What is Seroquel?
Seroquel is an antipsychotic medication which contains “Quetiapine Fumarate” as its active ingredient. Seroquel is available in tablet form for oral use.
Uses of Seroquel
Seroquel is used primarily for the treatment of Schizophrenia and bipolar disorders. Seroquel is not clinically approved for treatment of dementia-related psychosis in patients as it might increase mortality in such patients.
How does Seroquel work?
Seroquel contains Quetiapine as its active ingredient. Quetiapine works by altering the level of certain chemical messengers (neurotransmitters) like dopamine in the brain.
Seroquel Price In India
|25 mg Strip of 10 Tablets||Rs 19.00|
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How to Take Seroquel?
- Seroquel medicine is available in tablet form in different strengths (25mg, 50mg, 100mg, 200mg, 300mg and 400mg)
- When taken in oral form, Seroquel can be taken with or without food. In patients with a gastric side effect, it can be taken immediately after food.
- When taken in tablet form, swallow the tablet as a whole with fluids. Do not chew, break, or crush.
- Never use Seroquel in more than the recommended dose or for longer periods of time without doctor’s consent as it may lead to a serious irreversible movement disorder.
- Do not stop treatment with Seroquel suddenly. The dosage should be tapered gradually and then stopped. Stopping the medicine suddenly may lead to withdrawal symptoms.
- In case of non-improvement of symptoms or symptoms getting worse, seek medical attention immediately.
Common Dosage & when to take Seroquel?
- The dose and duration of treatment with Seroquel depend upon the age of the patient and type/ severity of ailment and response to initial dose.
- Initial recommended dose of Seroquel in bipolar disorder – 100mg per day in two divided doses. The dose can be increased up to 400mg per day till day 4 by incrementing 100mg each day. The dose can further be increased up to 800mg per day till day 6 by incrementing no more than 200mg per day.
- Majority of patients with bipolar disorder respond between 400-800mg Seroquel per day.
- In schizophrenia patients, Seroquel should be initiated at 25mg two times a day with an increase in increment of 25-50mg two to three times a day on day 2 and day 3 to a total dose of 300-400mg by day 4 given twice or thrice daily.
- Once the desired results are achieved, the dose can then be gradually tapered by the physician and the lowest maintenance dose can be maintained till advised.
- Dose adjustment is needed in elderly and patients suffering from liver and kidney diseases.
When to avoid Seroquel?
Seroquel should not be used or should be used with caution when:
- Allergic to any of its components
- People with liver or kidney problem
- Elderly people
- Epileptic patients
- History of substance abuse
- Patients with prolonged QT intervals
- Cataract patients
- Pregnant and lactating mothers
- Patients with thyroid disorders
Side effects of Seroquel?
Seroquel may produce many side effects, although they may not be common in all the patients. Commonly observed side effects:
- Dry mouth
- Blurred vision
- Weight gain
- Difficulty in swallowing
- Increase in blood sugar levels
- Abdominal pain
- Orthostatic hypotension
- Neuroleptic malignant syndrome – high fever, excessive sweating, rigid muscles, change in the heartbeat.
- Tardive dyskinesia (rarely) – unusual uncontrolled movements of the face, lips, tongue, arms, legs etc)
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Effects on organs?
- Patients with liver and kidney disease should administer Seroquel with caution and under the observation of a doctor.
- Patients with pre-existing diabetes should use this drug with caution and under constant monitoring as Seroquel use might lead to increased blood glucose levels and thus worsen diabetes.
Reported Allergic Reactions?
Tell your doctor if you are allergic to any of its ingredients. Allergy with Seroquel may exhibit the following symptoms:
- Chest tightness
- Shortness of breath
- Swelling of the face, lips, tongue, or throat
Drug Interactions to Be Careful About?
Drug interactions refer to the effect of drugs on each other and on human body following ingestion. Large numbers of medicine have shown interaction with each other. It is advised that the patient must always inform the physician about all the medicines/over the counter products/vitamin supplements used. Consult your doctor before administering any other drugs concomitantly with Seroquel. All the possible drug interactions might not be listed here. Few important ones include:
Using all these medicines along with Seroquel can influence the therapeutic effect of these medicines and also can increase the chances of side effects.
Shows Effects / Results In?
- Patients may notice an improvement in 1-4 weeks with Seroquel therapy.
- Even if symptoms disappear, it should be taken until advised as sudden withdrawal can lead to unwanted withdrawal symptoms.
Is Seroquel Addictive?
A minimal addictive tendency has been reported with Seroquel for drug abuse.
Can I have Seroquel with alcohol?
Interaction of Seroquel with alcohol may increase the risk of side effects and may cause excessive drowsiness and calmness, therefore, it is not recommended to consume alcohol while taking Seroquel.
Any particular food item to be avoided?
No alteration in its action seen with any food product.
Can I have Seroquel when Pregnant?
- Seroquel should be used with caution in pregnancy as it has shown adverse effects on foetus when administered at doses greater than the therapeutic dose.
- Therefore Seroquel should only be used if the benefits justify the risk to the foetus.
- Always inform your doctor if you are pregnant or plan to become pregnant.
Can I have Seroquel when feeding a baby?
Seroquel should not be used in breastfeeding women as the drug may pass into breast milk and lead to fatal adverse effects in foetus.
Can I drive after taking Seroquel?
- Few patients might exhibit drowsiness, dizziness or a headache after administration of Seroquel.
- Such patients should use Seroquel with caution while driving or operating heavy machinery.
What happens if I overdose on Seroquel?
- It should not be administered in more than prescribed dose.
- Taking more medication or with increased frequency will not improve your symptoms; rather they may cause serious side-effects like dizziness, sedation, hypotension, increased heartbeat etc.
What happens if I eat expired Seroquel?
- The medicine may not work as well. Please inform your physician regarding the same.
- To be on the safer side, always check and never use an expired drug.
What happens if I miss a dose of Seroquel?
- The medicine may not work well if you miss a dose because, for effective working of the drug, a certain amount of drug must be present in your body at all times.
- Always consume the missed dose as soon as you remember. But, if it is already time for the next dose – do not double the dose.
Storage of Seroquel
Storage at room temperature away from direct heat and light.
Keep medicines away from children and pets
Pro Tips When Taking Seroquel
- Seroquel may raise your blood sugar level. Patients who are diabetics or are at increased risk of diabetes should check their blood sugar levels regularly while on Seroquel.
- Patients on Seroquel therapy may also have altered thyroid and cholesterol levels.
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