Imipramine: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

0
195
Imipramine: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

What is Imipramine?

Imipramine belongs to group of drugs called as “tricyclic antidepressant” which is primarily used for treatment of depression in adults and nocturnal enuresis (bed wetting) in children. It works by restoring the balance of certain chemicals in brain that help regulate mood. Imipramine is available as film coated tablet for oral administration and should always be administered under medical supervision as it may lead to several adverse effects like mood changes, dizziness, tremors etc.

Composition: Imipramine tablet is available in different strengths – 10mg, 25mg and 50mg
Manufactured by – Generic drug
Prescription– Prescription needed
Form – Film coated tablet
Type of Drug –
Tricyclic Anti-depressant

Read more: Syndopa Plus Composition

Uses of Imipramine

Imipramine is used for the treatment of:

  • Symptoms of depression in adults
  • Childhood Enuresis (night time bed wetting) in children
Read more: Naxdom Uses

How does Imipramine work?

Imipramine works by altering the levels of certain chemical messengers (serotonin and others) in brain that may be unbalanced in people with depression. Restoring the balance of these chemical messengers in the brain improves the mood and relieves the symptoms of depression (mood, sleep, appetite).

Read more: Duolin Price

How to Take Imipramine ?

  • Imipramine medicine is available in film coated tablet form in various strengths (10mg, 25mg and 50mg).
  • When taken in oral form, it is advised to take this medicine with food or immediately after food to prevent any gastric side effect.
  • Swallow the tablet as a whole with fluids. Do not chew, break, or crush the tablet.
  • Never use Imipramine in more than the recommended dose or for longer periods of time without doctor’s consent.
  • To minimise the risk of adverse effects, your doctor might initially start with a low dose and gradually increase your dose.
  • Do not stop treatment with Imipramine suddenly. The dosage should be tapered gradually and then stopped. Stopping the medicine suddenly may lead to withdrawal symptoms.

Common Dosage for Imipramine

The drug dosage is decided by the physician based upon:

  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • For hospitalised patients with depression, the dose is initiated at 100mg/day which can be gradually increased up to 200mg/day. The maximum recommended dose is 250 to 300mg/day.
  • For outpatients, initial recommended dose is 75mg/day which can be increased up to 150mg/day. Dosage over 200mg/day is not recommended.
  • For patients with childhood enuresis, initial oral dose of 25mg/day is administered one hour before bed time. This dose can be increased up to 50-75mg per day at night. Dose of more than 75mg is not recommended as it may increase the incidence of side effects in children.

Q. What happens if I overdose on Imipramine?

Imipramine should not be administered in more than prescribed dose. Taking increased dose will not improve your symptoms earlier; rather it may cause serious side-effects like dizziness, hallucinations, seizures. In case of over dosage, consult your doctor immediately.

Q. What happens if I miss a dose of Imipramine?

The potency of the medicine may decrease because for effective working of the drug, a certain amount of drug must be present in your body at all times. Always consume the missed dose as soon as you remember. But, if it’s already time for the next dose – do not double the dose.

Q. What happens if I eat expired Imipramine?

The medicine may not work as well as the potency of the medicine gets affected. Please inform your physician regarding the same. To be on the safer side, always check and never use an expired medicine.

Q. What is the onset time of Imipramine?

Patients may notice improvement in few weeks following treatment with Imipramine therapy. Even if symptoms disappear, it should be taken until advised as sudden withdrawal can lead to unwanted withdrawal symptoms.

Q. Till when does the effect of Imipramine stay?

The duration of time for which the medicine remains effective varies depending upon the clinical condition.

Read more: Urimax Dosage

When to Avoid Imipramine?

Imipramine should not be used in the following conditions:

  • Allergic to any of its components
  • Patients on MAO inhibitor drugs
  • Patients with hypertension
  • Patients with heart problems
  • People with liver or kidney problem
  • Glaucoma patients
  • Epileptic patients
  • Alcoholic patients
  • Pregnant and lactating mothers

Precautions While Taking Imipramine

Patients with breathing problems, glaucoma, heart problems, liver and kidney disease should use Imipramine with caution and under supervision of a doctor.

Read more: Amixide H Precaution | Panadol Precaution

Side-Effects of Imipramine

Majority of the patients do not show any side effects. Few patients might show side effects which include:

  • Drowsiness (common)
  • Dizziness (common)
  • Nausea (common)
  • Vomiting (common)
  • Dry mouth (less common)
  • Insomnia (less common)
  • Loss of appetite (less common)
  • Tremor (less common)
  • Changes in blood pressure (less common)
  • Anxiety (less common)
  • Low sexual desire (less common)
  • Delayed ejaculation (less common)
  • Blurred vision (vision changes) (less common)
  • Alteration in blood glucose levels (less common)
  • Weight changes (less common)

In addition, it may also cause some allergic or unwanted effects. In such cases, seek medical attention immediately.

Are There Any Reported Allergic Reactions to Imipramine?

Tell your doctor if you are allergic to any of its ingredients.

