Table of Contents
- 1 What is Nise?
- 2 Uses of Nise
- 3 How does Nise work?
- 4 How to take Nise?
- 5 Common Dosage for Nise
- 6 When to Avoid Nise?
- 7 Precautions While Taking Nise:
- 8 Side-Effects of Nise
- 9 Drug Interactions to be Careful About
- 10 Buyer’s Guide – Nise Composition, Variant and Price
- 11 Substitutes of Nise
- 12 FAQs – 10 Questions Answered about Nise
- 13 Authored by –
What is Nise?
Used broadly to treat various types of pain and fever. Liver toxicity at repetitive high doses is the major side effect. It should be totally avoided in case of liver or kidney impairment and in cases of peptic ulcer also.
Nise Composition: Nimesulide 100mg
Manufactured By: Dr Reddys Laboratories Ltd.
Prescription: Required as it belongs to Schedule H
Form: Tablets, spray and gel
Price: Rs.74 for 15 tablets.
Expiry/Shelf Life: 24 months from the date of manufacturing
Type of Drug: Antipyretic and analgesic
Uses of Nise
Nise serves dual purpose as it works for pain as well as fever
- Muscular Pain: Used to treat muscular pain, and tender joints in case of osteoarthritis & gout.
- Headache: Used as a pain reliever in cases of headache as it has got analgesic property.
- Fever: It is used for fever as it has got nimesulide which is anti-pyretic in nature.
- Bursitis: Used in cases of inflammation of lubricating fluid sacs in joints known as Bursitis.
- Toothache: Used to treat mild to moderate pain in teeth.
- Ankylosing Spondylitis: Used to treat cases of arthritis affecting the spine and joints (ankylosing spondylitis).
- Menstrual Cramps: Used to treat abdominal cramps during menstrual cycle in women.
- Tendonitis: Used in cases of inflammation of tendon, example tennis elbow known as tendonitis.
Also Read: Novamox Uses | Norfloxacin Uses
How does Nise work?
- Nise works by inhibiting the Cyclo-oxygenase (COX) enzymes which further inhibits the production of Prostaglandins which are the reason behind the initiation of pain.
- Prostaglandins are the reason for causing pain, swelling, and redness at the site of injury.
- Therefore, Nise helps to ease the pain, and increases the blood flow across the skin, heat loss and sweating.
How to take Nise?
- Nise is usually available in tablet, spray and gel form.
- Tablets are usually administered through the mouth with water as instructed by the doctor. It should be taken with food or after food, and not with an empty stomach to avoid any adverse effect on the stomach
- The tablet should never be crushed or chewed.
- Before using the Nise gel, always wash and clean the affected area before application.
- Also, wash your hands before and after application of Nise gel on the affected area.
- It is recommended for a patient to go through the leaflet inside the package thoroughly to have a better understanding about the drug.
Common Dosage for Nise
- Nise dosage can be decided by the doctor for every individual as per Age, Weight, Mental status, Allergic history and Health status of the patient.
- Common dose of Nise is decided as per the severity of the pain and at least a gap of 4-6 hours should be there between the two doses.
- Usual recommended Adult dose is 100mg tablet 1-2 times a day with equal time interval or as stated by the doctor.
- Dose alteration as per your own convenience should be avoided
- Not advisable for children below 12 years.
Q. What happens if I overdose on Nise?
The doctor should be consulted immediately in case of Nise overdose, as gastric emptying (gastric lavage) is to be performed as a treatment measure. Symptoms of overdose can be seen as drowsiness, lethargy, stomach discomfort etc.
Q. What happens if I miss a dose of Nise?
The drug may not exhibit proper effects if you miss a dose because, for effective working of the drug, a certain amount of drug must be present in your body at all times. Consume the missed dose always as soon as you remember it. But, do not take a double dose if it’s already time to take the second dose after that as it may lead to overdose of the drug.
Q. What happens if I eat expired Nise?
The expired antibiotic may not work as it might not be potent enough to produce desirable effects. The consulting physician should be informed regarding the same.
Q. Onset time of Nise and till when does the effect of Nise stay?
- Nise Tablets reaches its peak effect or shows result in about 30 minutes after oral administration.
- It is advised to keep 4-6 hours interval between two doses of Nise.
