What is Mefloquine?
- Mefloquine is an anti-malarial medicine used for prevention and treatment of malaria.
- Mefloquine is available in tablet form for oral administration.
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Uses of Mefloquine:
- Indicated for treatment of mild to moderate acute malaria caused by Mefloquine susceptible strains
- Prevention of malaria
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How does Mefloquine work?
- The exact mechanism of action of Mefloquine is unknown however it is known that Mefloquine is a blood schizonticide (kills Schizont parasite responsible for causing malaria).
How to Take Mefloquine?
- Mefloquine can be administered orally along with food or milk. Avoid taking empty stomach to prevent gastric side effects.
Common Dosage for Mefloquine:
- The recommended dose for treatment of malaria is five 250mg tablets (1250mg) to be given as a single oral dose.
- If a full course treatment does not lead to any improvement in 48-72 hours, an alternative therapy should be used for treatment.
- For prophylaxis of malaria, one 250mg tablet should be taken once a week. This should begin 1 week before arrival in an endemic area.
- To reduce the risk of malaria after leaving an area, prophylaxis must be continued for additional 4 weeks.
When to avoid Mefloquine and precautions to take?
Mefloquine should not be used or should be used with caution when:
- Allergic to any of its components
- Patients with active depression
- Patients with history of convulsions
- Patients with psychosis and anxiety disorders
- Patients with liver and kidney disease
- Pregnant and lactating females
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Side effects of Mefloquine?
- Mefloquine may produce multiple side effects, although they may not be common in all the patients. Commonly observed side effects include:
- Anorexia (loss of appetite)
- Abdominal pain
- Skin rash
- Muscle pain
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Effects on organs?
- Mefloquine has cardiac effects (myocardial depressant) so it should be used with caution in such patients.
- Mefloquine can lead to liver damage so it should be used with caution in patients already having liver disease.
Reported Allergic Reactions?
- Tell your doctor if you are allergic to any of its ingredients.
- Allergy with Mefloquine may exhibit following symptoms:
- Chest tightness
- Shortness of breath
- Swelling of face, lips, tongue, or throat.
Drug Interactions to Be Careful About
- Consult your doctor before administering any other drugs concomitantly with Mefloquine. All the possible drug interactions might not be listed here. Few important ones include:
- Calcium channel blocker
- Tricyclic antidepressants
- Beta blockers
Shows Effects / Results In:
- The time required by Mefloquine to show its desired effect varies from person to person and depends on the clinical situation.
Storage of Mefloquine
- Storage at room temperature away from direct heat and light.
- Keep medicines away from children and pets.
Pro Tips When Taking Mefloquine:
- People with seizure disorder and psychiatric conditions including depression, psychosis, anxiety, and schizophrenia should not take mefloquine.
- Concomitant administration of Mefloquine along with quinine or quinidine can cause ECG abnormalities and risk of convulsions.
Frequently Asked Questions
Is Mefloquine addictive?
- No such tendency has been reported.
Can I have Mefloquine with alcohol?
- Interaction of Mefloquine with alcohol is unknown. But it may increase the incidence of hepatic (liver) damage when administered concomitantly.
Any particular food item to be avoided?
- No such interaction with food products observed.
Can I have Mefloquine when Pregnant?
- Mefloquine should be used during pregnancy only if potential benefits justify the potential risk to foetus.
Can I have Mefloquine when feeding a baby?
- Mefloquine is excreted in breast milk thus it should only be administered in lactating women when it’s clearly needed.
Can I drive after taking Mefloquine?
- Caution should be exercised as Mefloquine intake is associated with dizziness and loss of balance.
What happens if I overdose on Mefloquine?
- It should not be administered in more than prescribed dose or frequency.
- In cases of over dosage, observe the patient and supportive therapy is administered.
What happens if I eat expired Mefloquine?
- The medicine may not work as well as the potency of the medicines decreases and also it may lead to some adverse effects.
What happens if I miss a dose of Mefloquine?
- Always consume the missed dose as soon as you remember. But, if it is already time for the next dose – do not double the dose.