What is Pregabalin?

Pregabalin belongs to group of drugs called as “anti-epileptics” which is used for the treatment of neuropathic pain and partial epilepsy in adults. Pregabalin is available in capsule form, extended release tablet form and solution form for topical application. Pregabalin should always be administered under medical supervision as it may lead to several neurologic adverse effects.

Composition: Pregabalin capsule is available in different strengths – 25mg, 50mg, 75mg, 100mg, 150mg, 200mg and 300mg, Pregabalin solution – 20mg/ml
Manufactured by – Generic drug
Prescription– Prescription needed
Form – Capsule, extended release tablet, solution
Type of Drug –

Uses of Pregabalin

Pregabalin can be used in the prevention, control and treatment of following diseases and symptoms:

  • Neuropathic pain in cases of post-herpetic neuralgia/ Shingles (herpes zoster viral infection)
  • Neuropathic pain due to damaged nerves in cases of Diabetic neuropathy
  • Neuropathic pain due to spinal cord injury
  • Fibromyalgia (condition associated with pain all over the body, muscle stiffness and tiredness)
  • Partial onset seizures – Pregabalin is used as an adjuvant to other epileptic drugs

How does Pregabalin work?

  • Pregabalin is an anti-convulsant medicine which works by modulating calcium channel activity of nerve cells which calms the nerve and decreases number of pain signals that are sent by damaged nerve to brain thereby controlling neuropathic pain and seizures.

How to Take Pregabalin ?

  • Pregabalin is available in extended release tablet and capsule form for oral administration and solution form for local application.
  • Pregabalin is well absorbed orally and can be administered with or without food. The capsule should be swallowed as a whole without crushing, chewing or breaking it along with plenty of fluids.
  • Pregabalin is used for long term thus to achieve the best results it should be taken regularly at a fixed time
  • It should not be discontinued suddenly; the dose should be tapered first before stopping completely.
  • Some people may become addictive to Pregabalin thus it should be used as prescribed to lower the risk of addiction.

Common Dosage for Pregabalin

The drug dosage is decided by the physician based upon:

  • Health status/medical condition of the patient
  • Severity of symptoms
  • Reaction to the first dose
  • History of allergy/drug reactions
  • For patients with diabetic neuropathy, Pregabalin can be initiated at 50mg three times a day which can be increased up to 100mg three times a day within one week.
  • For patients with post-herpetic neuralgia, recommended dose is 75-150mg two times a day or 50-100mg three times a day.
  • For adult patients with partial onset seizures, Pregabalin at doses of 150mg to 600mg/day has been shown to be effective. (maximum recommended dose- 600mg/day)
  • Recommended dose for fibromyalgia is 300-450mg/day with dose starting from 75mg twice a day to 225mg twice a day depending upon the clinical condition.

Q. What happens if I overdose on Pregabalin?

Pregabalin should not be administered in more than prescribed dose. Taking increased dose will not improve your symptoms earlier; rather it may cause serious side-effects like dizziness, drowsiness, tremors. In case of over dosage, consult your doctor immediately.

Q. What happens if I miss a dose of Pregabalin?

The potency of the medicine may decrease because for effective working of the drug, a certain amount of drug must be present in your body at all times. Always consume the missed dose as soon as you remember. But, if it’s already time for the next dose – do not double the dose.

Q. What happens if I eat expired Pregabalin?

The medicine may not work as well as the potency of the medicine gets affected. Please inform your physician regarding the same. To be on the safer side, always check and never use an expired medicine.

Q. What is the onset time of Pregabalin?

The onset of action of Pregabalin varies depending upon its uses. It may take several weeks before desired effects are observed.

Q. Till when does the effect of Pregabalin stay?

The duration of time for which the medicine remains effective is 10-12 hours.

When to avoid Pregabalin?

Pregabalin should not be used in the following conditions:

  • Allergy – if the patient is allergic to any of the components present in Pregabalin.
  • Kidney disease – Patients with severe kidney disease or on dialysis must consult the physician before use.
  • Patients with heart disease (heart failure)
  • Patients with a history of substance abuse (alcohol, drugs)

Precautions While Taking Pregabalin

  • Sudden withdrawal of Pregabalin is associated with increased seizures, difficulty in sleeping and headache. Thus the drug dosage should be tapered for a week before stopping it completely.
  • Pregabalin increases the risk of suicidal thoughts and altered behavior. Such patients should be regularly monitored.
Read more: Normaton Precaution | Oxynerve Plus Precaution

Side-Effects of Pregabalin

Majority of the patients do not show any side effects. Few patients might show side effects which include:

  • Drowsiness (common)
  • Dizziness (common)
  • Headache (common)
  • Dry mouth (common)
  • Weight gain (common)
  • Trouble sleeping (less common)
  • Suicidal thoughts (less common)
  • Slurred speech (less common)
  • Loss of coordination (less common)
  • Fatigue (less common)
  • Decreased libido (less common)
  • Blurred vision (rare)
  • Allergic skin reaction (rare)

In addition, it may also cause some allergic or unwanted effects. In such cases, seek medical attention immediately.

