Predmet: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

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Predmet: Uses, Dosage, Side Effects, Price, Composition & 20 FAQs

1What is Predmet?

Predmet is a glucocorticoid medicine that is used mainly for allergic, inflammatory and immunological disorders. Predmet contains methylprednisolone as its chief ingredient.

Predmet Composition – Methylprednisolone 4mg/16mg
Manufactured by – Sun Pharma Laboratories Ltd.
Prescription– Prescription is required
Form – Tablets
Price – Rs. 42.5
Type of Drug –Corticosteroid


2Uses of Predmet

Predmet is indicated in the treatment of –

  • Lupus, psoriasis and allergic conditions.
  • Rheumatoid arthritis; juvenile chronic arthritis, polymyalgia rheumatic
  • Duchenne muscular dystrophy (a progressive disease in which the muscles do not function properly)
  • Asthma, severe hypersensitivity reactions
  • Transplant surgeries (for immune suppression)
  • Pemphigus, bullous pemphigoid (immune-mediated skin diseases)
  • Blood disorders like Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
  • Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma.
Read About: Modalert Uses

3 How does Predmet work?

  • Predmet is an effective inhibitor of the early phase of inflammation, as well as of the development of chronic inflammation.
  • Predmet significantly inhibits both the proliferation of mononuclear cells (characteristic of inflammatory cells) and the release of inflammatory products or substances by these cells – thereby exerting immune-suppressive actions.
Also Read: Seroflo CompositionVoriconazole Composition 

4 How to Take Predmet?

  • Predmet is available in the form of oral suspensions and tablets.
  • Predmet tablets and oral suspensions are usually taken by mouth with a glass of water as directed by your doctor.
  • Never crush or chew the Predmet tablets.
  • The tablets should be consumed preferably in the morning unless otherwise advised by your doctor.
  • It should be taken at around the same time every day.
  • Shake the syrup bottle well before using and always use a measuring device to consume the exact dose.

5 Common Dosage for Predmet

  • The drug dosage is decided by the physician based upon:
  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • The lowest dose of Predmet should be sought for each patient.
  • The most common dose of Predmet is 20-40mg daily initially up to 80mg daily, reducing to a maintenance dose of 5-20mg daily.

Q. What happens if I overdose on Predmet?

Predmet should not be administered in more than prescribed dose. Taking increased dose will not improve your symptoms earlier; rather it may cause some side effects. In case of overdosage, consult your doctor immediately.

Q. What happens if I miss a dose of Predmet?

The potency of the medicine may decrease because, for effective working of the drug, a certain amount of drug must be present in your body at all times. Always consume the missed dose as soon as you remember. But, if it’s already time for the next dose – do not double the dose.

Q. What happens if I administer expired Predmet?

The medicine may not work as well as the potency of the medicine gets affected. Please inform your physician regarding the same. To be on the safer side, always check and never use an expired medicine.

Q. What is the onset time of Predmet?

The onset time of Predmet depends upon the route of administration and the severity of the disease.

Q. Till when does the effect of Predmet stay?

The duration of time for which the medicine remains effective is not clinically established.

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6 When to avoid Predmet?

Predmet should not be used in the following conditions:

  • if you are allergic to Predmet or any other constituent present in Predmet
  • Increased blood pressure
  • Thromboembolic disorders.
  • Diabetes mellitus or family history,
  • Osteoporosis,
  • Scleroderma,
  • Myasthenia gravis,
  • Liver, kidney, heart, intestinal, adrenal, or thyroid disease.
  • Hepatitis B
  • Herpes eye infection, chickenpox, shingles or measles.
  • Cataracts; glaucoma
  • Emotional problems, depression, or other types of mental illness;
  • Pheochromocytoma (tumour on a small gland near the kidneys);
  • Ulcers;
  • A blood clot in your legs, lungs, or eyes;
  • Always inform your doctor if you are undergoing
  • surgery, including dental surgery
  • Always inform your doctor if you need to receive any vaccinations.
  • Always inform our doctor if have taken Predmet tablets (or a similar medicine) before and had muscular problems

7Precautions While Taking Predmet

  • Predmet can increase your susceptibility to develop infectious diseases. You must stay away from people who are suffering from infectious diseases.
  • The usage of Predmet should never be stopped abruptly or without medical advice.
  • While using Predmet, additional supplementation doses are necessary during times of stress, such as surgery or infection.
  • Routine laboratory studies (including 2-hour postprandial blood glucose and serum potassium), blood pressure, weight, and chest x-rays should be performed at regular intervals for patients on long-term corticosteroid therapy.
  • Prolonged usage of Predmet can lead to decreased bone mineral density and eye effects. Regular bone mineral density examination and regular eye exams should be encouraged.
  • Monitor growth velocity and development in paediatric patients
  • Always monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing’s syndrome with prolonged usage of Predmet.

