What is Methylprednisolone?
Methylprednisolone is one of the most commonly used oral steroids. It is a corticosteroid medication. High-dose pulses of intravenous Methylprednisolone sodium succinate (SOLU-MEDROL, others) are used to reverse acute transplant rejection and acute exacerbations of selected auto-immune disorders.
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Uses of Methylprednisolone
Methylprednisolone is used to treat:
- Decrease inflammation
- Suppress immune system
- Skin diseases
- Rheumatic disorders
- Multiple sclerosis
How does Methylprednisolone work?
Methylprednisolone works by decreasing inflammation and changing the body’s immune response. This reduces the inflammation caused by the condition.
How to take Methylprednisolone?
- Take Methylprednisolone by mouth, usually with food or milk.
- Methylprednisolone is also available for intravenous use, but there is no evidence that the high doses previously used (1 g) are more effective.
- Intravenous therapy is usually given until a satisfactory response is obtained, and then oral prednisolone may be substituted.
Methylprednisolone Price In India
|125 mg Vial||Rs 350|
|4 mg Strip of 10 Tablets||Rs 49.61|
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Common Dosage for Methylprednisolone
- Oral prednisolone (40-60 mg) has a similar effect to intravenous hydrocortisone and is easier to administer.
- Short courses of oral steroids (30-40 mg prednisolone daily for 1-2 weeks) are indicated for exacerbations of asthma; the dose may be tapered over 1 week after the exacerbation is resolved (the taper is not strictly necessary after a short course of therapy, but patients find it reassuring).
- Oral steroids are usually given as a single dose in the morning because this coincides with the normal diurnal increase in plasma cortisol and produces less adrenal suppression than if given in divided doses or at night.
- Pulse therapy with higher glucocorticoid doses (e.g., doses as high as 1 to 1.5 g/day of methylprednisolone for 3 days) frequently is used to initiate therapy in patients with fulminant, immunologically related disorders such as acute transplantation rejection, necrotizing glomerulonephritis, and lupus nephritis.
- For acute attacks, pulse glucocorticoids often are employed (typically, 1 g/day of Methylprednisolone administered intravenously for 3-5 days).
When to avoid Methylprednisolone?
- These drugs can cause dangerous effects in the body- live vaccines (nasal flu vaccine, varicella (chickenpox) vaccine, and measles, mumps, and rubella (MMR) vaccine). Don’t receive a live vaccine while taking this drug.
- Taking Methylprednisolone with Cyclosporine raises your risk of side effects from Methylprednisolone because the amount of Methylprednisolone in your body is increased.
- Troleandomycin and ketoconazole if taken with Methylprednisolone require dosage adjustments to keep the body from producing too many steroids.
- Taking Methylprednisolone with aspirin raises your risk of side effects from these drugs.
- Warfarin and heparin when used with Methylprednisolone, make the blood too thin and cause dangerous bleeding.
- When Methylprednisolone is used with Phenobarbital, phenytoin, and rifampin, it may not work as well to treat the condition. This is because the amount of Methylprednisolone in the body may be decreased.
Precautions when taking Methylprednisolone
- Do not take Methylprednisolone if you are allergic to it or any of the ingredients present in it.
- Let your doctor know if you have any heart or kidney problem. Also if you are diabetic let your doctor be aware of that.
- Methylprednisolone can make your immune system weak. Therefore, wash your hands well to prevent the spread of infection.
- Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, and flu).
- Taking Methylprednisolone for a long time may cause brittle bones (osteoporosis).
- If you stop taking the drug suddenly or don’t take it at all symptoms, such as inflammation and pain, may not get better.
Side Effects of Methylprednisolone
Some of the reported side effects of Methylprednisolone are:
- trouble sleeping
- appetite changes
- increased sweating
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Effects on organs?
In general, the most commonly occurring side effects have included:
- fluid retention,
- alteration in glucose tolerance,
- increased blood pressure,
- behavioral and mood changes,
- increased appetite,
- and weight gain.
The incidence generally correlates with dosage, the timing of administration, and duration of treatment.
Storage Requirements for Methylprednisolone
- Keep it in a dry, airtight container.
- Keep it away from direct heat or moisture.
- Keep Methylprednisolone out of reach of the children.
Pro Tips for taking Methylprednisolone
- Used for the palliative care of certain leukemias and lymphomas.
- Prolonged Methylprednisolone use may affect growth and development in children.
- For an evening dose, it is best to take the medicine at least 2 to 3 hours before bedtime.
- Medrol (Methylprednisolone) can increase your appetite, make your body retain more water, and cause changes to your mood.
Is Methylprednisolone addictive?
No, Methylprednisolone is not addictive.
Can I have Methylprednisolone with alcohol?
No, may increase the risk of stomach bleeding.
Any particular food item to be avoided?
Low-sodium, low-salt, potassium-rich, or high-protein diet and grapefruit juice need to be avoided.
Can I have Methylprednisolone when pregnant?
No, not until the benefit outweighs the risk.
Can I have Methylprednisolone while feeding a baby?
No, Methylprednisolone may pass into breast milk and cause side effects in a child who is breastfed.
Can I drive after taking Methylprednisolone?
No, do not drive. Methylprednisolone may make you dizzy.
What happens if I overdose on Methylprednisolone?
Overdose of Methylprednisolone may cause easy bruising, increased acne or facial hair, menstrual problems or loss of interest in sex.
What happens if I eat expired Methylprednisolone?
It is advised to not to take expired medicines.
What happens if I miss a dose of Methylprednisolone?
Take the next dose at the scheduled time. Never take more than the dose for a missed one.
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