Razo D Capsule: Uses, Dosage, Side Effects & Price

July 10, 2018

What is Razo D?

Razo d is predominantly used to prevent or treat acidity, heartburn, nausea, and vomiting. Dry mouth and Dizziness are the side effects at repetitive high doses Razo. It should be totally avoided in case of obstructive intestinal diseases and in patients with an allergic history.

Razo D Composition: Rabeprazole 20mg + Domperidone 30mg
Manufactured by: Dr Reddy’s Laboratory.
Prescription: To be sold by prescription but it is also available as OTC (Over the counter)
Form: Capsules and Injections
Price: Rs 224.5 for 15 Capsules.
Expiry/Shelf Life: 24 months from the date of manufacturing
Type of Drug: Antiemetic and Antacid

Uses of Razo D

Razo D serves a dual purpose as it works for pain as well as fever. It is prescribed for the following:

Gastro esophageal Reflex Disease (GERD): Used in cases of GERD as it prevents the acidic content of the stomach from regurgitating backwards into the esophagus.
Motion sickness: Used in cases of Motion sickness as it contains Domperidone that acts as an antiemetic and controls the vomiting centre in the brain.
Gastric Ulcer: Used to treat gastric ulcer.
Nausea & Vomiting: Used to prevent or treat Nausea and vomiting as it contains Domperidone.
Heartburn: Used to treat symptoms of heartburn as Razo D exhibits anti acidic properties.
Zollinger Ellison Syndrome: Used to treat Zollinger Ellison Syndrome in which acid secretion in stomach increases. Razo D helps to counteract the increased acid secretion in such cases.
Helicobacter Pylori Infection: Used in conditions like H.pylori infections.
Erosive Esophagitis: Used to treat conditions like erosive esophagitis.
Others: Used in cases of idiopathic or diabetic induced delayed stomach emptying known as Gastroparesis.

How Does Razo D Work?

Main constituents of Razo D are Rabeprazole and Domperidone
Rabeprazole is a proton pump inhibitor (PPI ) which works by getting ionized to its active form (sulfenamide group) rapidly as soon as they are exposed to the acidic environment of the stomach
These sulfenamide group forms covalent bond with SH (Sulfhydrl) group of proton pump and blocks it irreversibly, thereby blocking the acid secretion.
Domperidone is an antiemetic, which works on the dopamine receptors as it is a dopamine antagonist. It works by impelling the food down through the food pipe from stomach to intestine at faster rate.
Domperidone also blocks the food from flowing back its way up through food pipe and inhibits vomiting centre in the brain, eventually treating the feeling of nausea and vomiting.

How to Take Razo D?

Razo D is available in form of capsules for oral administration.
The duration and dose of drug is to be followed as per the doctor and should not be altered without proper consultation.
Razo D should be taken empty stomach (at least half an hour before food), as food decreases bioavailability of Rabeprazole.
It is advised to take Razo D in the morning (before breakfast) so that its peak serum concentration coincides with maximal activity of proton pumps.
Razo D capsule should not be chewed or crushed instead it is advisable to swallow it as a whole with plenty of water.
Drug should not be discontinued without proper medical consultation even if symptoms have disappeared.

Common Dosage for Razo D

The dosage of the drug is to be decided by the doctor for every individual as per the age, weight, mental status, allergic history of the patient.
The common dose of Razo D is One capsule a day in morning before breakfast but it can be modified to two capsules a day also (in morning and evening), depending on the condition of the patient.
Razo D should not be used for more than 14 days unless advised by the doctor.
It is advisable not to alter or stop the dose of drug without proper medical consultation.

Q. What happens if I overdose on Razo D?

Razo D dosage should be strictly consumed as per the prescription by the doctor.

The doctor should be consulted immediately in case of Razo D overdose, if signs like tremors, confusion, drowsiness are seen. Overdose of Razo D can lead to toxicity

Q. What happens if I miss a dose of Razo D?

Razo D should always be taken as per the fixed time schedule and in case of missed dose, always try to consume it as soon as you remember. But, avoid taking the missed dose if it’s already time to take the second dose as it may lead to drug toxicity or drug overdose.

Q. What happens if I eat expired Razo D?

Expired Razo D may not cause any undesirable effect but it is advisable to avoid consuming expired drug as it may not be efficacious enough to provide the needed results and the doctor should be immediately consulted in case of any undesirable symptoms after consuming the expired drug.