8Side-Effects of Predmet

Majority of the patients do not show any side effects. Few patients might show side effects which include:

  • A steroid “withdrawal syndrome,” may occur following abrupt discontinuance of corticosteroids. This syndrome includes symptoms such as loss of appetite, nausea, vomiting, tiredness, headache, fever, joint pain, shedding of skin, muscle pain, and/or weight loss.
  • Prolonged use of Predmet can lead to Cushing’s syndrome. Symptoms include increased blood pressure, increased obesity around the trunk of body and thinning of the limbs, purple striations on skin, facial rounding, facial plethora (inked to increased blood volume or flow), muscle weakness, easy and frequent bruising with thin fragile skin, posterior neck fat deposition, loss of bone density, acne, disturbed menstrual cycle, increased body hair and psychiatric abnormalities.
  • Predmet can elevate levels of blood glucose, deteriorate pre-existing diabetes, and can also decrease the effect of anti-diabetic medicines. It is advisable to monitor blood glucose at regular intervals.
  • Predmet can elevate the risk of infections in the body – including viral, bacterial, fungal, protozoan, or helminthic. It also decreases resistance to infections and canworsen existing infections.
  • Predmet can cause increased blood pressure, increase salt and water retention in the body, and can cause increased excretion of potassium and calcium from the body.
  • Potentially severe psychiatric adverse reactions may occur – aggression, depression, emotional disorder, middle insomnia, mood altered, mood swings, sleep disorder
  • Predmet can decrease bone formation and increase bone resorption both through their effect on calcium regulation
  • Predmet may also cause eye diseases like – cataracts, glaucoma with possible damage to the optic nerves, and may increase the risk of secondary eye infections caused by bacteria, fungi, or viruses.
  • Serious Skin Rashes can occur as side effects to Predmet.
  • Long-term use of Predmet can have negative effects on growth and development in children.

In such cases, seek medical attention immediately.

Are There Any Reported Allergic Reactions to Predmet?

Tell your doctor if you are allergic to any of its ingredients.

Signs and symptoms include:

  • Rash (common)
  • Itching (common)
  • Shortness of breath (less common)
  • Swelling of face, lips, tongue, or throat (rare)
  • Loss of consciousness (rare)

What are the effects of Predmet on organs?

Predmet should be taken only after consultation with your doctor if you suffer from kidney disease. Suitable adjustment of dose and monitoring of kidney functions is mandatory in such cases.

9Drug Interactions to be Careful About

Drug interaction refers to the effect of drugs on each other and on the human body after ingestion. Large numbers of medicines have shown to interact with each other. Interactions are not just limited to drugs, but certain food items and some laboratory tests which should not be taken right after consuming Predmet. We explore these in details below.

1. Food Interactions with Predmet

No interactions observed with any food products.

2. Medicines Interactions with Predmet

It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used. It may interact with the following drugs and products:

  • Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen,
  • Oral contraceptives
  • Antacids – leave at least 2 hours between administration of Deflazacort and antacids.
  • Clarithromycin, rifabutin, rifampicin, amphotericin, ketoconazole, tetracycline, fluconazole
  • Medications for diabetes including insulin,
  • Phenytoin
  • Thyroid medications,
  • Verapamil
  • Medicines to treat high blood pressure or diuretics
  • Medicines to treat epilepsy such as carbamazepine, phenobarbital, other barbiturates, phenytoin, primidone, phenylbutazone
  • Methotrexate (for arthritis, crohn’s disease, psoriasis)
  • Mifepristone (used for abortion)
  • ciclosporin (to prevent organ transplant rejection)
  • Anticoagulant drugs used to thin blood
  • Aminoglutethimide, acetazolomide, carboxolone or salicylates
  • Retinoids (for skin conditions)
  • Carbimazole (for hyperthyroidism)
  • Theophylline (for asthma)

 3. Effects of Predmet on Lab Tests

  • Routine laboratory studies (including 2-hour postprandial blood glucose and serum potassium), blood pressure, weight, and chest x-rays should be performed at regular intervals for patients on long-term corticosteroid therapy.
  • Prolonged usage of Predmet can lead to decreased bone mineral density and eye effects. Regular bone mineral density examination and regular eye exams should be encouraged.
  • Monitor growth velocity and development in pediatric patients
  • Always monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing’s syndrome with prolonged usage of Predmet.

