Propofol: Uses, Dosage, Price, Side Effects, Precautions & More

What is Propofol?

Propofol is an anesthetic medication which is given to induce and maintain a loss of consciousness.

Manufactured By – Neon Laboratories Ltd

Other variants and composition – 

Propozol Dsr Capsule – Pantoprazole 40 MG, Domperidone 30 MG

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Uses of Propofol

Propofol is used for:

  • Producing loss of consciousness before surgery
  • Maintaining consciousness loss during surgery
  • Sedating adult patients on ventilator
  • General anesthesia
  • Cardiac anesthesia
  • Neurosurgical anesthesia
Also Read: Prochlorperazine Uses | Propranolol Hydrochloride Uses

How Does Propofol Work?

Propofol slows the activity of your nervous system and brain. It acts by inducing and maintaining loss of consciousness before and during surgery. This effect helps you to undergo surgery without pain and complications.

How to Take Propofol?

Propofol is an injection which will be given to you by a doctor or a nurse. They will inject this medication into your blood vessels.

Propofol Price In India

SpecificsPropofol Price
20ml Vial of 1% InjectionRs 275.00
Also Read: Permethrin Price

Common Dosage for Propofol?

The most commonly prescribed dose is between 0.5 mg/kg to 1.5 mg/kg intravenously. Your doctor will give you Propofol in an increment of 20 mg every 10 seconds until you have attained consciousness loss. Your doctor may alter your dosage and its frequency depending upon the severity of your condition.

When to Avoid Propofol?

Your healthcare must not give you Propofol if:

  • You are allergic to any component of Propofol
  • You have microbial contamination
  • You have asthma
  • You have Hypersensitivity
  • You have low blood pressure

Side-Effects of Propofol

Some of the reported side effects of Propofol are:

  • Nausea
  • Vomiting
  • Headache
  • Local site pain
  • Temporary cessation of breathing
  • Slow heart rate
  • Decreased blood pressure
  • Light-headed feeling
  • Shallow breathing
  • Fever
  • Body pain
Also Read: Magnesium Sulphate Side Effect 

Effects of Propofol on Organs?

Use of Propofol is not safe for the patients with kidney and liver disease. Your doctor may adjust your dose as per your requirement.

Are There Any Reported Allergic Reactions?

Some of the common allergic reactions reported with Propofol are hives, difficulty breathing, and swelling of your face, lips, tongue, or throat.

Drug Interactions to Be Careful About

One needs to be careful about the following drug interactions when consuming Propofol:

  • Anesthetics like enflurane, isoflurane, and halothane
  • Narcotic drugs
  • Doxylamine
  • Clonazepam
  • Sodium oxybate
  • Alprazolam
  • Diazepam
  • Antidepressants
  • Pentobarbital
  • Sleeping pills

Effects/Results After Consuming Propofol

The effect of Propofol can be observed within 1 minute of administration. The average duration of action of this medication is between 5 to 10 minutes.

Things to Know About Propofol


Is Propofol addictive?

Propofol does not cause addiction.

Can I have Propofol with alcohol?

It is better to avoid alcohol when on Propofol. Consult your doctor about limiting alcohol with this medication. Co-consumption of alcohol with Propofol causes excessive sleepiness, drowsiness and can even result in very serious adverse events.

Any particular food item to be avoided?

You must consult your doctor regarding the foods to be avoided.

Can I have Propofol when pregnant?

In most cases, it is not safe to take Propofol if you are pregnant or planning a pregnancy. Consult your doctor if it is absolutely necessary to take this medication.

Can I have Propofol when feeding a baby?

Propofol is known to pass in mother’s milk to the baby. Consult your doctor if it is absolutely necessary to take this medication while you are breastfeeding.

Can I drive after taking Propofol?

Propofol is known to cause drowsiness, dizziness, and headache besides altered consciousness. Hence it wise not to drive at least for a day after using Propofol.

What happens if I overdose on Propofol?

Propofol is given to you by a health care provider or a nurse, so the chances of overdose are very less.

What happens if I use expired propofol?

Propofol is given to you by a health care provider or a nurse, so the chances of expired drug administration are very less.

What happens if I miss a dose of Propofol?

Propofol is given to you by a health care provider or a nurse, so the chances of missed dose are very less.

Storage Requirements

  • Always store Propofol in a refrigerator
  • Do not store Propofol in freezer
  • Store it where your children and pets can’t reach

Pro Tips When Taking Propofol

  • Do not try to self-inject Propofol.
  • Do not share your medication with anyone even if they have a similar condition.
  • Discuss the pros and cons of Propofol if you are pregnant or planning a pregnancy or if you are breastfeeding.
  • Share your medical history with your doctor before the administration of Propofol.
Also read about other medicine's: Pheniramine Maleate | Phenobarbital
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