Itraconazole: Uses, Dosage, Side Effects, Precautions, Price & More

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Itraconazole: Uses, Dosage, Side Effects, Precautions & More

What is ltraconazole?

  • Itraconazole is an anti-fungal medicine which is used to treat a wide variety of fungal infections.
  • It is used for the treatment, control, prevention, & improvement of fungal infections of-
  • Lungs
  • Mouth or throat
  • Toenails
  • Fingernails
Buy & Get Minimum 20% Discount: Medlife | Myra Medicines

How does Itraconazole works?

  • Itraconazole works by stopping the growth of various types of fungi.
  • It prevents the fungi from producing the membranes that surrounds the fungal cells.

Itraconazole Price in India

SpecificsItraconazole Price
100 mg Strip of 4 CapsulesRs 120

How to take Itraconazole?

  • Itraconazole is available in the form of capsules, oral solution and injection.
  • Take this medicine in the dose and duration as advised by your doctor.
  • Swallow it as a whole. Do not chew the capsule.
  • Itraconazole capsule should be taken with complete meals for enhanced absorption.
  • Take Itraconazole 2 hours before or 1 hour after taking antacids as antacids may inhibit the absorption of Itraconazole.
  • Also, take this medication with a cola soft drink if you have decreased or no stomach acid or if you take drugs that decrease stomach acid such as cimetidine, famotidine, nizatidine, ranitidine, pantoprazole or omeprazole.
  • Itraconazole oral solution should be used on an empty stomach, at least one hour before or 2 hours after meal. You should measure the solution with a measuring cup and swish the liquid in your mouth for several seconds before swallowing it.
  • The capsule and solution forms cannot be substituted for one another, and only the Itraconazole solution is effective in treating oral candidiasis.
  • Measure the liquid medicine with the dosing syringe provided.
  • When patient is not in the state of taking it orally then it can be given as injection form.

Common dosage of Itraconazole

  • The drug dosage is decided by the physician based upon:
  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • The recommended dose is 200 to 400mg daily as a single dose or two divided doses.
  • Consult your doctor before administering in children below 12 years of age.
  • Never use more than the recommended dose or for longer periods of time without doctor’s consent.

Also read about other medicine’s Dosage: Intagesic MR Dosage | Ibugesic Plus Dosage


Precautions- When to avoid Itraconazole

Avoid taking Itraconazole if you have these conditions:-

  • Allergy to Itraconazole, or any other anti-fungal medicines.
  • Liver disease
  • Kidney disease
  • Heart disease (heart failure, coronary artery disease , heart valve disease)
  • Lung disease (chronic obstructive pulmonary disease)
  • Decreased or no stomach acid
  • Always inform your doctor if you have cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), or HIV.

Side effects of Itraconazole

All medicines have some side effects. Side effects are possible but do not always occur. Consult your doctor if you feel that you have any of them-

  • Nausea
  • Vomitting
  • Diarrhea
  • Gas in stomach
  • Fever
  • Rash
  • Fatigue, muscle pain, joint pain
  • Swelling
  • Dizziness
  • Nervousness, confusion, depression
  • Blurred vision
  • Riniging sensation in ears
  • Increased blood pressure
  • Hepatitis
  • Congestive heart failure

Reported allergic reactions

  • Itraconazole is not recommended if you are allergic to any active ingredient or constituents of it.
  • Possible allergic reactions reported are-
  • Sever skin rash
  • Tingling in your arms or legs
  • Difficult breathing
  • Swelling of your face, lips, tongue or throat

Effect on organs

  • It can affect your liver so consult your doctor if any of these symptoms appear:-
  • Unusual fatigue
  • Poor apettite
  • Nausea
  • Vomitting
  • Yellowing of eyes
  • Pale stools
  • Dark urine
  • It can also affect your heart. Signs and symptoms of heart failure can appear which includes:-
  • Fatigue
  • Oedema (watery fluid collection in body)
  • Shortness of breath
  • Nausea
  • Abdominal pain
  • Inability to sleep

Drug interactions to be careful about-

  • You must inform your doctor about all the drugs, vitamins or herbal supplements you are taking to manage or protect you from drug interactions.
  • All the possible drug interactions might not be listed here. Few common drugs which interact with Itraconazole include:
  • Calcium channel blockers
  • Antacids
  • Cisapride
  • Anticonvulsants such as Carbamezipine
  • Diazepam, Midazolam
  • Pimozide
  • Quinidine
  • HMG Co-a inhibitors (simvastatin or lovastatin)
  • Warfarin
  • Tolbutamide
  • Glipizide
  • Gliburide
  • Protease inhibitors
  • Tacrolimus
  • Sirolimus
  • Cyclosporine
  • Clarithromycin
  • Erythromycin
  • Indinavir
  • Ritonavir

Show effects/Results in

  • Depends on the condition being treated.
Also Read: Ketoconazole Side Effect | Ketorol DT Side Effect | LCZ Side Effect

Storage requirements for Itraconazole

  • Capsules should be stored at room temperature 15-25 degree Celsius and protected from light and temperature.
  • Oral and injectable solutions should be stored below 25 C but not frozen.

Protips:-

  • Do not stop taking Itraconazole or change the dose of this drug without consulting your doctor.
  • You must immediately inform your doctor if you notice any signs of liver / heart disease.
Other Medicine's: Levolin syrup | i-Pill | Lasix

FAQ

Is it addictive?

  • No habit forming tendencies have been reported with this medicine.

Can i have Itraconazole with alcohol?

  • This drug may make you dizzy and taking alcohol with it can make you dizzier.
  • Alcohol may increase the risk of liver problems.

Any particular food item to be avoided?

Please inform your doctor if you consume grapefruit juice.

Can I have Itraconazole when pregnant?

  • It is not advisable to take Itraconazole when pregnant or planning to become pregnant.
  • Women of child bearing age should start this medicine 2 to 3 days after the start or their periods to make sure they are not pregnant.

Can I have Itraconazole when feeding a baby?

  • Itraconazole is not recommended for lactating woman as it is known to excrete in the breast milk.

Can I drive after taking Itraconazole?

  • This drug may make you dizzy and weak. Double / blurred vision can also occur as a side – effect.
  • Kindly refrain from driving if you suffer from any such side-effects which affects your ability to drive.

What happen if I overdose on Itraconazole?

  • Taking more than prescribed dosage can be harmful and can increase the incidence of side effects
  • In case of over-dosage, consult your doctor immediately.

What happen if I eat expired Itraconazole?

An expired drug might not be as potent in treating your condition. It is advisable to refrain from using expired drug.

What happen if I miss a dose of Itraconazole?

  • You must take the missed dose as soon as you remember it.
  • But, if it is already time to take the second dose after that – do not take double dose.

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