Q. What is the onset time of Razo D?

The Drug has a half life of 1-2 hour and its effects of start within 30 minutes to 1 hour following oral administration and reaches its maximum activity (inhibition of acid) in 2 hours.

Q. Till When Does The Effect of Razo D Stay?

It takes 3-4days for normal return of acid secretion, once Razo D is withdrawn.

Also Read: Renerve Plus Dosage

When to Avoid Razo D?

Do not Consume Razo D Capsule in the following scenarios:

Liver disorders: In known cases of Liver dysfunction or diseases, Razo D should be avoided or used only when advised by the doctor.
Kidney Diseases: In known cases of Kidney disease, Razo D should be avoided unless stated otherwise by the doctor.
Allergy: In known cases of known history of allergy to Razo D or any of its ingredients.
Heart diseases: In known history of patients with Congestive heart failure.
Obstruction: In known cases of obstructive intestinal diseases.
Osteoporosis: In cases of osteoporosis, Razo D should be avoided.
Others: In cases of electrolyte disturbance especially of magnesium, potassium and calcium.

Precautions While Taking Razo D

Proper Consumption: Avoid Chewing or crushing the capsules; instead swallow the capsule as a whole.
Allergic Reaction: Allergic reaction, if occurs after taking Razo D should be immediately reported to the doctor or trained medical staff.
Prolonged use: Avoid prolonged use without medical consultation as long term use increases the risk of gastric neoplasia ( stomach cancer)
Time Interval: Fixed time interval of atleast 4-6hours between two doses if advised twice a day in severe cases.

Warnings When Taking Razo D

Consuming more than the daily prescribed dose or altering the dose in any manner may lead to increased risk of side effects.
Razo D should preferably be administered in morning.

Side-Effects of Razo D

The side effects associated with Razo D Capsule used for different treatments are:

Diarrhoea (less common)
Headache (less common)
Abdominal Pain (less common)
Dizziness (less Common)
Dry mouth (Common)
Rashes (Rare)
Dry mouth (Common)
Flatulence (less common)
Increased Chances of bone fracture (less common)
May inhibit absorption of Vitamin B12 (less common)

Are There Any Reported Allergic Reactions to Razo D?

Possible allergic reactions reported for Razo D are:

Rashes (less common)
Swelling of eye, face, lips, mouth or tongue (less common)
Loss of Consciousness (rare)

What Are The Effects of Razo D Capsule on Organs?

Dose adjustment may be required in patients with severe liver and kidney impairment
Prolonged use may lead to increased gastrin levels which further leads to increased risk of stomach cancer.

Drug Interactions With Razo D to be Careful About

It is always advisable to be careful of certain drug to drug or drug to food interactions when consuming Razo D. Always be aware of the food items, other drugs or lab tests while consuming Razo D. We explore these n details below.

1. Food Interactions with Razo D

No particular food item to be avoided.

2. Medicines Interactions with Razo D

All the potential drug interactions might not be listed here. It is always advisable that the patient must inform the physician about of all the drugs/products you use. You must notify the doctor about the herbal products that you are currently consuming. You should never alter the drug regimen without your doctor’s approval.

The common drug interactions have been noticed with the following drugs:

Alcohol (moderate)
Ketoconazole and Digoxin: decreased gastric acidity due to Razo D can decrease the absorption of Ketoconazole and Digoxin (moderate)
Warfarin, phenytoin, carbamazepin and benzodiazepines (Severe) : Razo D may enhance their effects by decreasing their metabolism.
Atropine (mild)
Clarithromycin (mild)
Amiodarone (mild)

3. Effects of Razo D on Lab Tests

Razo D doesn’t affect any laboratory test results.

4. Razo D’s interactions with Pre-existing Conditions/Diseases

Osteoporosis and Congestive heart failure are the diseases, which should be taken into consideration before consuming Razo D

Q. Can I have Razo D with alcohol?

No, as there is an increased risk of acidity and reflux in food pipe as alcohol is acidic and can also decrease the potency of the drug.

Q. Any particular food item to be avoided?

No particular food item needs to be avoided when consuming Razo D.

