Lyser D Tablet: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

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Lyser D Tablet: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

1What is Lyser D?

Used mainly to prevent or treat signs of inflammation like redness, swelling, pain etc. (back pain, osteoarthritis), toothache and fever. Dry mouth and dizziness are the most commonly seen side effect at high repetitive doses. It should be totally avoided in case of liver, kidney or heart impairment and gastric ulcers.

Lyser D Composition:  Diclofenac 50mg + Serratiopeptidase 10mg
Manufactured By: Comed Chemicals
Prescription: Required as it belongs to Schedule ‘H’ but also available as OTC
Form: Tablet, injections, and gel.
Price: Rs. 186.15 for 15 tablets.
Expiry/Shelf Life:  24 months from the date of manufacturing
Type of Drug: 
NSAID + Analgesic


2Uses of Lyser D

Lyser D is used to prevent or treat the following conditions:

  • Back pain: Used to treat back pain caused by sciatica and arthritis.
  • Ankylosing Spondylitis: Used in cases of ankylosing spondylitis to treat symptoms like pain and stiffness.
  • Frozen Shoulder: Used to treat pain in cases of frozen shoulder
  • Menstrual Pain: Used to treat and manage pain during periods (menstruation pain) and provides relief in menstrual cramps.
  • Dental Pain: Used to treat tooth pain caused by infection and decay of the tooth.
  • Osteoarthritis: Used in cases of Osteoarthritis and provides relief in joint pain and stiff muscles.
  • Rheumatoid Arthritis: Used in cases of rheumatoid arthritis.
  • Fever: Used in cases of mild to moderate fever.
  • Headache: Also used to treat mild to moderate headache.
  • Post Surgical pain: Used to manage post-operative or post-surgical pain.
  • Others: Used to treat mild cases of fever due to its antipyretic property.
  • Bursitis: Used in cases of inflammation of lubricating fluid sacs in joints known as Bursitis.
  • Tendonitis: Used in cases of inflammation of a tendon, example tennis elbow known as tendonitis.
Also Read: Macfast Uses | Livogen Uses | Librax Uses

3 How does Lyser D work?

  • Lyser D contains Diclofenac and Serratiopeptidase as its main active ingredient.
  • Diclofenac is a Nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and other signs of inflammation.
  • It works by inhibiting the COX (Cyclo oxygenase) enzymes which further blocks prostaglandin secretion.
  • Prostaglandins are accountable for producing inflammatory signs and inhibition of prostaglandin aids in providing relief from the symptoms
  • Serratiopeptidase works by breaking down the anomalous proteins at the injury site and promotes healing.

4How to take Lyser D?

  • Lyser D is usually available in the form of tablets and gel.
  • Lyser D Tablet is taken by mouth with a glass of water preferably with or after meals as food helps to prevent any potential gastric irritation the drug might cause when taken empty stomach.
  • Lyser D Tablet should never be chewed or crushed. It should be swallowed as a whole.
  • Lyser D Tablet should be taken with an equal time interval of at least 4-6 hours between two doses if more than one dose a day is prescribed.
  • It is advisable to go through the pack insert properly before consuming the drug to have a better understanding of the drug.

5 Common Dosage for Lyser D

  • Lyser D dosage can be decided by the doctor for every individual as per Age, Weight, Mental status, Allergic history and Health status of the patient.
  • The common Adult dose of Lyser D Tablet is a single tablet once or twice a day with an interval of at least 4-6 hours between two doses.
  • It is not recommended to be administered to children below 12 years of age without pediatric consultation
  • Dose alteration should be avoided without proper medical consultation.

Q. What happens if I overdose on Lyser D?

An overdose of Lyser D can cause undesirable effects like nausea, vomiting, stomach discomfort and lethargy and can also lead to complications in a few cases.
Therefore, strictly adhere to the prescribed dose and seek medical help immediately in case of any symptoms of overdose.

Q. What happens if I miss a dose of Lyser D?

The dose prescribed by the doctor should never be missed and if missed, it should be consumed always as soon as you remember it. But, avoid taking a double dose if it’s already time for the second dose after that as it may lead to an overdose of the drug

Q. What happens if I eat expired Lyser D?

Consuming expired Lyser D tablet might not exhibit desirable effects or any side effects. However, one should abstain from consuming the expired drug.

