Thiopentone Sodium: Uses, Dosage, Side Effects, Price, Composition, Precautions & More

What Is Thiopentone Sodium?

Thiopentone sodium(injection form) is a barbiturate used to help patients relax before receiving general anesthesia with an inhaled medication.It has a rapid onset and is ultra short acting.

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Uses Of Thiopentone Sodium

Thiopentone sodium is used  –

  • As the sole anesthetic agent for brief (15 minute) procedures.
  • For induction of anesthesia prior to administration of other anesthetic agents.
  • To supplement regional anesthesia.
  • To provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation.
  • For the control of convulsive states during or following inhalation anesthesia, local anesthesia, or other causes.
  • In neurosurgical patients with increased intracranial pressure, if adequate ventilation is provided.
  • For narcoanalysis and narcosynthesis in psychiatric disorders.
Know more: Rutor Uses

How Does Thiopentone Sodium Work?

Thiopentone sodium is a short-acting substituted barbiturate that is more lipid soluble than other groups of barbiturates. The drug reversibly depresses the activity of all excitable tissues. The CNS is particularly sensitive and normally a general anaesthesia can be achieved with thiopental sodium without significant effects on peripheral tissues.

Also read: Betacap Price | Piriton Composition

How to Take Thiopentone Sodium?

Thiopentone sodium for injection is prepared as a sterile powder. After reconstitution with an appropriate diluent, it is administered by the intravenous route.

Common Dosage Of Thiopentone Sodium

Individual response to the drug is so varied that there can be no fixed dosage. The drug should be titrated against patient requirements as governed by age, sex and body weight.

Read more: Niclosamide Dosage

When to Avoid Thiopentone Sodium& Precautions To Take?

Care should be taken in administering the drug to patients with advanced cardiac disease, increased intracranial pressure, ophthalmoplegia plus, asthma, myasthenia gravis and endocrine insufficiency (pituitary, thyroid, adrenal, pancreas).

Read more: Cartigen Precaution | Ciplactin Precaution

Side Effects Of Thiopentone Sodium

Common side effects include –

  • Respiratory depression
  • Myocardial depression
  • Cardiac arrhythmias
  • Prolonged somnolence and recovery
  • Sneezing
  • Coughing
  • Bronchospasm
  • Laryngospasm
  • Shivering

Effect on Organs?

Respiratory depression (hypoventilation, apnea)may result from either unusual responsiveness to Thiopentone sodium or over dosage.

Myocardial depression, proportional to the amount of drug in direct contact with the heart, can occur and may cause hypotension, particularly in patients with an unhealthy myocardium.

Reported Allergic Reactions?

Symptoms of an allergic reaction to Thiopentone sodium include urticaria, bronchospasm, vasodilation and edema which should be managed by conventional means.

Drug Interactions to be careful about?

Thiopentone sodium may interact with the following drugs –

  • Probenecid
  • Diazoxide
  • Zimelidine
  • Opioid analgesics
  • Aminophylline
  • Midazolam

Shows Effects/Results In

Thiopentone sodium injection shows it’s effect instantaneously. The duration of effect varies in different individuals.

Storage Requirements for Thiopentone Sodium

Store at controlled room temperature 15° to 30°C( 59° to 86°F).

Keep reconstituted solution in a cool place.

Pro Tips When Taking Thiopentone Sodium

This drug should be administered only by persons qualified in the use of intravenous anesthetics.

Administer only clear reconstituted solutions.

Use within 24 hours after reconstitution. Discard unused portions.

Frequently Asked Questions

Is Thiopentone Sodium addictive?


Can I have Thiopentone Sodium with alcohol?


Any particular food item to be avoided?


Can I have Thiopentone Sodium when pregnant?


Can I have Thiopentone Sodium when feeding a baby?


Can I drive after taking Thiopentone Sodium?


What happens if I overdose on Thiopentone Sodium?

Not applicable. Thiopentone sodium injection is administered under medical supervision only.

What happens if I eat expired Thiopentone Sodium?

Not applicable. Thiopentone sodium infection is administered under medical supervision only.

What happens if I miss a dose of X?

Not applicable. Thiopentone sodium infection is administered under medical supervision only.

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