Q. Can I have Razo D when pregnant?

No, it is not advised as undesirable effects of Razo D are seen on foetus in animal studies. The doctor should always be notified if you are pregnant or plan to become pregnant for case specific recommendation.

Q. Can I have Razo D when feeding a baby?

Always notify the doctor if you are breastfeeding the child as a precautionary measure as Razo D is not recommended in lactating mothers.

Q. Can I drive after taking Razo D?

One should avoid taking Razo D while driving if it causes drowsiness or dizziness and it is advisable to avoid driving or operating heavy machinery in such cases.

Razo D Composition, Variant and Price – Buyer’s Guide

Razo D Variants	Razo D Composition	Razo D Price (Rs.)
Razo-D Capsule	Domperidone 30MG + Rabeprazole 20MG	Rs. 224.5 for 15 capsules.
Razo 20 MG Injection	Rabeprazole 20MG	Rs. 91

Buy & Get Minimum 20% Discount: 1mg

Substitutes of Razo D

The following are alternative drugs for Razo D:

Cyra D Capsule:
- Manufactured by – Systopic Laboratories Pvt Ltd
- Price – Rs. 43 for 10 capsules
Domzar Capsule:
- Manufactured by – Septalyst Lifesciences Pvt Ltd
- Price – Rs. 97 for 10 capsules
Bravia DSR Capsule:
- Manufactured by – Grandcure Healthcare Pvt Ltd
- Price – Rs. 111 for 10 capsules
Rabekind DSR Capsule:
- Manufactured by – Mankind Pharma
- Price – Rs. 66.54 for 10 capsules

Storage Requirements for Razo D Capsule

It should be stored at room temperature, away from direct heat and light
Drug should be kept out of children’s reach.

FAQs – 13 Important Questions Answered about Razo D

Q. What is Razo D?

Ans. Razo D is mainly a fixed dose combination of two drugs as its active ingredient namely Rabeprazole and Domperidone. Razo D belongs to the class of proton pump inhibitors as well as anti-emetics.

Anti-emetics basically treat nausea and vomiting, whereas proton pump inhibitors are used to treat acidity. It is used to treat acidity, heartburn, nausea and vomiting.

Q. What are the uses of Razo D?

Ans. It is used to treat acidity, heartburn, nausea and vomiting.

Q. What are the side effects of Razo D?

Ans. The most common side effects of Razo D are Diarrhoea, Headache, Abdominal Pain, Dizziness, Dry mouth, Rashes, Dry mouth, Flatulence, Increased Chances of bone fracture, May inhibit absorption of Vitamin B12.

Q. How effective is Razo D?

Ans. Razo D is effective as a painkiller due to its mixture of Rabeprazole and Domperidone properties. However as an Anti-emetics, there are other medicines which perform better when used to treat fever.

Q. How long does it take for Razo D to show results?

Ans. Razo D shows its effect within 30 minutes to 1 hour following oral administration and reaches its maximum activity (inhibition of acid) in 2 hours

Q. Should Razo D be taken on an empty stomach?

Ans. Razo D should be taken empty stomach for better effects.

Q. Does Razo D make you drowsy?

Ans. Razo D might cause drowsiness in few cases but it varies with every individual.

Q. What should be the time gap between the intake of 2 Razo D Capsule?

Ans. Ideal time gap of atleast 4-6 hours should be there between two doses to avoid Razo D overdose.

Q. Should I complete the whole cycle of the medicine even if cured?

Ans. Razo D should be consumed as prescribed by the doctor and in case of any severity of symptoms, immediate medical help or consultation should be taken.

And the doctor should be the one to decide when and how to stop the cycle of Razo D.

Q. Does Razo D effect my menstrual cycle?

Ans. No, it generally doesn’t affect the menstrual cycle but one should always consult the doctor in case of pre existing menstrual problems before consuming the drug

Q. Is Razo D safe for children?

Ans. Razo D should only be administered in children after proper consultation and recommendation by the Paediatrician.

Q. Are there any symptoms that I should consider before taking Razo D?

Ans. Any heart disease, osteoporosis or allergic reactions are to be taken into consideration before taking Razo D.

Q. Is Razo D legal in India?

Ans. Yes, it is legal and manufactured by Sanofi India Ltd.

Disclaimer – The information provided above is to the best of our research and knowledge. However, you are recommended to consult a physician before consuming the drug.