Heparin: Uses, Dosage, Price, Side Effects, Precautions & More

Heparin: Uses, Dosage, Price, Side Effects, Precautions & More

Heparin Composition – Heparin (25000IU)
Manufactured By – Gland Pharma Limited
Prescription – Prescription Required
Form – Injection
Price – Rs 188.3
Quantity – 1 ml in 1 vial

What is Heparin?

Heparin is an anticoagulant (anticoagulants are used to treat and prevent thromboembolism. Anticoagulants do not break down preexisting clots but can prevent the formation of new clots). It is a complex mixture of large, water-soluble polysaccharide molecules of varying size. Heparin is a charged, large-molecular-weight drug that does not cross the placenta.

Manufactured By – Gland Pharma Limited
Other variants and compositions

Variant Composition
Heparin Sodium 5000 Iu Injection Heparin (5000IU)
Heparin 25000 Iu Injection Heparin (25000IU)
Heparin Sodium 10000 Iu Injection Heparin (10000 IU)
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Uses of Heparin

Heparin is commonly used to:

  • Prevent thromboembolism, especially in the hospital setting.
  • Heparin is used in cardiac bypass surgery to prevent clots in the extracorporeal circuit.
  • Heparin provides rapid anticoagulation, which is especially useful in preventing further clotting in patients with deep venous thrombosis or pulmonary embolism.
  • Heparin is also a good choice for anticoagulation during pregnancy because it does not cross the placental barrier.
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How does Heparin work?

  • Heparin increases the activity of anti-thrombin III, an endogenous molecule that inactivates thrombin (factor II) and factor Xa.
  • Increased activity of anti-thrombin III, inhibits the clotting cascade.

How to take Heparin?

  • Heparin is not absorbed following oral administration.
  • Subcutaneous injection (small volume; potentially painful) is commonly used for injection of Heparin.

Heparin Price In India

Specifics Heparin Price
10000 IU Vial of 10 ml Injection Rs 185.71
25000 IU Vial of 1 ml Injection Rs 188.3
5000 IU Vial of 5 ml Injection Rs 70.16
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Common Dosage of Heparin

  • Heparin is given by continuous intravenous infusion, intermittent infusion every 4-6 hours, or subcutaneous injection every 8-12 hours.
  • For therapeutic purposes, Heparin also can be administered subcutaneously on a twice-daily basis.
  • For low-dose Heparin therapy (to prevent DVT and thromboembolism in hospitalized medical or surgical patients), a subcutaneous dose of 5000 units is given two to three times daily.

When to avoid Heparin?

  • The risk of hemorrhage is increased when thrombolytics are used with Heparin.
  • Very high doses of Heparin are required to prevent coagulation during cardiopulmonary bypass.
  • Drugs such as acetylsalicylic acid, dextran, ibuprofen, indomethacin, and dipyridamole interfere with platelet aggregation reactions may induce bleeding and should be used with caution in patients receiving Heparin sodium.
  • Digitalis, tetracyclines, nicotine, antihistamines may partially counteract the anticoagulant action of heparin.
  • When Heparin sodium is given with dicumarol or warfarin sodium, at least 5 hours after the last intravenous dose should elapse before blood is drawn to get an accurate idea of any blood disorder or blood thinning.

Precautions when taking Heparin

  • Tell your doctor if you are allergic to it or any other ingredient present in it.
  • Heparin is not intended for intramuscular use.
  • Heparin is contraindicated in those with a risk of bleeding (especially in people with uncontrolled blood pressure, liver disease, and stroke), severe liver disease, or severe hypertension.

Side Effects of Heparin

  • Heparin’s major adverse effect is bleeding.
  • Less common side effects are heparin-induced thrombocytopenia (which may paradoxically present as clotting) and a rare immune reaction of skin necrosis at the site of injection.
  • Osteoporosis resulting in spontaneous vertebral fractures can occur, in patients who have received full therapeutic doses of heparin (>20,000 units/day) for extended periods (e.g., 3-6 months).
  • Heparin can inhibit the synthesis of aldosterone by the adrenal glands and occasionally causes hyperkalemia, even when low doses are given.

Effects on organs?

  • Cardiovascular- Chest pain, thrombosis, vasospasm.
  • CNS- Chills, dysesthesia (feet), headache, peripheral neuropathy.
  • Gastrointestinal- Constipation, hematemesis, melena, nausea, vomiting.
  • Endocrine- Adrenal hemorrhage, hyperkalemia, ovarian hemorrhage.
  • Skin- Dermal ulcer, eczema, localized erythema, skin necrosis, urticarial.
  • Respiratory- Asthma, bronchospasm, epistaxis, hemoptysis, rhinitis.

Storage Requirements for Heparin

  • Keep it in a dry, air tight container.
  • Keep it away from direct heat or moisture.
  • Keep Heparin out of reach of the children.

Pro Tips when taking Heparin

  • Must be given by injection.
  • Heparin belongs to the class of medicines known as anticoagulants (may also be called a blood thinner).
  • Small doses of Heparin may be used to keep indwelling blood catheters free from coagulated blood.
  • Heparin may make you bruise or bleed more easily. In addition, it may take longer than usual for you to stop bleeding after a cut.

FAQs

Is Heparin addictive?

Yes, though rare but drug addiction was found among people who took Heparin.

Can I have Heparin with alcohol?

No, this may cause stomach bleeding.

Any particular food item to be avoided?

Avoid the intake of food containing vitamin K.

Can I have Heparin when pregnant?

Yes, only if the benefit outweighs the risk.

Can I have Heparin when feeding a baby?

Yes, only if the benefit outweighs the risk.

Can I drive after taking Heparin?

Yes.

What happens if I overdose on Heparin?

Overdosing may lead to nose bleeding, vomiting, blood in urine.

What happens if I eat expired Heparin?

It is advised to not to take expired medicines.

What happens if I miss a dose of Heparin?

Take the next dose at the scheduled time. Never take more than the dose for a missed one.

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