What is Metoclopramide?
Metoclopramide is an antiemetic and gastric prokinetic agent. It is particularly useful for nausea secondary to gastroparesis. Metoclopramide is one of the oldest true prokinetic agents; its administration results in coordinated contractions that enhance transit.
Manufactured By – Croford Pharma Pvt Ltd
Other variants and compositions
|Metoclopramide Hcl Injection||Metoclopramide (NA)|
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Uses of Metoclopramide
Metoclopramide (Oral Route) is used to treat:
- Heartburn for patients with gastroesophageal reflux disease
Metoclopramide injection is used as an adjunctive measure in medical or diagnostic procedures such as intestinal intubation or contrast radiography of the GI tract.
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How does Metoclopramide work?
- Metoclopramide works primarily by blocking dopamine receptors found in an area of the brain, chemoreceptor trigger zone.
- Blocking the dopamine receptors in the CTZ prevents nausea messages from being sent to the vomiting center. Thus reducing the sensation of feeling sick and prevents vomiting.
- Metoclopramide (Oral Route) also acts in the upper end of the digestive system, where it enhances the action of a natural chemical, acetylcholine. These actions speed the passage of food through the stomach into the intestine, which physically helps to prevent vomiting.
Metoclopramide Price In India
|HCL Vial of 10 ml Injection||Rs 9.3|
How to take Metoclopramide?
- Metoclopramide is available in oral dosage forms (tablets and solution)
- Also available as parenteral preparation for intravenous or intramuscular use.
- Taking tablets with water is not necessary. Keep it on tongue till it starts dissolving, later swallow it with saliva.
- Take Metoclopramide 30 minutes before eating. Metoclopramide is usually taken before meals and at bedtime.
Common Dosage for Metoclopramide
- The usual initial oral dose range is 10 mg, 30 minutes before each meal and at bedtime. The onset of action is within 30-60 minutes after an oral dose.
- In patients with severe nausea, an initial dose of 10 mg can be given intramuscularly (onset of action 10-15 minutes) or intravenously (onset of action 1-3 minutes).
- Professionally, for prevention of chemotherapy-induced emesis, metoclopramide can be given as an infusion of 1-2 mg/kg administered over at least 15 minutes, beginning 30 minutes before the chemotherapy is begun and repeated as needed every 2 hours for two doses, then every 3 hours for three doses.
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When to avoid Metoclopramide?
- Patients who are using cyclosporine should not take Metoclopramide because this drug can increase blood concentrations and decrease cyclosporine metabolism.
- Combination of tramadol and Metoclopramide can make seizures (side effect) worse.
- Using Metoclopramide together with promethazine can cause Parkinson-like symptoms and abnormal muscle movements. The most serious of the movement disorders medications is a condition known as tardive dyskinesia.
- Narcotic pain medications and diphenhydramine may reduce the effects of metoclopramide.
- Diazepam and Metoclopramide together may increase the risk of impairment in thinking and coordination.
Precautions when taking Metoclopramide
- Do not take Metoclopramide (Oral Route) if you are allergic to it or any of the ingredients present in it.
- Metoclopramide should not be used in patients with bowel obstruction.
- Before taking this medication, tell your doctor if you have any previous history of heart or liver disease or any other health problem.
- Metoclopramide may cause depression in some people; with or without a previous history of it.
- The use of Metoclopramide is contraindicated in patients with pheochromocytoma.
- Metoclopramide should not be used by patients who have seizure disorders. It can increase the severity of seizures.
Side Effects of Metoclopramide (Oral Route)
Metoclopramide may cause:
- Diarrhea, tiredness.
- Extrapyramidal effects.
- Dystonia, usually occurring acutely after intravenous administration.
- Parkinsonian-like symptoms.
- Tardive dyskinesia also can occur with a chronic treatment (months to years).
- Extrapyramidal effects appear to occur more commonly in children and young adults and at higher doses.
- Metoclopramide also can cause galactorrhea by blocking the inhibitory effect of dopamine on prolactin release.
- Methemoglobinemia has been reported occasionally in premature and full-term neonates receiving metoclopramide.
Effects on organs?
- On stomach and intestine- Nausea and bowel disturbances, primarily diarrhea.
- On heart- Hypotension, hypertension, supraventricular tachycardia, bradycardia, fluid retention, acute congestive heart failure and possible AV block.
Storage Requirements for Metoclopramide
- Keep Metoclopramide in a dry, air tight container.
- Keep Metoclopramide away from direct heat or moisture.
- Keep it out of reach of the children.
Pro Tips when Taking Metoclopramide (Oral Route)
- Metoclopramide can be safely stopped when no longer needed.
- When used to treat diabetic gastric stasis, an adjustment may be needed to the dosage of insulin or the timing of the insulin dosage.
- Metoclopramide does not affect the action of birth control pills (oral contraceptive pills).
- You should not take Metoclopramide for more than 12 weeks.
Is Metoclopramide addictive?
No, Metoclopramide is not addictive.
Can I have Metoclopramide (Oral Route) with alcohol?
Drinking alcohol can increase the side effects of sleepiness, dizziness, and confusion from metoclopramide.
Any particular food item to be avoided?
No particular good to be avoided until your doctor advises you so.
Can I have Metoclopramide (Oral Route) when pregnant?
The effects of Metoclopramide are not known yet. Consult your doctor before taking this drug.
Can I have Metoclopramide while feeding a baby?
No, Metoclopramide can pass into breast milk and may harm your baby.
Can I drive after taking Metoclopramide (Oral Route)?
No, Metoclopramide may make you sleep which can put you at risk while driving.
What happens if I overdose on Metoclopramide?
Overdosing on Metoclopramide may cause dizziness, unconsciousness, and seizures.
What happens if I eat expired Metoclopramide?
It is advised to not to take expired medicines.
What happens if I miss a dose of Metoclopramide (Oral Route)?
Take the next dose at the scheduled time. Never take more than the dose for a missed one.
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