Harvoni : Uses, Dosage, Side Effects, Price, Composition, Precautions & More

What is Harvoni(ledipasvir 90 mg/sofosbuvir 400 mg)?

  • Harvoni contains ledipasvir and sofosbuvir as its main ingredients.
  • Harvoni is indicated for the treatment of chronic hepatitis C virus in adults.
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Uses Of Harvoni

Harvoni is indicated for the treatment of treatment of chronic hepatitis C (a viral infection of the liver) in adults and in adolescents aged 12 to < 18 years.

How Does Harvoni Work?

  • Harvoni contains ledipasvir and sofosbuvir as its main ingredients.
  • Ledipasvir and sofosbuvir decreases the amount of hepatitis C virus in human body, which helps the body fight against infection and fastens recovery.
Also Read: Incruse Ellipta Composition

Harvoni Price in India

Specifics  Harvoni Price
Harvoni Tablet 28s Rs. 25000.00


Also Read: Fosamax Price | Ifosfamide Price 

How to Take Harvoni?

  • Harvoni is available in the form of tablets.
  • Tablets should be taken orally with or without food.

Common Dosage Of Harvoni

  • Harvoni should only be taken under doctor’s supervision.
  • Recommended dose – One tablet (90 mg of ledipasvir and 400 mg of sofosbuvir) taken orally once daily.
Also Read: Dolopar DosageFarxiga Dosage

Precautions-  When to Avoid Harvoni ?

  • Avoid using Harvoni if you are allergic to it or ledipasvir and sofosbuvir.
  • Always remember that If Harvoni is used in combination with ribavirin, all contraindications to ribavirin also apply to Harvoni combination therapy.
  • Always test all patients for confirmation of current or prior HBV infection before initiation of HCV treatment in order to avoid the risk of Hepatitis B virus reactivation.
  • Harvoni is not recommended for use in pediatric patients aged < 12 years,

Side Effects Of Harvoni

Common side effect include-

  • Headache
  • Rashes
  • Swelling on face and lips
  • Fatigue
  • Weakness
  • Diarrhea
  • Insomnia
Also Reads: Fosamax Side EffectsGleevec Side Effects

Effect Of Harvoni on Organs?

Dose modification is needed in patients suffering from advanced kidney diseases.

Reported Allergic Reactions?

Allergic reactions to Harvoni been reported. Symptoms include difficulty in breathing, severe skin rashes, headache, dizziness, dry mouth, fever etc. Seek immediate medical attention in such cases.

Drug Interactions to be careful about?

  • Harvoni may show interaction with several drugs.
  • Inform your doctor about all the medications you take before using Harvoni.

Most common drug interactions include –

  • Rifampin or St. John’s wart – may reduce the therapeutic effect of Harvoni
  • Antacids – e.g., aluminum and magnesium hydroxide
  • H2-receptor antagonists (e.g., famotidine)
  • Amiodarone
  • Proton-pump inhibitors – omeprazole, pantaprazole
  • Antiarrhythmics: amiodarone, digoxin
  • Anticonvulsants: carbamazepine, phenytoin, phenobarbital and oxcarbazepine
  • Antimycobacterials: rifabutin, rifampin, rifapentine
  • HIV Antiretrovirals – efavirenz, atazanavir, ritonavir
  • Rosuvastatin

Shows Effects/Results After Consuming Harvoni

Cannot be predicted.

Storage Requirements About Harvoni

  • Store in a cool place, away from heat and light.
  • Do not freeze the medication.

Pro Tips When Taking Harvoni

  • Take Harvoni only under medical supervision.
  • As liver functions might change, frequent monitoring of international normalized ratio (INR) values is recommended in patients receiving warfarin while taking Harvoni.

 FAQs – Things to Know About Harvoni

Is Harvoni addictive?


 Can I have Harvoni with alcohol?


Any particular food item to be avoided?


 Can I have Harvoni when pregnant?

No. As a precautionary measure, it is preferable to avoid the use of Harvoni during pregnancy.

Can I have Harvoni when feeding a baby?

No. It is unknown whether ledipasvir or sofosbuvir and its metabolites are excreted in human milk.

As a precautionary measure, it is preferable to avoid the use of Harvoni during breastfeeding.

Can I drive after taking Harvoni?


What happens if I overdose on Harvoni?

Seek immediate medical attention in case of overdosing with Harvoni.

Overdosing of Harvoni can cause significant breathing difficulties and loss of consciousness.

What happens if I eat expired Harvoni?

You must refrain from consuming an expired drug.

A single dose of expired tablet should cause no harm. Always consult your doctor for case based analysis.

What happens if I miss a dose of Harvoni?

Take the missed dose as soon as you remember it. Do not take double dose to make up for the missed dose.

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