What is Methylphenidate?
Methylphenidate is an inhibitor of the dopamine and norepinephrine transporters. It is commonly used to treat ADHD. Methylphenidate is a mild CNS stimulant with more prominent effects on mental than on motor activities. However, large doses produce signs of generalized CNS stimulation that may lead to convulsions.
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Uses of Methylphenidate
- Methylphenidate is used to treat ADHD.
- Methylphenidate is effective in the treatment of narcolepsy and attention-deficit or hyperactivity disorder.
How does Methylphenidate work?
- Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins.
- Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system.
- Alteration of serotonergic pathways via changes in dopamine transport may result.
Methylphenidate Price In India
|10 mg Strip of 10 Tablets||Rs 101.00|
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How to take Methylphenidate?
- The timing of doses is adjusted individually in accordance with the rapidity of onset of effect and duration of action.
- Sustained-release preparations of Methylphenidate may be used once daily in children and adults.
- A transdermal formulation of Methylphenidate is marketed for daytime use.
Common Dosage for Methylphenidate
- Treatment may start with a dose of 5 mg of Methylphenidate in the morning and at lunch
- The dose is increased gradually over a period of weeks depending on the response.
- The total daily dose generally should not exceed 60 mg.
- Because of its short duration of action, most children require two or three doses of Methylphenidate each day.
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When to avoid Methylphenidate?
- The use of Methylphenidate is contraindicated in patients with glaucoma.
- The serum concentration of Methylphenidate can be increased when it is combined with Abiraterone.
- The risk or severity of adverse effects can be increased when Aceprometazine is combined with Methylphenidate.
- Bupropion when combined with other medications that can also cause seizures (Methylphenidate) may increase the risk.
- Methylphenidate may increase the blood levels and effects of Fluoxetine, Lexapro, and Zoloft. This can cause serotonin syndrome, which is a rare effect, causing fever, excessive sweating, blurred vision, muscle spasm, nausea, vomiting, and diarrhea.
- Avoid using MAO inhibitors and blood thinners like warfarin or antidepressants.
Precautions while taking Methylphenidate
- Do not take Methylphenidate if you have ever had an allergic reaction to it or to any of its ingredients.
- Do not consume alcohol; it may increase the effects of Methylphenidate.
- Tell your doctor if you have/ had any heart or psychiatric or liver or kidney disorders.
- Do not freeze Methylphenidate.
- Methylphenidate may be habit-forming.
Side Effects of Methylphenidate
Some commonly reported side effects of Methylphenidate are:
- Abdominal pain
- Weight loss that may be associated with suppression of growth in children
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Effects on organs
- Psychiatric reactions- Psychiatric disorders, insomnia, agitation, depression, nervousness, tension, panic attack.
- Gastrointestinal reactions- dry mouth, nausea, vomiting, abdominal pain, diarrhea, dyspepsia, stomach discomfort.
- Nervous system reactions- headache, dyskinesia, tremor, drowsiness, vertigo, paresthesia, motion sickness.
- Respiratory reactions- Nasopharyngitis, upper respiratory tract infection, cough, pharyngolaryngeal pain, sinusitis, dyspnea.
- Cardiovascular reactions- Palpitations, tachycardia, cardiac disorders, vascular disorders, arrhythmias, hypertension, changes in blood pressure and heart rate.
- Skin reactions- Rash, pruritus, scalp hair loss, dermatitis, skin and subcutaneous tissue disorders.
Storage Requirements for Methylphenidate
- Keep it in a dry, air tight container.
- Keep Methylphenidate away from direct heat or moisture.
- Keep it out of reach of the children.
Pro Tips when taking Methylphenidate
- Generic Methylphenidate is available.
- Methylphenidate should be used in addition to other treatment modalities such as psychotherapy, education, and social integration advice.
- If taking multiple doses of Methylphenidate, ensure that your last dose is taken before 6 pm.
- Avoid alcohol while you are taking Methylphenidate. It may affect Methylphenidate’s absorption.
- Do not get alarmed if you notice something in your stool that looks like a tablet. Some extended-release forms of Methylphenidate do not fully dissolve.
Is Methylphenidate addictive?
Yes, Methylphenidate is addictive
Can I have Methylphenidate with alcohol?
Any particular food item to be avoided?
Try not to consume vitamin C rich food an hour or two, before taking Methylphenidate.
Can I have Methylphenidate when pregnant?
Can I have Methylphenidate while feeding a baby?
Can I drive after taking Methylphenidate?
Yes; if you are sure it won’t affect your driving ability.
What happens if I overdose on Methylphenidate?
Overdosing on Methylphenidate may cause hypertension, tachycardia, delusions, hallucinations, hyperthermia, seizures or death.
What happens if I eat expired Methylphenidate?
Expired medicines may have lost potency and will not be as effective as earlier. Sometimes it can be harmful to the body.
What happens if I miss a dose of Methylphenidate?
Take the missed dose as soon as you remember it. Skip the missed dose, if it’s time for the next dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
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