What is Prednisolone?
- Prednisolone is a glucocorticoid medicine that is used mainly for allergic, inflammatory and immunological disorders
- It is used for several disorders, including
- Lupus, psoriasis and allergic conditions.
- Rheumatoid arthritis; juvenile chronic arthritis, polymyalgia rheumatic
- Duchenne muscular dystrophy (a progressive disease in which the muscles do not function properly)
- Asthma, severe hypersensitivity reactions
- Transplant surgeries (for immune suppression)
- Pemphigus, bullous pemphigoid (immune-mediated skin diseases)
- Blood disorders like Autoimmune haemolytic anaemia, idiopathic thrombocytopenic purpura
- Acute and lymphatic leukaemia, malignant lymphoma, multiple myeloma
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How does Prednisolone work?
- Prednisolone is an effective inhibitor of the early phase of inflammation, as well as of the development of chronic inflammation.
- Prednisolone significantly inhibits both the proliferation of mononuclear cells (characteristic of inflammatory cells), and the release of inflammatory products or substances by these cells – thereby exerting immune-suppressive actions.
Prednisolone Price In India
|Strip of 100 Tablets||Rs 100|
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How to Take Prednisolone?
- The dosage and duration of this medication should be taken as advised by the doctor.
- The dosage is based on your age, medical condition, and response to therapy.
- Prednisolone comes in the form of tablets and syrups to be taken by mouth.
- The tablets should be consumed preferably in the morning, unless otherwise advised by your doctor.
- It should be taken at around the same time every day.
- Shake the syrup bottle well before using and always use measuring device to consume exact dose.
- Prednisolone is also available in the form of injections which is administered by a healthcare professional.
Common Dosage for Prednisolone?
- Dosage is usually based on your condition
- The recommended dose for adults is:
- 20-40mg daily initially up to 80mg daily, reducing to a maintenance dose of 5-20mg daily.
When to Avoid Prednisolone?
Prednisolone should not be used if you are suffering from:
- An allergy to any of its components
- Increased blood pressure
- Thromboembolic disorders.
- Diabetes mellitus or a family history,
- Myasthenia gravis,
- Liver, kidney, heart, intestinal, adrenal, or thyroid disease.
- Hepatitis B
- Herpes eye infection, chickenpox, shingles or measles.
- Cataracts; glaucoma
- Emotional problems, depression, or other types of mental illness;
- Pheochromocytoma (tumour on a small gland near the kidneys);
- A blood clot in your legs, lungs, or eyes;
- Always inform your doctor if you are undergoing a surgery, including dental surgery
- Always inform your doctor if you need to receive any vaccinations.
- Always inform our doctor if have taken prednisolone tablets (or a similar medicine) before and had muscular problems
Side-effects of Prednisolone?
- A steroid “withdrawal syndrome,” may occur following abrupt discontinuance of corticosteroids. This syndrome includes symptoms such as loss of appetite, nausea, vomiting, tiredness, headache, fever, joint pain, shedding of skin, muscle pain, and/or weight loss.
- Prolonged use of Prednisolone can lead to Cushing’s syndrome. Symptoms include increased blood pressure, increased obesity around the trunk of body and thinning of the limbs, purple striations on skin, facial rounding, facial plethora (inked to increased blood volume or flow), muscle weakness, easy and frequent bruising with thin fragile skin, posterior neck fat deposition, loss of bone density, acne, disturbed menstrual cycle, increased body hair and psychiatric abnormalities.
- Prednisolone can elevate levels of blood glucose, deteriorate pre-existing diabetes, and can also decrease the effect of anti-diabetic medicines. It is advisable to monitor blood glucose at regular intervals.
- Prednisolone can elevate the risk of infections in the body – including viral, bacterial, fungal, protozoan, or helminthic. It also decreases resistance to infections and canworsen existing infections.
- Prednisolone can cause increased blood pressure, increase salt and water retention in the body, and can cause increased excretion of potassium and calcium from the body.
- Potentially severe psychiatric adverse reactions may occur – aggression, depression, emotional disorder, middle insomnia, mood altered, mood swings, sleep disorder
- Prednisolone can decrease bone formation and increase bone resorption both through their effect on calcium regulation
- Prednisolone may also cause eye diseases like – cataracts, glaucoma with possible damage to the optic nerves, and may increase the risk of secondary eye infections caused by bacteria, fungi, or viruses.
