Niacin: Uses, Dosage, Price, Side Effects, Precautions & More

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Niacin: Uses, Dosage, Price, Side Effects, Precautions & More

What is Niacin?

Niacin, one of the oldest drugs used to treat dyslipidemia, favorably affects virtually all lipid parameters. Niacin is a water-soluble B-complex vitamin that functions as a vitamin only after its conversion to NAD or NADP, in which it occurs as an amide. Niacin also is the only lipid-lowering drug that reduces Lp(a) levels significantly.

Manufactured By – Nouveau Medicament Pvt Ltd

Other variants and composition – 

Niacin Nf Tablet – Inositol 1000 MG

Buy & Get Minimum 20% Discount: Medlife Online | Myra

Uses of Niacin

  • Nicotinic acid is very effective for increasing HDL and may raise levels by as much as 30%- 35%.
  • Niacin also causes a decrease in LDL.
  • Niacin is also used to treat dyslipidemia.
  • Lowers levels of VLDL (Very-low-density lipoprotein).
  • Raises levels of HDL (high-density lipoprotein).
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How does Niacin work?

  • Nicotinic acid inhibits the hepatic production of VLDL and consequently its metabolite LDL.
  • Nicotinic acid affects HDL metabolism by reducing the transfer of cholesterol from HDL to VLDL and by delaying hepatic HDL clearance.

How to take Niacin?

  • Crystalline Niacin (immediate-release or regular) refers to niacin tablets that dissolve quickly after ingestion.
  • Sustained-release Niacin refers to preparations that continuously release niacin for 6-8 hours after ingestion.
  • Take Niacin with a full glass of cold or cool water.
  • Swallow the tablets.
  • The hypolipidemic effects of Niacin require larger doses than are required for its vitamin effects.

Niacin Price In India

Specifics  Niacin Price
100mg Vial of 1 Injection Rs 17
250mg Vial of 1 Injection Rs 35
500mg Vial of 1 Injection Rs 60
GNC  Niacin:250mg Bottle of 100 Tablets Rs 1239
GNC  Niacin:500mg Bottle of 100 Tablets Rs 1559
Nature’s Bounty Flush Free Niacin Capsules:50 Capsules Rs 2036
Niacin NF:Strip of 10 Tablets Rs 82
Biotrex Niacin:25mg Strip of 60 Capsules Rs 630
Solgar Niacin(Vitamin B3):100mg Bottle of 100 Tablets Rs 1350
Zenith Nutrition Niacin Capsules:Bottle of 100 Capsules Rs 374
Other medicine's Price: Propranolol Price | Ranitidine Price | Ritalin Price

Common Dosage for Niacin

  • The daily dose should not exceed 20 mg.
  • Regular or crystalline Niacin in doses of 2-6 g/day reduces triglycerides by 35-50%; the maximal effect occurs within 4-7 days.
  • Reductions of 25% in LDL-C levels are possible with doses of 4.5-6 g/day, but 3-6 weeks are required for the maximal effect.
  • For lipid-lowering effects, nicotinic acid is given in much higher doses than are needed as a vitamin.
  • Crystalline Niacin tablets are available over the counter (from 50- to 500-mg tablets).
  • To minimize the flushing and pruritus, it is best to start with a low dose (100 mg twice daily taken after breakfast and supper). The dose may be increased stepwise every 7 days by 100-200 mg to a total daily dose of 1.5-2 g.
  • Triple therapy with resins, Niacin, and statins can reduce LDL-C by up to 70%.

When to avoid Niacin?

  • Combination therapy (statin plus niacin or statin plus fibrate) may be required, but caution is necessary with these combinations to avoid myopathy.
  • Severe hepatotoxicity is more likely to occur when patients take more than 2 g of sustained-release, over-the-counter preparations. Affected patients experience flu-like fatigue and weakness.
  • In patients with diabetes mellitus, Niacin should be used cautiously because niacin-induced insulin resistance can cause severe hyperglycemia.
  • Niacin also elevates uric acid levels and may reactivate gout. A history of gout is a relative contraindication for niacin use.

Precautions when taking Niacin?

  • Do not crush, chew, break, or open an extended-release tablet or capsule.
  • Flushing recurs if only one or two doses are missed, and the flushing is more likely to occur when Niacin is consumed with hot beverages (coffee, tea) or with ethanol-containing beverages.
  • Patients with any history of peptic ulcer disease should not take Niacin because it can reactivate ulcer disease.
  • If Niacin is prescribed for patients with known or suspected diabetes, blood glucose levels should be monitored at least weekly until proven to be stable.

Side Effects of Niacin

  • Flushing is the most common side effect and occurs in 80% of patients.
  • Pruritus, paresthesia, and nausea are somewhat less common and occur in about 20% of patients.
  • hyperglycemia, hyperuricemia
  • Flushing and pruritus of the face and upper trunk, skin rashes, and acanthosis nigricans.
  • Atrial tachyarrhythmia and atrial fibrillation have been reported, more commonly in elderly patients.
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Effects on organs?

  • Liver- Niacin can cause chronic liver damage, as shown by elevated liver enzymes, although these drugs very rarely cause liver failure.
  • Skin- Rash, pruritus.
  • Gastrointestinal- Diarrhea, nausea, vomiting.

Storage Requirements for Niacin

  • Keep it in a dry, airtight container.
  • Keep Niacin away from direct heat or moisture.
  • Keep it out of reach of the children.

Pro Tips When Taking Niacin

  • Flushing is worse when therapy is initiated or the dosage is increased but ceases in most patients after 1-2 weeks of a stable dose. Taking an aspirin each day alleviates the flushing in many patients.
  • Dry skin, a frequent complaint, can be dealt with by using skin moisturizers
  • Acanthosis nigricans can be dealt with by using lotions or creams containing salicylic acid.
  • Dyspepsia and rarer episodes of nausea, vomiting, and diarrhea are less likely to occur if the drug is taken after a meal.
  • Side effects tend to be less common with sustained-released formulations.
  • NIASPAN is the only preparation of Niacin that is FDA-approved for treating dyslipidemia and that requires a prescription.
  • Both Niacin and its amide may be given orally as a source of Niacin for its functions as a vitamin, but only Niacin affects lipid levels.

FAQs

Is Niacin addictive?

No, Niacin is not addictive.

Can I have Niacin with alcohol?

No. Drinking alcohol can cause nausea, dizziness, itching, vomiting, upset stomach and flushing.

Any particular food item to be avoided?

Avoid grapefruit juice.

Can I have Niacin when pregnant?

Niacin, at doses used in humans, has been associated with birth defects in experimental animals and should not be taken by pregnant women.

Can I have Niacin while feeding a baby?

Lipid-altering doses of this drug have the potential for serious adverse reactions in nursing infants.

Can I drive after taking Niacin?

No, driving after taking niacin may cause dizziness and blurred vision.

What happens if I overdose on Niacin?

Overdose symptoms may include dizziness, upset stomach, and flushing (warmth, redness, or tingly feeling).

What happens if I eat expired Niacin?

It is advised to not to take expired medicines.

What happens if I miss a dose of Niacin?

Take the next dose at the scheduled time. Never take more than the dose for a missed one.


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