What is Mefloquine?

  • Mefloquine is an anti-malarial medicine used for prevention and treatment of malaria.
  • Mefloquine is available in tablet form for oral administration.
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Uses of Mefloquine:

  • Indicated for treatment of mild to moderate acute malaria caused by Mefloquine susceptible strains
  • Prevention of malaria
Know more: Namenda Uses | Novolog Uses

How does Mefloquine work?

  • The exact mechanism of action of Mefloquine is unknown however it is known that Mefloquine is a blood schizonticide (kills Schizont parasite responsible for causing malaria).

How to Take Mefloquine?

  • Mefloquine can be administered orally along with food or milk. Avoid taking empty stomach to prevent gastric side effects.

Common Dosage for Mefloquine:

  • The recommended dose for treatment of malaria is five 250mg tablets (1250mg) to be given as a single oral dose.
  • If a full course treatment does not lead to any improvement in 48-72 hours, an alternative therapy should be used for treatment.
  • For prophylaxis of malaria, one 250mg tablet should be taken once a week. This should begin 1 week before arrival in an endemic area.
  • To reduce the risk of malaria after leaving an area, prophylaxis must be continued for additional 4 weeks.

When to avoid Mefloquine and precautions to take?

Mefloquine should not be used or should be used with caution when:

  • Allergic to any of its components
  • Patients with active depression
  • Patients with history of convulsions
  • Patients with psychosis and anxiety disorders
  • Patients with liver and kidney disease
  • Pregnant and lactating females
Read more: Vistaril Precaution

Side effects of Mefloquine?

  • Mefloquine may produce multiple side effects, although they may not be common in all the patients. Commonly observed side effects include:
  • Nausea
  • Vomiting
  • Anorexia (loss of appetite)
  • Dizziness
  • Headache
  • Diarrhoea
  • Fatigue
  • Abdominal pain
  • Chills
  • Skin rash
  • Muscle pain
Know more: Zanaflex Side Effects

Effects on organs?

  • Mefloquine has cardiac effects (myocardial depressant) so it should be used with caution in such patients.
  • Mefloquine can lead to liver damage so it should be used with caution in patients already having liver disease.

Reported Allergic Reactions?

  • Tell your doctor if you are allergic to any of its ingredients.
  • Allergy with Mefloquine may exhibit following symptoms:
  • Rash
  • Chest tightness
  • Itching
  • Shortness of breath
  • Swelling of face, lips, tongue, or throat.

Drug Interactions to Be Careful About

  • Consult your doctor before administering any other drugs concomitantly with Mefloquine. All the possible drug interactions might not be listed here. Few important ones include:
  • Quinine
  • Quinidine
  • Calcium channel blocker
  • Tricyclic antidepressants
  • Beta blockers
  • Phenytoin
  • Carbamazepine

Shows Effects / Results In:

  • The time required by Mefloquine to show its desired effect varies from person to person and depends on the clinical situation.

Storage of Mefloquine

  • Storage at room temperature away from direct heat and light.
  • Keep medicines away from children and pets.

Pro Tips When Taking Mefloquine:

  • People with seizure disorder and psychiatric conditions including depression, psychosis, anxiety, and schizophrenia should not take mefloquine.
  • Concomitant administration of Mefloquine along with quinine or quinidine can cause ECG abnormalities and risk of convulsions.

Frequently Asked Questions

Is Mefloquine addictive?

  • No such tendency has been reported.

Can I have Mefloquine with alcohol?

  • Interaction of Mefloquine with alcohol is unknown. But it may increase the incidence of hepatic (liver) damage when administered concomitantly.

Any particular food item to be avoided?

  • No such interaction with food products observed.

Can I have Mefloquine when Pregnant?

  • Mefloquine should be used during pregnancy only if potential benefits justify the potential risk to foetus.

Can I have Mefloquine when feeding a baby?

  • Mefloquine is excreted in breast milk thus it should only be administered in lactating women when it’s clearly needed.

Can I drive after taking Mefloquine?

  • Caution should be exercised as Mefloquine intake is associated with dizziness and loss of balance.

What happens if I overdose on Mefloquine?

  • It should not be administered in more than prescribed dose or frequency.
  • In cases of over dosage, observe the patient and supportive therapy is administered.

What happens if I eat expired Mefloquine?

  • The medicine may not work as well as the potency of the medicines decreases and also it may lead to some adverse effects.

What happens if I miss a dose of Mefloquine?

  • Always consume the missed dose as soon as you remember. But, if it is already time for the next dose – do not double the dose.

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