- The time taken by the drug to show its effect may vary with every individual.
Also Read: Ttinjection Dosage | Sumo Dosage | Tryptomer Dosage
When to Avoid Nise?
Do not Consume Nise if:
- Allergy: If there is any known allergy to Nise or its constituents, nimesulide.
- Allergy to aspirin or same class of drugs: If there is any known allergy to Nimesulide or any other Non-Steroidal Anti-Inflammatory Drug (NSAID) like Aspirin, Diclofenac, etc.
- Ulcers: In cases of peptic ulcers as it can lead to stomach, colon and anal bleeding.
- Underage Patients: In cases of children under 12 years of age.
- Liver or Kidney disorders: In patients having liver or severe kidney problems, as it is excreted through kidneys and is metabolized by liver and in cases of kidney or liver problem, it will not be able to get metabolized or excreted properly which can lead to its toxicity.
- Asthma: if one is suffering from asthma or any other breathing problems
- Post surgery patients: In cases of patients undergone bypass surgery.
Precautions While Taking Nise:
- Empty Stomach: Nise should not be taken empty stomach as it can lead to decreased efficacy of drug as well as stomach bleeding at high doses.
- Allergic Reaction: Any allergic reaction should be immediately reported to the doctor.
- Avoid Dose alteration: Drug alteration should be avoided unless stated by the doctor to avoid the overdose of the drug.
- Time Interval: A fixed time gap of atleast 4-6 hours is to be maintained between the two doses to avoid toxicity.
Warnings When Taking Nise
- One should drink an adequate amount of water to reduce the chances of stomach irritation or indigestion by the drug.
- In the case of Nise overdose or toxicity, immediately visit the doctor
- The doctor should always be informed about any history of gastric problems
- Prolonged use of Nise must be avoided as it can lead to increased risk of Gastric bleeding.
- Prolonged use can increase the chances of a heart attack in patients with pre-existing heart diseases.
Side-Effects of Nise
The side effects associated with Nise are:
- Nausea (common)
- Vomiting (common)
- Loss of appetite (common)
- Abdominal pain ( less common)
- Flatulence ( common)
- Constipation (less common)
- Heartburn (less common)
- Diarrhoea (less common)
- Dry mouth (common)
- Skin rash (less common)
- Dry skin (common)
- Headache (less common)
- Dizziness (less common)
Are There Any Reported Allergic Reactions to Nise?
Following possible allergic reactions have been reported for Nise tablets :
- Irregular heartbeats (less common)
- Loss of Consciousness (Rare)
- Difficulty in breathing (Less common)
- Vomiting (less common)
- Rashes and itching on the skin (less common)
- Painful, tender wounds on lips and mouth (less common)
What are the effects of Nise on organs?
- The dose of Nise should be reduced in patients suffering from liver diseases as high dose can increase the chances of further damage to liver or fatal results
- It can cause bleeding in patients with stomach ulcers or can even lead to ulcer formation by prolonged use.
Drug Interactions to be Careful About
It is always advisable to be careful of a certain drug to drug or drug to food interactions when consuming Nise. Always be aware of the food items, other drugs or lab tests while consuming Nise. We explore these n details below.
1. Food Interactions with Nise
No particular food item to be avoided.
2. Medicines Interactions with Nise
All the potential drug interactions might not be listed here. It is always advisable that the patient must inform the physician about of all the drugs/products you use. You must notify the doctor about the herbal products that you are currently consuming. You should never alter the drug regimen without your doctor’s approval.
The common drug interactions have been noticed with the following drugs:
- Anti-convulsants (e.g. valproic acid) (mild)
- Anti-Fungals (e.g. Ketoconazole), (moderate)
- Anti-Tuberculous Drugs (e.g. Isoniazid), (moderate)
- Tacrine, (mild)
- Pemoline, (mild)
- Amiodarone, (mild)
- Methotrexate, (moderate)
- Methyldopa, (mild)
- Amoxicillin/Clavulanic Acid (mild)
- Furosemide (mild)
- Other Nsaids, Including Aspirin (moderate)
- Warfarin (mild)
- Phenytoin (moderate)
- Fenofibrate (mild)
- Salicylic Acid (mild)
- Lithium (moderate)
- Probenecid (mild)
- Cyclosporine (mild)
3. Effects of Nise on Lab Tests
It does not really affect any laboratory tests but it is advisable to consult with your treating physician before any laboratory investigation.