Q. Onset time of Lyser D and till when does the effect of Lyser D stay?

  • The effect of Lyser D can be seen within 30 minutes of oral administration of the drug.
  • Time is taken by the drug to show the desired effects may vary with every individual patient.
Also Read: Levosulpiride Dosage | Lanol-ER Dosage

6 When to Avoid Lyser D?

Do not Consume Lyser D if:

  • Allergy: In cases of known allergy to Lyser D or any other NSAIDs or any of its constituents.
  • Gastric bleeding: In cases of patients with history of gastric ulcer, bleeding or perforations as it can cause swelling and bleeding of stomach, colon or anus.
  • Asthma: In cases of patients with Asthma.
  • Liver/ Kidney impairment: In cases of patients with liver disease and kidney disease or impairment.

7Precautions While Taking Lyser D

  • Elderly patients: Lyser D or any other NSAID should be used with caution in elderly patients as they are at high risk of serious side effects and fatalities.
  • Liver/ Kidney diseases: Dose alteration may be required by the physician in patients with kidney, heart or liver impairments.
  • GI lesions: Lyser D should be used with extra caution in patients with a history of gastrointestinal lesions.
  • Low doses: Lyser D should always be consumed at the lowest possible effective dose.

Warnings When Taking Lyser D

  • Prolonged use can increase the risk of a heart attack in patients already suffering from heart diseases.
  • There should be the equally spaced time interval between two doses.
  • Consume plenty of fluids to counteract the potentially undesirable effects of the drug.
  • Always consume the tablet with or after meals to prevent any gastric irritation.
  • Do not take two different kinds of pain killer concomitantly.

8 Side-Effects of Lyser D

The side effects associated with Lyser D are:

  • Nausea (common)
  • Vomiting (common)
  • Abdominal pain (less common)
  • Diarrhoea (less common)
  • Dizziness (common)
  • Dry Mouth (common)
  • Dry skin (less common)
  • Indigestion (common)
  • Flatulence (less common)
  • Constipation (less common)
  • Loss of appetite (less common)

Are There Any Reported Allergic Reactions to Lyser D?

  • Lyser D is known to cause an allergic reaction with symptoms like rashes, breathing difficulty, swelling of the face, lip and throat, irregular heartbeat and loss of consciousness.
  • In case of any such signs, immediate medical help should be taken.

What are the effects of Lyser D on organs?

  • Lyser D should be used with caution in patients with liver impairment as it can affect the liver.
  • It can cause stomach bleeding in patients with gastric ulcer.

9Drug Interactions to be Careful About

It is always advisable to be careful of a certain drug to drug or drug to food interactions when consuming Lyser D. Always be aware of the food items, other drugs or lab tests while consuming Lyser D. We explore these n details below.

1. Food Interactions with Lyser D

No particular food item to be avoided.

2. Medicines Interactions with Lyser D

All the potential drug interactions might not be listed here. It is always advisable that the patient must inform the physician about all the drugs/products you use. You must notify the doctor about the herbal products that you are currently consuming. You should never alter the drug regimen without your doctor’s approval.

The common drug interactions have been noticed with the following drugs:

  1. ACE Inhibitors (mild)
  2. Aldosterone antagonists (moderate)
  3. Alendronate (mild)
  4. Amiloride (severe)
  5. Aspirin (severe)
  6. Beta blockers (mild)
  7. Brimonidine (moderate)
  8. Calcineurin inhibitors (mild)
  9. Captopril (mild)
  10. Clopidogrel (mild)
  11. Corticosteroids (moderate)
  12. Cyclosporin (moderate)
  13. Dalteparin (mild)
  14. Diclofenac (moderate)
  15. Enoxaparin (mild)
  16. Fluconazole (moderate)
  17. Heparin (moderate)
  18. Ibuprofen (mild)
  19. Lithium(severe)
  20. Loop diuretics (moderate)
  21. Methotrexate (severe)
  22. Phenindione (moderate)
  23. Potassium (mild)
  24. Prostaglandin analogues (mild)
  25. Rifampicin (mild)
  26. Tacrolimus (moderate)
  27. Thiazide diuretics (moderate)
  28. Triamterene (mild)
  29. Warfarin (moderate)

3. Effects of Lyser D on Lab Tests

Lyser D does affect the serum creatinine level.

4. Lyser D’s interactions with Pre-existing Conditions/Diseases

Any Liver or kidney diseases and gastric ulcer.

Q. Can I have Lyser D with alcohol?

No, it is advisable to avoid alcohol consumption while on Lyser D therapy as it can increase the chances of stomach bleeding. Therefore, the doctor should always be consulted before taking alcohol with Lyser D.

Q. Any particular food item to be avoided?

No particular food item is to be avoided.

