Strip of 10 Tablets||Rs 200|
Also Read: Krill-Oil Price | Lantus Price
Common Dosage for Glipizide?
- There is no fixed dose regimen of Glipizide for the treatment of diabetes. Constant monitoring of blood glucose levels and dose variation accordingly is a must.
- To decrease the risk of adverse effects, your doctor may initially start from a low dose and gradually increase your dose based on your condition.
- The usual starting dose of Glipizide as initial therapy is 5mg orally once daily half an hour before the first meal.
- In geriatric patients and patients with liver disease, the initial starting dose can be reduced to 2.5mg.
- After reaching a dose of 5mg, dosage increment should be made in no more than 2.5mg – 5mg increment based on the glucose level of the patient.
- The maximum recommended dose is 40mg per day.
- Patients who do not respond adequately to the maximum dose of Glipizide can be administered with a combination of Glipizide and metformin or Glipizide and insulin combination therapy.
- It should be used with caution in patients with a history of liver and kidney disease and should be avoided in pregnant patients.
When to Avoid Glipizide?
Glipizide should be avoided or used with caution in:
- Patients with allergy to any of its components
- Type 1 diabetes (insulin dependent diabetes)
- Pregnant and lactating females
- Diabetic ketoacidosis
- Severe kidney or liver function disorders
- Patients with G6PD deficiency (genetic problem)
- Children below 18 years of age
Side-effects of Glipizide?
In addition to its intended uses, Glipizide may cause few undesirable side effects which may include:
- Hypoglycaemia – most commonly observed when calorie uptake of a patient is less, after prolonged exercise, alcohol intake or when the dose of anti-diabetic drug administered is more. Symptoms of hypoglycaemia (low blood glucose) include:
- Impaired concentration
- Tachycardia (increased heart beat)
Other less commonly observed side effects include:
- Loss of appetite
- Skin rash
- Abdominal pain
- Thrombocytopenia (decreased platelet count)
- Liver damage – jaundice, itchy skin, dark coloured urine, constant sleepiness
In addition, it may cause some other allergic or unwanted effects. In such cases, seek medical attention immediately.
Also Read: Humalog Side Effect | Hydrocodone Side Effect
Effect on organs?
- Heart – Administration of Glipizide and other hypoglycaemic drugs have been reported to be associated with increased cardiovascular mortality.
- Liver – Patients with the pre-existing liver disease should use Glipizide with caution as it can cause severe hepatic impairment.
Reported Allergic Reactions?
Allergic reactions with Glipizide have been reported. Inform your doctor if you are allergic to any of its ingredients. Signs of allergic reaction include:
- Rashes/itching of the skin
- Shortness of breath
- Swelling of face, lips, tongue, or throat
- Loss of consciousness
- Angioedema (painless swelling under the skin)
Drug Interactions to Be Careful About
Drug interactions refer to the effect of drugs on each other and on the human body after ingestion. There are large numbers of medicines which have shown to interact with each other. It is always advisable that the patient must inform the doctor about all the drugs/over the counter products/vitamin supplements used while using Glipizide. All the possible drug interactions might not be listed here. Few important drugs which interact with Glipizide are listed below:
- Oral contraceptives
- Calcium channel blockers
Using all these products along with Glipizide can influence the therapeutic effect of these medicines and also can increase the chances of side effects. Thus dose alteration or drug replacement might be needed when Glipizide is taken along with these drugs.
Shows Effects / Results In
- Glipizide starts showing its effect within 24-48 hours by reducing the blood glucose levels. However, the maximum effect takes some time depending upon the severity of the condition.
- A complete dose prescribed by your doctor must be taken for complete diabetes control even if symptoms have disappeared.
Is Glipizide addictive?
No habit forming tendency has been reported. However, over-dependence on these medicines should be avoided.
Can I have Glipizide with alcohol?
- Consumption of alcohol is not recommended when on Glipizide therapy as it may alter blood sugar levels.
- It is best not to drink alcohol when on Glipizide therapy. Consult your doctor for further recommendations.
Any particular food item to be avoided?
No alteration in its action seen with any food product.
Can I have Glipizide when pregnant?
- Glipizide is not recommended during pregnancy as abnormal blood glucose levels during pregnancy are associated with higher incidence of congenital abnormalities.
- Consult your doctor in case if you are pregnant or plan to become pregnant for case specific recommendations.
Can I have Glipizide when feeding a baby?
- Glipizide is not recommended for use while you are breast feeding as the drug may pass into breast milk and may harm the foetus by decreasing blood sugar levels.
- Consult your doctor for case specific recommendations.
Can I drive after taking Glipizide?
Glipizide intake doesn’t affect your ability to drive. However hypoglycaemia caused due to over dosage or skipping meals and hyperglycaemia due to improper dosage may cause drowsiness, fatigue, impaired concentration, sleepiness etc which may hinder with driving and operating heavy machinery.
What happens if I overdose on Glipizide?
- Glipizide should never be administered in more than prescribed dose.
- Taking more medication or with increased frequency may cause serious Hypoglycaemia (symptoms of which have been mentioned above)
- If suspected of an over-dosage, seek medical care immediately.
What happens if I take expired Glipizide?
- A single dose of expired Glipizide may not cause any major adverse effect. However, the potency of the medicine may well have decreased overtime and it may cause hyperglycaemia (increased blood glucose levels).
- Please inform your physician regarding the same if expired medicines have been taken chronically for a longer duration.
What happens if I miss a dose of Glipizide?
- The medicine may not work well if you miss a dose because a certain amount of drug must be present in your body at all times for its effective working,
- If you forgot to take a dose, take it as soon as you remember. But, if it’s already time to take the second dose – do not take a double dose.
Storage Requirements for Glipizide
- Store at a cool and dry place away from direct heat and moisture.
- Do not freeze the medicine.
- Keep medicines away from children and pets.
Pro Tips When Taking Glipizide
- Glipizide tablets should be administered along with non-pharmacologic therapy (proper dietary modification, weight control and exercise) to achieve the best results. In early type 2 diabetes, only nonpharmacologic therapy may well provide ideal results.
- Over a period of time, patients may become less responsive to oral antidiabetic drugs because of the deterioration of their diabetic state. Patients should, therefore, be monitored with regular lab tests like blood glucose levels and HbA1C to determine effective dosage.