What is Lenalidomide?

  • Lenalidomide is an immunomodulatory agent (modifies the function of immune system) used in the treatment of certain cancers
  • It is also used to treat anemia in certain bone marrow disorders like myelodysplastic syndrome
  • It is available in capsule form for oral administration in different strengths: 2.5mg. 5mg, 10mg, 15mg, 20mg, 25mg

Manufactured By – Dabur India Ltd

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Uses of Lenalidomide

It is used to treat:

  • Multiple myeloma
  • Mantle cell Lymphoma
  • Myelodysplastic syndrome (MDS)

How does Lenalidomide work?

  • Lenalidomide has anti-neoplastic activity which works by slowing down or stopping the growth of cancer cells
  • It also inhibits the secretion of pro- inflammatory cytokines (chemical transmitters) and increases the secretion of anti-inflammatory cytokines thus thereby decreasing the inflammation

Lenalidomide Price in India

Specifics Lenalidomide Price
Lenalid 10 mg – 30 Capsules Rs 8976
Lenzest 10 mg – 10 Capsules Rs 2888
Lenangio 10 mg Capsule Rs 2821


How to take Lenalidomide?

  • The drug is rapidly absorbed following oral administration
  • Lenalidomide may be taken either with food or without it
  • Lenalidomide capsule should be swallowed as a whole with water

Common Dosage of Lenalidomide

  • Usual starting dose is 10 mg per day
  • The standard dosage of Lenalidomide is 10-25 mg per day for 21 days of a 28-day cycle(taking medicine for cycle of 21 days then stopping for 7 days)
  • Dose reduction can be done to avoid toxicity in patients especially in patients suffering from kidney disease or immunosuppressed patients

When to avoid Lenalidomide?

  • Avoid taking Lenalidomide if you are allergic to it or any other ingredients present in it
  • Lenalidomide is contraindicated in pregnant and lactating women
  • Avoid Lenalidomide if lactose intolerant
  • Lenalidomide is not recommended, if you have a type of leukemia called chronic lymphocytic leukemia (CLL)
  • Patients with pre-existing liver or kidney disease
  • Use of vaccines with Lenalidomide may either raise the chance of an infection or make the vaccine not work as well

Drug interactions to be careful about

  • Digoxin
  • Warfarin
  • Avoid use of Deferiprone with Lenalidomide. Either increases toxicity of the other
  • Palifermin increases toxicity of Lenalidomide and it is advised to avoid or use alternate drug
  • Avoid co-administration of Vedolizumab with Lenalidomide because of the potential for increased risk of infection
  • Avoid using Dichlorphenamide along with Lenalidomide as they both decrease serum potassium
  • Lenalidomide decreased effects of cholera vaccine which can increase the risk of infection. It is advised to avoid vaccine

Precautions when taking Lenalidomide

  • Because Lenalidomide causes significant neutropenia and thrombocytopenia in almost all patients, patients have to be closely monitored with weekly blood counts and Lenalidomide dose adjusted according to the labeling information
  • Do not donate blood or sperm and do not get pregnant when on Lenalidomide therapy
  • Lenalidomide carries the same risk of teratogenicity as thalidomide, and pregnancy has to be avoided
  • This drug may make you dizzy. Alcohol can make you dizzier. Do not drive or do anything that needs alertness until you can do it safely

Side Effects of Lenalidomide

  • Nausea
  • Vomiting
  • Rashes
  • Alopecia (loss of hair)
  • Epistaxis (nasal bleeding)
  • Upper respiratory tract infections
  • Back pain
  • Diarrhea
  • Headache
  • Dizziness
  • Sweating
  • Nose and throat irritation
  • Constipation
  • Dry mouth
  • Shakiness
  • Weight loss
  • Joint pain
  • Abnormal liver function test
  • Pancytopenia (decrease in WBC, RBC and platelet count)
  • Hallucinations
  • Loss of libido
  • Angina, heart failure
  • Muscle spasm
  • Anxiety

Are There Any Reported Allergic Reactions?

Signs of allergic reactions:

  • Rash
  • Hives
  • Itching
  • Shortness of breath
  • Swelling of face, lips, tongue, or throat

Effect of Lenalidomide on organs

  • Hematological reactions- Anemia, decrease in white blood cells and platelets
  • General reactions- Fatigue, fever, swelling in the extremities, chest pain and tiredness
  • Gastrointestinal reactions- Constipation, diarrhea, nausea, vomiting, abdominal pain and dry mouth
  • Musculoskeletal reactions- Muscle cramps, back pain and bone pain
  • Central Nervous system reactions- Dizziness, tremor, difficulty in swallowing and nerve disease
  • Respiratory reactions- Difficulty in breathing, inflammation of pharynx, upper respiratory tract infection, pneumonia, urinary tract infection and inflammation of sinus
  • Dermatological reactions- Rash, increased sweating, dry skin and itching
  • Metabolic reactions- Loss of appetite, decrease in calcium/potassium, dehydration and decreased weight
  • Eye reactions- Blurred vision
  • Cardiovascular reactions- High or low blood pressure

Shows effects / Results In

Lenalidomide is an immunomodulatory and antiangiogenic drug. It inhibits secretion of pro-inflammatory cytokines and enhances cell-mediated immunity by stimulating proliferation of anti-CD3 stimulated T cells


Storage

  • Keep it away from direct light or moisture
  • Keep it out of reach of children

Pro Tips

  • Avoid donating blood and semen for a month after taking Lenalidomide
  • There is an increased risk of infection, thus be careful around people having infectious disease

FAQs

Is Lenalidomide addictive?

No

Can I have Lenalidomide with alcohol?

No it increases the risk of adverse effects like dizziness.

Any particular food item to be avoided?

Avoid fat containing food.

Can I have Lenalidomide when pregnant?

No it is contraindicated in pregnant women. 

Can I have Lenalidomide when feeding a baby?

No

Can I drive after taking Lenalidomide?

No

What happens if I overdose on Lenalidomide?

Overdosing may cause rash, itching, pruritus or neutropenia.

What happens if I eat expired Lenalidomide?

Expired drug may become ineffective in treating your prescribed conditions, thus to be on the safe side, it is important not to use expired drug.

What happens if I miss a dose of Lenalidomide?

If you miss a dose of Lenalidomide, skip it and continue with your normal schedule. Do not double the dose for a missed one.

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