What is Indomethacin?

  • Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic activity.
  • It is used as a prescription medication to reduce fever, pain, stiffness, and swelling from inflammation.
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Uses of Indomethacin

  • Mild to moderate pain
  • Osteoarthritis
  • Rheumatoid Arthritis
  • Ankylosing Spondylitis
  • Bursitis
  • Tendinitis
  • Acute Gout
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How does Indomethacin work?

Indomethacin works by inhibiting the production of prostaglandins, endogenous signaling molecules known to cause these symptoms. It inhibits the enzyme cyclooxygenase (COX), the enzyme responsible for catalyzes the rate-limiting step in prostaglandin synthesis via the arachidonic acid pathway.

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How to take Indomethacin?

  • Indomethacin is administered orally in the form of tablet, usually 2 to 3 times a day with a full glass of water.
  • Do not lie down for at least 10 minutes after taking this drug.
  • If stomach upset occurs, take it with food, milk, or an antacid.

Common dosage of Indomethacin

  • Recommended dose for adult dosage in case of acute gout is 50 mg orally or rectally 3 times a day.
  • For bursitis, dose of immediate-release capsule is 75 to 150 mg per day in 3 or 4 divided doses. In the form of suppository 50 mg rectally up to 3 times a day is given.
  • For tendonitis, dose of immediate-release capsules is 75 to 150 mg per day in 3 or 4 divided doses.
  • Recommended dosage for pain is 20 mg, 3 times a day or 40 mg, 2 to 3 times a day.
  • For osteoarthritis dose of immediate-release capsules is 25 mg, 2 or 3 times a day. Maximum daily dose should not exceed 200 mg
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When to avoid Indomethacin & Precautions to take?

  • Avoid using Indomethacin if you are allergic to it or any other inactive ingredients present along with it.
  • This medicine is not recommended in patients with the history of asthma, rhinitis, urticaria, gastro-intestinal bleeding and who have undergone heart surgery recently.
  • Indomethacin can cause fatal skin allergies without any warnings.
  • Indomethacin is known to cause kidney injury and impaired liver function. Thus, close monitoring is required.
  • Prolonged us of this medicine can increase the risk of diseases like stroke and heart attack which may be fatal.
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Side Effects of Indomethacin

  • Acid or sour stomach
  • Diarrhea
  • Nausea
  • Vomiting
  • Indigestion
  • Fever with chills
  • Skin rash
  • Dizziness
  • Headache
  • Ringing or buzzing in the ears
  • Constipation
  • Unusual tiredness and weakness
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Effect on organs?

  • Gastrointestinal reactions- Nausea, vomiting, constipation, diarrhea, dyspepsia, upper abdominal pain, abdominal pain or distress, indigestion, heartburn, epigastric pain, gastrointestinal bleeding, gastrointestinal perforation, necrotizing enterocolitis.
  • Hepatic reactions- Jaundice, fatal fulminant hepatitis, liver necrosis, and hepatic failure.
  • Metabolic reactions- Decreased appetite, renal dysfunction.
  • Nervous system reactions- Headache, dizziness, presyncope, somnolence, syncope, intracranial bleeding, fainting.
  • Psychiatric reactions- Depression, listlessness.
  • Cardiovascular reactions- Hot flush, congestive heart failure, hypertension, hypotension, tachycardia, chest pain, arrhythmia, palpitations.
  • Dermatologic reactions- Pruritus, rash, sweating or hyperhidrosis, flushing, urticaria.

Reported allergic reactions?

Allergic reactions may include:

  • Sneezing
  • Runny or stuffy nose
  • Wheezing
  • Trouble breathing
  • Hives
  • Swelling of face, tongue, or throat.

Drug interactions to be careful about?

Following drugs may interact with Indomethacin:

  • Methotrexate
  • Warfarin
  • Corticosteroids
  • Antihypertensive

Shows effects

The effect of this medicine can be observed in 30 minutes after administration and lasts for an average duration of 4 to 6 hours.

Storage Requirements for Indomethacin

  • Keep it in an air-tight container.
  • Keep it away from direct light or moisture.
  • Keep it out of reach of children.

Pro Tips when taking Indomethacin

  • Drink plenty amount of water to minimize the irritation caused in the stomach.
  • Indomethacin is considered as first-line options for mild-to-moderate acute pain because at correct dosages they are effective.
  • Take this medicine with food to reduce stomach-related adverse effects.

FAQs – Things to Know About Indomethacin

Is Indomethacin addictive?


Can I have Indomethacin with alcohol?


Any particular food item to be avoided?


Can I have Indomethacin when pregnant?


Can I have Indomethacin when feeding a baby?


Can I drive after taking Indomethacin?


What happens if I overdose on Indomethacin?

Overdose of Indomethacin may cause vomiting, severe headache, dizziness, confusion, numbness, tingling, or seizure (convulsions).

What happens if I eat expired Indomethacin?

Expired Indomethacin may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use expired drug.

What happens if I miss a dose of Indomethacin?

If you miss a dose of Indomethacin, skip it and continue with your normal schedule. Do not double dose for a missed one.

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