Linezolid: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

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Linezolid: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

What is Linezolid?

Linezolid belongs to a group of drugs called “antibiotics” and contains Oxazolidinone as its chief ingredient.

Linezolid Composition – Oxazolidinone 400mg / 600mg
Manufactured by – Generic drug
Prescription– Prescription needed
Form – Tablet 
Type of Drug –
Antibiotic


Uses of Linezolid

Linezolid can be used in the prevention, control, and treatment of infections in the lungs, skin, and blood.

Also Read: Emcoril Syrup Uses | Emeset Tablet Uses | Erady Tablet Uses

How does Linezolid work?

  • Linezolid contains Oxazolidinone as its active ingredient.
  • Linezolid inhibits bacterial protein synthesis, thereby inhibiting bacterial growth.

How to Take Linezolid?

  • Linezolid is available in tablet and syrup form for oral use and in parenteral (injection) form.
  • Linezolid is well absorbed orally and can be taken with or without food.
  • The tablet should be swallowed as a whole without crushing, chewing or breaking it along with plenty of fluids.
  • If administered in injection (Intravenous) form, it should be applied by a qualified professional following a test dose to rule out allergy.
  • Parenteral (injection) form should be discontinued as soon as the patient can start oral therapy.

Common Dosage for Linezolid

The drug dosage is decided by the physician based upon:

  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • The recommended dose for Linezolid is – Children – 10 mg/kg every 12 hours, Adults – 600 mg every 12 hours.
  • The duration of treatment for most of the infections is 10-14 days.

Q. What happens if I overdose on Linezolid?

Linezolid should not be administered in more than prescribed dose. Taking increased dose will not improve your symptoms earlier; rather it may cause serious side-effects like constipation. In case of overdosage, consult your doctor immediately.

Q. What happens if I miss a dose of Linezolid?

The potency of the medicine may decrease because, for effective working of the drug, a certain amount of drug must be present in your body at all times. Always consume the missed dose as soon as you remember. But, if it’s already time for the next dose – do not double the dose.

Q. What happens if I eat expired Linezolid?

The medicine may not work as well as the potency of the medicine gets affected. Please inform your physician regarding the same. To be on the safer side, always check and never use an expired medicine.

Q. What is the onset time of Linezolid?

The onset of action of Linezolid starts within 2-3 days following initiation of therapy.

Q. Till when does the effect of Linezolid stay?

The duration of time for which the medicine remains effective is not established.

Read About: Eldervit Dosage

When to avoid Linezolid?

Linezolid should not be used in the following conditions:

  • Allergy – if the patient is allergic to any of the components present in Linezolid.
  • Uncontrolled high blood pressure
  • Pheochromocytoma
  • Thyrotoxicosis
  • Carcinoid syndrome

Precautions While Taking Linezolid

Weekly complete blood counts are necessary while taking Linezolid, particularly in patients consuming the drug for greater than 2 weeks.

Also Know: Dianuron Plus Tablet Precaution

Side-Effects of Linezolid

Majority of the patients do not show any side effects. Few patients might show side effects which include:

  • Diarrhea (most common)
  • Headache (Common)
  • Nausea (Common)
  • Insomnia (Common)
  • Constipation (Common)
  • Rashes (Common)
  • Dizziness (Common)
  • Fever (Common)
  • Lactic acidosis – repeated episodes of nausea and vomiting
  • Serotonin Syndrome – cognitive dysfunction, raise in body temperature, hypermobility of joints and incoordination.
  • Peripheral and optic neuropathy (rare)
  • Convulsions (rare)
  • Superinfections – fungal infections (Less common)
  • Taste alterations (Less common)
  • Itching (Less common)
  • Stomach pain (Less common)
  • Acidity (Less common)
  • Tongue discoloration (Less common)

In addition, it may also cause some allergic or unwanted effects. In such cases, seek medical attention immediately.

Are There Any Reported Allergic Reactions to Linezolid?

Tell your doctor if you are allergic to any of its ingredients.

Signs and symptoms include:

  • Rash (common)
  • Itching (common)
  • Shortness of breath (less common)
  • Swelling of face, lips, tongue, or throat (rare)
  • Loss of consciousness (rare)

What are the effects of Linezolid on organs?

Linezolid should be used cautiously in patients with severe liver and kidney disease. In such cases, dose adjustment as advised by the doctor may also be needed.

Drug Interactions to be Careful About

Drug interaction refers to the effect of drugs on each other and on the human body after ingestion. Large numbers of medicines have shown to interact with each other. Interactions are not just limited to drugs, but certain food items and some laboratory tests which should not be taken right after consuming Linezolid. We explore these in details below.