4. Nise’s interactions with Pre-existing Conditions/Diseases
Any Liver disease or gastric bleeding.
Q. Can I have Nise with alcohol?
No, the consulting physician should be informed immediately if any signs are noticed that signifies bleeding in the stomach (dried and coffee coloured blood in cough or stools).
Q. Any particular food item to be avoided?
No particular food item needs to be avoided.
Q. Can I have Nise when pregnant?
Avoid Nise during pregnancy as it can interfere with the delivery of baby and is not safe for the foetus. The doctor should always be notified if you are pregnant or plan to become pregnant
Q. Can I have Nise when feeding a baby?
No, it is not recommended for lactating mothers to consume Nise. The doctor should always be informed if you are breastfeeding your child.
Q. Can I drive after taking Nise?
Yes, one can drive after taking Nise but should avoid driving if any dizziness or drowsiness occurs.
Buyer’s Guide – Nise Composition, Variant and Price
|Nise Variants||Nise Composition||Nise Price|
|Nise 30gm Gel||Nimesulide + Methyl Salicylate + Menthol + Capsaicin||Rs. 90.00 for 1 pack.|
|Nise D 50gm Spray||Nimesulide + Methyl Salicylate + Menthol + Linseed Oil||Rs. 143.00 for 1 pack|
|Nise MDT Tablet||Nimesulide 100 MG||Rs. 50.50 for 10 Tablets.|
|Nise Kid DT Tablet||Nimesulide 50mg||Rs. 21.00 for 10 Tablets.|
|Nise AT 4mg Tablet||Thiocolchicoside 4mg + Aceclofenac 100mg||Rs. 144.00 for 10 Tablets.|
Substitutes of Nise
The following are alternative drugs for Nise:
- Nimegesic IR Tablet:
- Manufactured by – Alembic Pharmaceuticals Ltd.
- Price – Rs. 52.28
- Nimirite 100mg Tablet:
- Manufactured by – MHS Pharmaceuticals.
- Price – Rs. 22.5
- Painfree Tablet:
- Manufactured by – Pranshu Healthcare.
- Price – Rs. 18.75
- Novolid 100mg Tablet:
- Manufactured by – Mico Labs Ltd.
- Price – Rs. 27.75
Storage requirements for Nise
- The drug should be stored in a cool, moisture free place at the temperature below 25o
- Drug should be kept in a place where it is out of the reach of children.
FAQs – 10 Questions Answered about Nise
Q. What is Nise?
Ans. Nise is basically a Non-Steroidal Anti Inflammatory Drug (NSAID), which has nimesulide as its main constituents. It is used mainly to treat pain and reduce the fever and signs of inflammation like redness, swelling etc.
Q. How effective it is/ How long does it take for Nise to show results?
Ans. Nise shows its effect within about 30 minutes after oral administration of the drug.
Q. Should Nise be taken on an empty stomach?
Ans. No, it can lead to gastric bleeding and can even cause stomach upset.
Q. Does Nise make you drowsy?
Ans. Nise may cause drowsiness in a few cases but it varies with every individual.
Q. What should be the time gap between the consumption of 2 Nise doses?
Ans. The ideal time gap of atleast 4-6 hours should be there between two doses to avoid Nise toxicity or overdose.
Q. Should I complete the whole cycle of the medicine even if cured?
Ans. Nise should be consumed as prescribed by the doctor and in case of any severity of symptoms, immediate medical help or consultation should be taken and the doctor should be the one to decide when and how to stop the cycle of Nise.
Q. Does Nise effect my menstrual cycle?
Ans. No, it generally doesn’t affect the menstrual cycle but one should always consult the doctor in case of pre-existing menstrual problems before consuming the drug
Q. Is Nise safe for children?
Ans. Nise is not recommended for children as it is not safe for children.
Q. Are there any symptoms that I should consider before taking Nise?
Ans. Any liver disorder, stomach distress or allergic reactions are to be taken into consideration before taking Nise.
Q. Is Nise legal in India?
Ans. Yes, it is legal in India.
Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.
Authored by –