Q. Can I have Lyser D when pregnant?

No, it is not safe to consume during pregnancy (especially in the first and third trimester of pregnancy) as it can harm the foetus. Always inform the doctor before taking Lyser D in cases of pregnancy or if you’re planning to conceive.

Q. Can I have Lyser D when feeding a baby?

No, it is not safe to administer Lyser D tablet to Lactating mothers as the secretion of the drug in human milk is not known and the drug should be used only when necessary and with caution after informing the doctor about the case.

Q. Can I drive after taking Lyser D?

Lyser D tablet can cause dizziness or drowsiness in some cases. Therefore, one should avoid driving or operating heavy machinery if drowsiness or dizziness occurs.

Also Read: Mannitol Side Effect | Maxtra Syrup Side Effect | Mebex Side Effect

10 Buyer’s Guide – Lyser D Composition, Variant and Price

Lyser D Variants Lyser D Composition Lyser D Price
Lyser D Nanotech 30gm gel Diclofenac 10mg + Menthol 50mg + Methyl Salicylate 150mg Rs. 107.50 for 1pack
Lyser 10mg Tablet Serratiopeptidase 10mg Rs. 58.50 for 10 tablets
Lyser Forte Tablet Serratiopeptidase 10mg Rs. 102.10 for 10 tablets
Lyser DP Tablet Paracetamol 325mg + Diclofenac 50mg + Serratiopeptidase 10mg Rs. 102.10 for 10 tablets
Lyser AP Tablet Paracetamol 325mg + Aceclofenac 100mg + Serratiopeptidase 15mg Rs. 76.45 for 10 tablets
Buy & Get Minimum 20% Discount: PinHealth | Practo

11Substitutes of Lyser D

The following are alternative drugs for Lyser D:

  • Cipzen D Tablet:
    • Manufactured by – Cipla
    • Price – Rs. 108
  • Diclomol SP Tablet:
    • Manufactured by – Win Medicare
    • Price – Rs. 65
  • Dairo S Tablet:
    • Manufactured by – Icon Lifesciences
    • Price – Rs. 58
  • Biozobid Tablet:
    • Manufactured – by Abbott.
    • Price – Rs. 123.14

 Storage requirements for Lyser D

  • Store the Lyser D tablet at a dry place away from direct heat or sunlight at temperature below 25O
  • Keep it at a place away from children’s reach.

12FAQs – 10 Questions Answered about Lyser D

Q. What is Lyser D?

Ans. Lyser D is a combinational drug that contains Diclofenac and Serratiopeptidase as its main active ingredient.  Lyser D exhibits Nonsteroidal anti-inflammatory drug (NSAID) with analgesic (Pain reliever) and anti-inflammatory properties.

It is used mainly to treat signs of inflammation like redness, swelling, pain, etc. and conditions like the pain of osteoarthritis, toothache, and gout.

Q. How effective it is/ How long does it take for Lyser D to show results?

Ans. The effect of Lyser D can be seen within 30 minutes of oral administration of the drug and the time taken by the drug to show the desired effects may vary with every individual patient.

Q. Should Lyser D be taken on an empty stomach?

Ans.  Lyser D should not be taken empty stomach to prevent any potential stomach upset.

Q. Does Lyser D make you drowsy?

Ans. Yes, Lyser D may cause drowsiness in a few cases but it varies with every individual.

Q. What should be the time gap between the consumption of 2 Lyser D doses?

Ans. The ideal time gap of 4-6 hours should be there between two doses.

Q. Should I complete the whole cycle of the medicine even if cured?

Ans. Lyser D should be consumed as prescribed by the doctor and in case of any severity of symptoms, immediate medical help or consultation should be taken.

And the doctor should be the one to decide when and how to stop the cycle of Lyser D.

Q. Does Lyser D effect my menstrual cycle?

Ans. No, it generally doesn’t affect the menstrual cycle but one should always consult the doctor in case of pre-existing menstrual problems before consuming the drug. Lyser D is, in fact, useful for painful menstruation.

Q. Is Lyser D safe for children?

Ans. Lyser D should not be administered in children without proper consultation and recommendation by the Paediatrician should be taken.

Q. Are there any symptoms that I should consider before taking Lyser D?

Ans. Any liver or kidney disorder or allergic reactions are to be taken into consideration before taking Lyser D.

Q. Is Lyser D legal in India?

Ans. Yes, it is legal in India.


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Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.

13Authored by –

Reviewed and Edited by Dr. Pradeep - Clinical Research Coordinator

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Product Name
Lyser D
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INR 186.15

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