1. Food Interactions with Linezolid

Food items or beverages containing high tyramine content should be avoided while taking Linezolid. Foods high in tyramine content include –

  • Aged cheeses
  • Fermented or air-dried meats
  • Sauerkraut
  • Soy sauce
  • Tap beers
  • Red wines

You must keep in mind that the tyramine content of any protein-rich food item can increase if stored for a longer time period or if it is not refrigerated properly.  

2. Medicines Interactions with Linezolid

It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used. It may interact with the following drugs and products:

  • Nasal decongestants containing pseudoephedrine (Severe)
  • Adrenergic agents – dopamine and epinephrine (Severe)
  • Serotonergic agents including anti depressants (Severe)
  • Amphotericin B (Moderate)
  • Ceftriaxone (Moderate)
  • Chlorpromazine (Moderate)
  • Diazepam (Moderate)
  • Erythromycin (Moderate)
  • Phenytoin (Moderate)
  • Trimethoprim-sulfamethoxazole (Moderate)

3. Effects of Linezolid on Lab Tests

No effect on any lab tests noted while taking Linezolid.

4. Interactions with Pre-existing Conditions/Diseases

Patients suffering from pre-existing liver and kidney diseases must consult their physician before consuming Linezolid.

Q. Can I have Linezolid with alcohol?

Interaction of Linezolid with alcohol is unknown. Consult your doctor before administration.

Q. Any particular food item to be avoided?

Food items or beverages containing high tyramine content should be avoided while taking Linezolid. Foods high in tyramine content include –

  • Aged cheeses
  • Fermented or air-dried meats
  • Sauerkraut
  • Soy sauce
  • Tap beers
  • Red wines

You must keep in mind that the tyramine content of any protein-rich food item can increase if stored for longer time period or if it is not refrigerated properly.  

Q. Can I have Linezolid when pregnant?

There are no adequate and well-controlled studies in pregnant women.  Always communicate with your doctor if you are pregnant or plan to become pregnant for case-specific recommendations

Q. Can I have Linezolid when feeding a baby?

Nursing mothers are advised to use Linezolid with caution as the drug may pass into breast milk and could harm the baby. Always inform your doctor before if you are breast-feeding your child.

Q. Can I drive after taking Linezolid?

Linezolid usually does not affect your ability to drive. However, If one experiences side effects like drowsiness, headache, dizziness or changes in blood pressure, then it may not be advisable to drive a vehicle and operate heavy machinery while on this medication.

Also Know: Ivoral Tablet Side Effects

Substitutes of Linezolid

The following are alternative drugs for Linezolid:

  • Lizolid
    • Manufactured by – Glenmark Pharmaceuticals
    • Price – Rs. 313.51
  • Linid
    • Manufactured by – Zydus Cadila
    • Price – Rs. 347.31
  • Linox
    • Manufactured by – Torrent Pharmaceuticals
    • Price – Rs. 347.24
  • Linospan
    • Manufactured by – Cipla Ltd.
    • Price – Rs. 347.3
  • Linowin
    • Manufactured by – Hetero Drugs Ltd
    • Price – Rs. 337
  • Xolid
    • Manufactured by – Corona
    • Price – Rs. 201.45

Storage requirements for Linezolid

  • Storage at room temperature away from direct light and heat unless mentioned in the package insert.
  • Keep medicines away from children and pets.
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FAQs – 10 Important Questions Answered about Linezolid

Q. What is Linezolid?

Linezolid belongs to a group of drugs called “antibiotics” and contains Oxazolidinone as its chief ingredient.

Q. What are the uses of Linezolid?

Linezolid can be used in the prevention, control, and treatment of infections in the lungs, skin, and blood.

Q. What are the Side Effects of Linezolid?

The common side-effects of Linezolid are Diarrhea, Headache, Nausea, Insomnia, Constipation, Rashes, Dizziness, and Fever.

Q. Should Linezolid be taken on an empty stomach?

Linezolid can be taken empty stomach.

Q. Does Linezolid make you drowsy?

No. It does not make you drowsy.

Q. What should be the time gap between the intakes of two Linezolid doses?

There should be a time gap of at least 8-12 hours between two doses of Linezolid.

Q. Should I complete the whole cycle of the medicine even if cured?

A complete course prescribed by your doctor must be taken for a complete cessation of symptoms from your body.

Q. Does Linezolid effect my menstrual cycle?

No, Linezolid does not affect your menstrual cycle.

Q. Is Linezolid safe for children?

Linezolid is safe for consumption in children above 12 years of age. Children below 2 years should use it with caution.

Q. Are there any symptoms that I should consider before taking Linezolid?

Patients with a history of allergy to Linezolid and its ingredients should not use it.

Q. Is Linezolid legal in India?

Yes, Linezolid is legal in India.


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Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.

 

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