What Is Norethisterone?

Norethisterone is a synthetic form of progestin and has a similar action to the female hormone, progesterone. It is used to treat menstrual disorders and abnormal vaginal bleeding in women caused due to hormonal imbalances. It is also used for birth control to prevent unwanted pregnancies.

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Uses Of Norethisterone

Norethisterone is used for the treatment of :

  • Endometrial cancer
  • Abnormal uterine bleeding
  • Amenorrhoea
  • Contraception
  • Premenstrual syndrome
  • Breast cancer
Know more: Quinine Uses

How Does Norethisterone Work?

Norethisterone prevents the body from shedding the lining of the womb by artificially maintaining levels of progesterone in the body. Normally, the level of progesterone in your body drops before your period. When it falls below a certain level,the lining of the womb is shed as a menstrual period.

How to Take Norethisterone?

Norethisterone tablets are meant to be taken orally, with or without food.

Common Dosage Of Norethisterone

Common adult dosage of Norethisterone is 2.5 to 10 mg orally once a day for a duration of 5 to 10 days.

When to Avoid Norethisterone& Precautions To Take?

Use with caution in patients with a history of depression.

Use with caution in patients with edema.

Use with caution in patients with renal and hepatic impairments.

Use with extreme caution in patients with diseases like epilepsy, asthma, migraine, heart and blood vessel disorders.

Also read: Cardivas Precaution | Celiprolol Precaution

Side Effects Of Norethisterone

Common side effects include :

  • Irregular menstrual periods
  • Enlargement of breasts
  • Stomach discomfort and pain
  • Weight loss or weight gain
  • Trouble sleeping
  • Acneiform eruptions
  • Facial hair growth
  • Loss of vision or blurred vision
  • Bulging of eyes
  • Migraine like headaches
  • Difficulty in breathing
  • Presence of blood in cough
  • Sharp or crushing pain in chest
  • Dizziness and fainting
  • Weakness in arms, hands, legs or feet
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Yellowing of skin and eyes
  • Depressed mood
  • Difficulty in swallowing
  • Allergic skin reaction
Know more: Thiopentone Sodium Side Effects

Effect on Organs?

The medicine may cause mild to moderate amounts of fluid retention in the body.

The medicine may cause a varying amount of depression in different individuals.

The medicine can cause blurring of vision and other effects on the eye like proptosis, diplopia etc

Use of this medicine can affect the blood glucose levels and hence caution is advised while treating a diabetic patient.

Use of this medicine may cause irregularities in the menstrual cycle.

Reported Allergic Reactions?

Allergic reactions to the drug have been reported. Symptoms include difficulty in breathing, severe skin rashes, headache, dizziness, dry mouth, fever etc. Seek immediate medical attention in such cases.

Drug Interactions to be careful about?

Norethisterone shows interaction with the following drugs :

  • Carbamazepine
  • Clarithromycin
  • Divalproex
  • Mycophenolate Mofetil
  • Phenytoin
  • Tranexamic Acid
  • Insulin
  • Aminophylline
  • Phenobarbital
  • Griseofulvin

Shows Effects/Results In

Onset of action varies from one person to another. It also varies based on the intended use and levels of other sex hormones in the body.

Duration of effect in the body is subject to vary based on the intended use and quantity consumed.

Storage Requirements for Norethisterone

Store at room temperature, away from heat and direct sunlight.

Keep away from reach of children and pets.

Pro Tips When Taking Norethisterone

Prolonged use of this medicine has been associated with increased risk of breast and cervical cancer. It should be administered with caution in patients exposed to the risk factors.

Use of this medicine should stop at least 4 weeks before a planned surgery or prolonged immobilization.

Frequently Asked Questions

Is Norethisterone addictive?


Can I have Norethisterone with alcohol?


Any particular food item to be avoided?


Can I have Norethisterone when pregnant?


Can I have Norethisterone when feeding a baby?


Can I drive after taking Norethisterone?


What happens if I overdose on Norethisterone?

Seek medical attention upon over dosing of medicine.

What happens if I eat expired Norethisterone?

No major side effect is seen upon consumption of a single dose of expired medicine. However, if you notice any severe side effects, immediately inform your doctor.

What happens if I miss a dose of Norethisterone?

Take the missed dose as soon as you remember.

If it’s almost time for your next dose, skip the missed dose

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