Are There Any Reported Allergic Reactions to Pregabalin?

Tell your doctor if you are allergic to any of its ingredients. Signs and symptoms include:

  • Rash (common)
  • Itching (common)
  • Shortness of breath (less common)
  • Swelling of face, lips, tongue, or throat (rare)
  • Loss of consciousness (rare)

 What are the effects of Pregabalin on organs?

Pregabalin should be used cautiously in patients with severe kidney disease. In such cases, dose adjustment as advised by the doctor may also be needed.

Drug Interactions to be Careful About

Drug interaction refers to effect of drugs on each other and on human body after ingestion. Large numbers of medicines have shown to interact with each other. Interactions are not just limited to drugs, but certain food items and some laboratory tests which should not be taken right after consuming Pregabalin. We explore these in details below.

1. Food Interactions with Pregabalin

No interaction observed with any food products.

2. Medicines Interactions with Pregabalin

It is always advised that the patient must inform the physician about all the drugs/over the counter products/vitamin supplements used.It may interact with the following drugs and products:

  • Lorazepam (moderate)
  • Captopril (moderate)
  • Ramipril (moderate)
  • Pioglitazone (moderate)
  • Oxycodone (severe)

3. Effects of Pregabalin on Lab Tests

No effect on any lab tests noted while taking Pregabalin.

4. Interactions with Pre-existing Conditions/Diseases

Patients suffering from pre-existing kidney diseases and heart diseases must consult their physician before consuming Pregabalin.

QCan I have Pregabalin with alcohol?

Concomitant administration of Pregabalin with alcohol increases the risk of side effects like dizziness and drowsiness thus it should be avoided.

Q. Any particular food item to be avoided?

No alteration in its action seen with any food product.

Q. Can I have Pregabalin when pregnant?

There are no adequate and well controlled studies for use of Pregabalin in pregnant women, thus it should only be used when benefits outweigh the risks involved. Always communicate with your doctor if you are pregnant or plan to become pregnant for case specific recommendations.

Q. Can I have Pregabalin when feeding a baby?

Nursing mothers are advised to use Pregabalin with caution as the drug may pass into breast milk and could harm the baby. Always inform your doctor before if you are breast-feeding your child.

Q. Can I drive after taking Pregabalin?

Pregabalin does affect your ability to drive as it is associated with side effects like drowsiness, headache, dizziness and suicidal tendencies then it may not be advisable to drive a vehicle and operate heavy machinery while on this medication.

Read more: Onestone Side Effects

Substitutes of Pregabalin

The following are alternative drugs for Pregabalin:

  • Lyrica
    • Manufactured by – Pfizer Ltd
    • Price – Rs. 884.1
  • Pregalin
    • Manufactured by – Torrent pharmaceutical
    • Price – Rs. 210.1
  • Pregaba
    • Manufactured by – Unichem Laboratories
    • Price – Rs. 203.53
  • Neugaba
    • Manufactured by – Sun Pharma
    • Price – Rs. 140
Save Using:  Netmeds Promo Code | Medlife Promo Code |  Pharmeasy Promo Code

Storage requirements for Pregabalin

  • Storage at room temperature away from direct light and heat unless mentioned in the package insert.
  • Keep medicines away from children and pets.

FAQs – 10 Important Questions Answered about Pregabalin

Q. What is Pregabalin?

Ans. Pregabalin belongs to group of drugs called as “anti-epileptics” which is used for the treatment of neuropathic pain and partial epilepsy in adults. Pregabalin is available in capsule form, extended release tablet form and solution form for topical application. Pregabalin should always be administered under medical supervision as it may lead to several neurologic adverse effects.

Q. What are the uses of Pregabalin?

Ans. It is is used for the treatment of neuropathic pain and partial epilepsy in adults

Q. What are the side effects of Pregabalin?

Ans. The most common side effects of Pregabalin are drowziness, Dry mouth , Weight gain, Trouble sleeping. Pregabalin should always be administered under medical supervision as it may lead to several neurologic adverse effects.

Q. Should Pregabalin be taken on an empty stomach?

Pregabalin can be taken empty stomach or after meals.

Q. Does Pregabalin make you drowsy?

Yes Pregabalin may make you feel dizzy and drowsy.

Q. What should be the time gap between the intakes of two Pregabalin doses?

There should be a time gap of at least 8-12 hours between two doses of Pregabalin.

Q. Should I complete the whole cycle of the medicine even if cured?

A complete course prescribed by your doctor must be taken for complete cessation of symptoms from your body.

Q. Does Pregabalin effect my menstrual cycle?

No, Pregabalin does not affect your menstrual cycle.

Q. Is Pregabalin safe for children?

Pregabalin is safe for consumption in children above 12 years of age. Children below 12 years should use it with caution.

Q. Are there any symptoms that I should consider before taking Pregabalin?

Patients with renal impairment or patients undergoing haemodialysis, dose adjustment is necessary.

Q. Is Pregabalin legal in India?

Yes, it is legal.

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Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.

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