- Serious Skin Rashes can occur as side effects to Prednisolone.
- Long-term use of Prednisolone can have negative effects on growth and development in children.
In such cases, seek medical attention immediately.
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What effects does Prednisolone have on organs?
- Liver-dose adjustment is needed in patients suffering from severe liver diseases.
- Kidney -no dose adjustment is needed.
- Consult your doctors if any unwanted symptoms are observed.
Reported Allergic Reactions:
Report to your doctor if you are allergic to any of its ingredients
Rare reports of allergic reactionshave been seen, symptoms include:severe skin rashes, shortness of breath and itching.
Drug Interactions to Be Careful About
- All the possible drug interactions might not be listed here
- Prednisolone may interact with the following drugs and products:
- Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen and naproxen,
- Oral contraceptives
- Antacids – leave at least 2 hours between administration of Deflazacort and antacids.
- Clarithromycin, rifabutin, rifampicin, amphotericin, ketoconazole, tetracycline, fluconazole
- Medications for diabetes including insulin,
- Thyroid medications,
- Medicines to treat high blood pressure or diuretics
- Medicines to treat epilepsy such as carbamazepine, phenobarbital, other barbiturates, phenytoin, primidone, phenylbutazone
- Methotrexate (for arthritis, crohn’s disease, psoriasis)
- Mifepristone (used for abortion)
- ciclosporin (to prevent organ transplant rejection)
- Anticoagulant drugs used to thin blood
- Aminoglutethimide, acetazolomide, carboxolone or salicylates
- Retinoids (for skin conditions)
- Carbimazole (for hyperthyroidism)
- Theophylline (for asthma)
- Always inform the physician of all the drugs/products you use
- Inform about the herbal products that you are consuming
- Do not modify the drug regimen without your doctor’s approval
Shows Effects / Results In:
The time taken for recovery depends on the medical condition being treated.
Complete the dose prescribed by your doctor for complete cessation of symptoms
Do not stop taking the drug without consulting your doctor.
Is Prednisolone Addictive?
No. However self-medication and dependence to these medicines should be avoided.
Can I have Prednisolone with alcohol?
Consumption of alcohol should be avoided while taking Prednisolone.
Any particular food item to be avoided?
Do not eat of grapefruit or drink grapefruit juice while taking Prednisolone.
Can I have Prednisolone When Pregnant?
Inform your doctor if you are pregnant or plan to become pregnant for case specific recommendations.
Prolonged administration of Prednisolone during pregnancy can lead to growth retardation of foetus.
Prednisolone should only be prescribed when the benefits to the mother and child outweigh the risks.
Can I have Prednisolone when feeding a baby?
Doses up to 50 mg/day is very unlikely to cause adverse effects in the infant.
Inform your doctor if you are breast-feeding your child and use the medicine as advised
Can I drive after taking Prednisolone?
Do not drive a vehicle and operate heavy machinery while on this medication if you experience:
Increase in blood pressure
What happens if I overdose on Prednisolone?
Immediately inform your doctor if you happen to over-dose on Prednisolone.
What happens if I take expired Prednisolone?
Taking a single dose may not cause any major adverse effect
The potency of the medicine may get reduced
You must always check and never use an expired drug
What happens if I miss a dose of Prednisolone?
To be effective a certain amount of drug must be in your body at all times
Always consume the missed dose as soon as you remember it
If it’s already time to take the second dose – do not take a double dose
Storage of Prednisolone
Store at room temperature away from direct light and heat, below 25 degree Celsius.
Do not freeze the medicine
Discard any unused Prednisolone Oral Suspension remaining after 1 month of first opening the bottle.
Pro Tips When Taking Prednisolone
- Prednisolonecan increase your susceptibility to develop infectious diseases. You must stay away from people who are suffering from infectious diseases.
- The usage of Prednisolone should never be stopped abruptly or without medical advice.
- While using Prednisolone, additional supplementation doses are necessary during times of stress, such as surgery or infection.
- Routine laboratory studies (including 2-hour postprandial blood glucose and serum potassium), blood pressure, weight, and chest x-rays should be performed at regular intervals for patients on long-term corticosteroid therapy.
- Prolonged usage of Prednisolone can lead to decreased bone mineral density and eye effects. Regular bone mineral density examination and regular eye exams should be encouraged.
- Monitor growth velocity and development in paediatric patients
- Always monitor for hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing’s syndrome with prolonged usage of Prednisolone.
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