What is Propranolol?

Propranolol is a first generation non-selective -receptor antagonists. It is a competitive receptor antagonist and remains the prototype to which other antagonists are compared. Propranolol has equal affinity for 1 and 2 adrenergic receptors; thus, it is a non-selective adrenergic receptor antagonist.

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Uses of Propranolol?

Propranolol is used to treat:

  • Anxiety
  • muscle tremors
  • hyperthyroidism
  • high blood pressure
  • irregular heart rate
  • myocardial infarction
  • glaucoma
  • prevents a migraine
Also Read: Ranitidine Uses 

How does Propranolol work?

  • Propranolol works by blocking – adrenergic receptors.
  • It crosses the blood-brain barrier and is a lipid soluble and also has sodium channel blocking effects.
  • It blocks the action of epinephrine (adrenaline) and norepinephrine (noradrenaline) at both 1- and 2-adrenergic receptors.

How to take Propranolol?

  • Propranolol is taken by mouth or by injection into a vein (IV).
  • Try to take your doses at the same times each day.
  • Propranolol capsules should be swallowed whole with a drink of water and not be chewed or crushed.

Propranolol Price In India

SpecificsPropranolol Price
Strip of 10*10 CapsulesRs 360

Common Dosage for Propranolol

  • The usual dose is 80-60 mg per day.
  • In the case of Propranolol tablets or liquid, you may need to take a dose two, three or four times a day.
  • In the case of hypertension and migraine, it is 80-240 mg per day twice.
Other medicine's Dosage: Metoprolol Dosage | Naproxen Dosage | Niacin Dosage

When to avoid Propranolol?

  • Drugs such as phenytoin, rifampin, and phenobarbital, as well as smoking, induce hepatic biotransformation enzymes and may decrease plasma concentrations of Propranolol.
  • Cholestyramine and colestipol bind and interfere with the absorption of Propranolol.
  • If you take ergotamine or methysergide to treat a migraine while you’re taking Propranolol, you might feel cold or get numb or tingling hands.
  • The use of beta-blockers is contraindicated in patients with hypotension or cardiogenic because it can depress cardiac output and blood pressure, which can be detrimental.

Precautions when taking Propranolol

  • People who are allergic to Propranolol and to its ingredients should not take this medicine.
  • Before taking the medicine, let your doctor know about any previous or current heart disease you have.
  • Propranolol can exacerbate vasospasm in Prinzmetal angina.
  • Stopping Propranolol can suddenly worsen angina in case of patients with coronary artery disease and it can cause heart attacks. Its dosage should be lowered gradually over several weeks, only if it is necessary to discontinue propranolol.

Side Effects of Propranolol

Some reported side effects of Propranolol are:

  • Nausea
  • Abdominal pain
  • Constipation
  • Insomnia
  • Fatigue
  • Diarrhea
  • Memory loss
  • Shortness of breath
  • Slow heart beat
  • Low blood pressure

Effects on organs?

  • Cardiovascular- Hypotension, cold extremities, Raynaud’s phenomenon.
  • Nervous system- Fatigue, sleep disturbances, nightmares, sleep disorder, agitation, somnolence, irritability.

Storage Requirements for Propranolol

  • Keep it in a dry, air tight container.
  • Keep Propranolol away from direct heat or moisture.
  • Keep it out of reach of the children.

Pro Tips When Taking Propranolol

  • You should take Propranolol at the same time each day, preferably with or immediately following meals.
  • Propranolol is used with caution in patients with asthma and chronic obstructive pulmonary disease due to inhibition of bronchodilation.
  • If you’re taking Propranolol to control the symptoms of an overactive thyroid gland you’ll be able to stop taking it once your thyroid condition is controlled.


Is Propranolol addictive?

No, but taking Propranolol for a longer period may cause withdrawal syndrome.

Can I have Propranolol with alcohol?

No, mixing it together can make you sleepy and unsteady on your feet and may also make your symptoms worse.

Any particular food item to be avoided?

A change in your diet maybe necessary. Consult your doctor.

Can I have Propranolol when pregnant?

No, may lead to harmful effects in the baby.

Can I have Propranolol when feeding a baby?

Yes. But the baby needs to be monitored regularly.

Can I drive after taking Propranolol?

No, for the first few days it is best advised to see the effects of Propranolol as it may make you feel tired or sleepy or faint.

What happens if I overdose on Propranolol?

Overdosing on Propranolol may cause seizures and cardiac arrest.

What happens if I eat expired Propranolol?

It is advised to not to take expired medicines.

What happens if I miss a dose of Propranolol?

Take the next dose at the scheduled time. Never take more than the dose for a missed one.

Also read about other medicine's: Plavix 

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