What is Ivermectin?
- Ivermectin belongs to the class, anthelmintic. It is a broad-spectrum anti-parasite drug.
- This drug is used against worms and also for head lice in patients with 6 months of age and older.
- Ivermectin treats strongyloidosis by killing the worms in the intestines and onchocerciasis by killing the developing worms.
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Uses of Ivermectin
Ivermectin is prescribed for:
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How does Ivermectin work?
- Ivermectin binds selectively and with high affinity to glutamate-gated chloride ion channels of the parasite. This binding causes an increase in the permeability of the cell membrane to chloride ions which leads to paralysis and death of the parasite.
- Ivermectin also act as an agonist of the neurotransmitter gamma-aminobutyric acid (GABA), thereby disrupting GABA-mediated CNS neurosynaptic transmission. It may also impair normal intrauterine development of a parasite and may inhibit their release from the uteri of gravid female worms.
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Ivermectin Price In India
|12mg Strip of 2 Tablets||Rs. 71.00|
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How to take Ivermectin?
- Ivermectin is administered orally in the form of tablets with a full glass of water.
- This medicine can be used topically or via injection.
- This medicine is taken on an empty stomach at least an hour before a meal.
Common dosage of Ivermectin
- For river blindness, dosage for adults and teenagers is 150 micrograms per kilogram (kg) of body weight as a single dose. For children, the dose is 150 mcg per kg of body weight as a single dose.
- For Strongyloidiasis, adults and teenagers dose is 200 mcg per kg of body weight as a single dose. For children weighing 15 kg or more, the usual dose is 200 mcg per kg of body weight as a single dose.
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When to avoid Ivermectin & Precautions to take?
- Avoid using Ivermectin if you are allergic to it or any other inactive ingredients present along with it.
- Consumption of alcohol is not recommended while receiving Ivermectin.
- Increased concentration of this medicine and can cause skin rash, headache, dizziness, vomiting, diarrhea, and abdominal pain.
- Patients being treated for onchocerciasis may experience mazzotti reaction which are cutaneous and systemic adverse effect.
- Pretreatment assessment for loiasis is recommended for patients with significant exposure to endemic areas and when treated with Ivermectin for onchocerciasis due to an increased risk of fatal encephalopathy.
- Ivermectin is contraindicated for use in children below 5 years of age with body weight less than 15 kg.
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Side Effects of Ivermectin
- Skin rash
- Muscle pain
- Increased heartbeat
- Swelling of face, hands, lower legs or feet
- Loss of appetite
- Abdominal pain
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Effect on organs?
- Ocular reactions- Eyelid edema, anterior uveitis, blurred vision, conjunctivitis, punctate opacity, and keratitis, abnormal sensation in the eyes, and chorioretinitis or choroiditis worsening of Mazzotti reactions.
- Nervous system reactions- Dizziness, headache, somnolence, vertigo, and tremor.
- Gastrointestinal reactions- Anorexia, constipation, diarrhea, nausea, vomiting, asthenia and abdominal distension.
- Hematologic reactions- Decreased leukocyte count, eosinophilia, and increased hemoglobin.
- Hepatic reactions- Elevated ALT or AST, elevated liver enzymes, elevated bilirubin, and hepatitis.
- Cardiovascular reactions- Tachycardia and orthostatic hypotension, prolonged PR interval, hypotension.
- Dermatologic reactions- Pruritus, rash, and urticaria, toxic epidermal necrolysis and Stevens-Johnson syndrome.
- Respiratory reactions- Worsening bronchial asthma, laryngeal edema, and dyspnea.
- Musculoskeletal reactions- Myalgia.
Reported allergic reactions?
Allergic reactions may include:
- Shortness of breath
- Swelling of face, throat or hands/legs
Drug interactions to be careful about?
- Barbiturates (Phenobarbital, Butalbital)
- Benzodiazepines (Clonazepam, Lorazepam)
- Sodium oxybate (GHB)
- Valproic acid
- The peak effect of Ivermectin for treating onchocerciasis can be observed in 3 to 6 months and for Strongyloidiasis in 3 months and it lasts for an average duration of 2 to 3 days.
Storage Requirements for Ivermectin
- Keep it in an air-tight container.
- Store it at temperature below 30°C.
- Keep it away from direct light or moisture.
- Keep it out of reach of children.
Pro Tips when taking Ivermectin
- This medicine may cause dizziness, thus get up slowly when rising from a sitting or lying position.
- When applying this medicine to the skin, avoid the area around eye.
- Avoid any food with Ivermectin dose as this medicine should be taken on an empty stomach.
FAQs – Things to Know About Ivermectin
Is Ivermectin addictive?
Can I have Ivermectin with alcohol?
Any particular food item to be avoided?
No; not until your doctor tells you otherwise.
Can I have Ivermectin when pregnant?
Yes; if benefit outweigh the risks.
Can I have Ivermectin when feeding a baby?
Can I drive after taking Ivermectin?
What happens if I overdose on Ivermectin?
Overdose of Ivermectin cause numbness, tingling, trouble breathing, loss of coordination, seizures.
What happens if I eat expired Ivermectin?
Expired Ivermectin may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use expired drug.
What happens if I miss a dose of Ivermectin?
If you miss a dose of Ivermectin, skip it and continue with your normal schedule. Do not double dose for a missed one.