Signs and symptoms include:

  • Rash (common)
  • Itching (common)
  • Shortness of breath (less common)
  • Swelling of face, lips, tongue, or throat (rare)
  • Loss of consciousness (rare)

 What are the effects of Imipramine on organs?

  • Imipramine should be used cautiously in patients with heart disease. An ECG should be taken prior to large dose administration of Imipramine.
  • Patients with liver and kidney disease should administer Imipramine with caution and under the observation of a doctor.

Drug Interactions to be Careful About

Drug interaction refers to effect of drugs on each other and on human body after ingestion. Large numbers of medicines have shown to interact with each other. Interactions are not just limited to drugs, but certain food items and some laboratory tests which should not be taken right after consuming Imipramine. We explore these in details below.

1. Food Interactions with Imipramine

Avoid eating grape fruit and drinking grape fruit juice as it can slow down the breakdown of Imipramine which causes the drug level to be dangerously high in the blood.

2. Medicines Interactions with Imipramine

It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used.It may interact with the following drugs and products:

  • Alcohol (mild)
  • Cimetidine (moderate)
  • Phenytoin (moderate)
  • Barbiturates (moderate)
  • Digoxin (moderate)
  • MAO inhibitors (severe)
  • Diazepam (severe)
  • Alprazolam (severe)

3. Effects of Imipramine on Lab Tests

No effect on any lab tests noted while taking Imipramine.

4. Interactions with Pre-existing Conditions/Diseases

Patients suffering from pre-existing kidney diseases and cardiac disease must consult their physician before consuming Imipramine.

Q. Can I have Imipramine with alcohol?

Concomitant administration of Imipramine with alcohol increases the risk of side effects like dizziness and drowsiness thus it should be avoided.

Q. Any particular food item to be avoided?

Avoid eating grape fruit and drinking grape fruit juice as it can slow down the breakdown of Imipramine which causes the drug level to be dangerously high in the blood.

Q. Can I have Imipramine when pregnant?

Imipramine should be used with caution in pregnancy as it has shown adverse effects on foetus especially when administered in third trimester. Therefore Imipramine should only be used if the benefits justify the risk to the foetus.

Q. Can I have Imipramine when feeding a baby?

Imipramine should not be used in breastfeeding women as the drug may pass into breast milk and lead to fatal adverse effects in foetus.

Q. Can I drive after taking Imipramine?

Imipramine does affect your ability to drive as it is associated with side effects like drowsiness, headache, dizziness thus it may not be advisable to drive a vehicle and operate heavy machinery while on this medication.


Substitutes of Imipramine

The following are alternative drugs for Imipramine:

  • Depsonil
    • Manufactured by – Abbott Healthcare Pvt Ltd
    • Price – Rs. 9.89
  • Antidep
    • Manufactured by – Torrent pharmaceuticals
  • Depsol
    • Manufactured by – Intas pharmaceuticals
    • Price – Rs. 9.75
Save Using: Myra Medicines Coupons | 1mg Coupons | Practo Coupons

Storage requirements for Imipramine

  • Storage at room temperature away from direct light and heat unless mentioned in the package insert.
  • Keep medicines away from children and pets.

FAQs – 10 Important Questions Answered about Imipramine

Q. What is Imipramine?

Imipramine belongs to group of drugs called as “tricyclic antidepressant” which is primarily used for treatment of depression in adults and nocturnal enuresis (bed wetting) in children. It works by restoring the balance of certain chemicals in brain that help regulate mood. Imipramine is available as film coated tablet for oral administration and should always be administered under medical supervision as it may lead to several adverse effects like mood changes, dizziness, tremors etc.

Q. What are the uses of Imipramine?

It is used for treatment of depression in adults and nocturnal enuresis (bed wetting) in children.

Q. What are the side effects of Imipramine?

Ans. The most common side effects of Imipramine are Drowsiness, Dizziness, Nausea, Vomiting, Dry mouth, Insomnia, Loss of appetite, Tremor, Changes in blood pressure, Anxiety

Q. Should Imipramine be taken on an empty stomach?

Imipramine should be taken after meals as it can lead to gastric side effects when administered empty stomach.

Q. Does Imipramine make you drowsy?

Yes Imipramine may make you feel dizzy and drowsy.

Q. What should be the time gap between the intakes of two Imipramine doses?

There should be a time gap of at least 8-12 hours between two doses of Imipramine.

Q. Should I complete the whole cycle of the medicine even if cured?

A complete course prescribed by your doctor must be taken for complete cessation of symptoms from your body.

Q. Does Imipramine effect my menstrual cycle?

Imipramine may affect menstrual cycle in females.

Q. Is Imipramine safe for children?

Imipramine is safe for consumption in children above 6 years of age. Children below 6 years should use it with caution.

Q. Are there any symptoms that I should consider before taking Imipramine?

Patients with heart disorder should get ECG done before administering large doses of Imipramine.

Q. Is Imipramine legal in India?

Yes, it is legal. 


Similar Reads: 


Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.

LEAVE A REPLY

Please enter your comment!
Please enter your name here

two × 3 =