 4. Interactions with Pre-existing Conditions/Diseases

Patients suffering from pre-existing kidney and liver diseases must consult their physician before consuming Predmet.

Q. Can I have Predmet with alcohol?

No.  Predmet may cause excessive drowsiness and calmness with alcohol.

Q. Any particular food item to be avoided?

No alteration in its action seen with any food product.

Q. Can I have Predmet when pregnant?

Always inform your doctor if you are pregnant or plan to become pregnant. Prolonged administration of Predmet during pregnancy can lead to growth retardation of foetus. Predmet should only be prescribed when the benefits to the mother and child outweigh the risks.

Q. Can I have Predmet when feeding a baby?

There is no evidence as of whether ingredients of Predmet are excreted in human breast milk or not thus it should be used with caution in lactating mothers.

Q. Can I drive after taking Predmet?

If one experiences side effects like drowsiness, headache or dizziness then it may not be advisable to drive a vehicle and operate heavy machinery while on this medication.

Know More: Voriconazole Side Effects

10 Predmet – Composition, Variant and Price– Buyer’s Guide

Predmet Variants Predmet Composition Predmet Price
Predmet 4 Tablet Methylprednisolone (4mg)  Rs. 42.5
Predmet 8 Tablet Methylprednisolone (8mg)  Rs. 53.63
Predmet 16 Tablet Methylprednisolone (16mg)  Rs. 93.71
Buy & Get Minimum 30% Discount: 1mg CouponsPracto Coupons | Netmeds Offers

11Substitutes of Predmet

The following brands are available for Predmet:

  • Medrol 4mg tablets
    • Manufactured by – Pfizer Ltd
    • Price – Rs. 49.61
  • Zempred 4 tablets
    • Manufactured by – Sun Pharmaceuticals Industries Ltd
    • Price – Rs. 42.5
  • Depotex 4mg tablets
    • Manufactured by – Zydus Cadila
    • Price – Rs. 53
  • Ivepred tablets
    • Manufactured by – Sun Pharmaceuticals Industries Ltd
    • Price – Rs. 42.5
  • Sterio tablets (4mg)
    • Manufactured by – Lupin Ltd
    • Price – Rs. 47.3
  • MP 4mg tablets
    • Manufactured by – Icon Life Sciences
    • Price – Rs. 50
  • Melsone 4mg tablets
    • Manufactured by – Psychotropics India Ltd
    • Price – Rs.31
  • Mepresso T tablets
    • Manufactured by – Intas Pharmaceuticals Ltd
    • Price – Rs. 34.5
  • Methone 4mg tablets
    • Manufactured by – Icarus Healthcare Pvt Ltd
    • Price – Rs. 45.15
  • Nupred tablets
    • Manufactured by – Nectar Remedies Ltd
    • Price – Rs. 49.78
  • Premisol tablets
    • Manufactured by – Molekule India Pvt Ltd
    • Price – Rs. 40

Storage requirements for Predmet

  • Store at room temperature away from direct light and heat, below 25 degree Celsius.
  • Do not freeze the medicine
  • Discard any unused Predmet Oral Suspension remaining after 1 month of first opening the bottle.
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12FAQs – 10 Important Questions Answered about Predmet

Q. What is Predmet?

Predmet contains methylprednisolone as its chief ingredient. Predmet is a glucocorticoid medicine that is used mainly for allergic, inflammatory and immunological disorders

Q. What are the uses of Predmet?

Predmet is used in the treatment of Lupus, psoriasis, Rheumatoid arthritis, Asthma, severe hypersensitivity reactions, Blood disorders like Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura and allergic conditions.

Q. Should Predmet be taken on an empty stomach?

Predmet should not be taken on an empty stomach.

Q. Does Predmet make you drowsy?

Predmet can cause drowsiness.

Q. What should be the time gap between the intakes of two Predmet doses?

The usual time gap between 2 doses of Predmet tablets should be 10-12 hours.

Q. Should I complete the whole cycle of the medicine even if cured?

A complete course prescribed by your doctor must be taken for the complete cessation of symptoms from your body.

Q. Does Predmet effect my menstrual cycle?

No, Predmet does not affect your menstrual cycle.

Q. Is Predmet safe for children?

Predmet is safe for consumption in children above 12 years of age. Children below 2 years should use it with caution.

Q. Are there any symptoms that I should consider before taking Predmet?

Patients with the history of allergic reaction to any of the ingredients of Predmet should use it with caution.

Q. Is Predmet legal in India?

Yes, Predmet is legal in India.


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 Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.

 

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